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#1 darksanity

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Posted 29 August 2006 - 02:05 AM


I am starting a nootropic regimen

I have :
Piracetam
Pyritinol
Idebenone
Centrophenoxine
5-HTP
L-Tyrosine
Vinpocetine
GABA
Acetyl-L Carnitine

I'm thinking about adding SAMe, Modafinil (occasionally) and Deprenyl.

What are dosages and at what times should I take it? I am about 150 lbs and 5'9 and diagnosed with ADD. I'm pretty healthy and workout 4 days/week by my brain is kind of *damaged?* because of recreational drug use...

Would it worth adding SAMe, Modafinil and Deprenyl? What's the difference between Modafinil and Adrafinil??

Is there any risk of taking too much nootropics (kidney, liver problems??)

Is there any heavy risk considering I take ADD medication (Adderall, amphetamine salts and isomers)... I don't really use it everyday (mostly because of nasty side-effects) but only when a lot of work is needed to be done...

Anything I should remove/add??

Thanks!

Edited by darksanity, 29 August 2006 - 02:26 AM.


#2 synaesthetic

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Posted 14 September 2006 - 02:43 AM

I would add R-ALA with the Carnitine to combate excess mitochondrial free radicalization

And some people are fine without it, [so see how you are on piracetam first - I've read that if you get headaches it might be because of low choline levels] but there is a nice synergetic effects from supplementing the piracetam with choline like alpha-gpc

I started off with 800mg twice daily but then after it started working I found better effects when I lowered it to about 200mg daily

Also vinpocetine also gave me a headache when I took some so I'd say be careful with your dose of that!

looks like you are off to a great stack!

[btw are you taking a good multivitamin and fishoil?]

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#3

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Posted 14 September 2006 - 03:14 PM

Actually, if you have ADD then you may benefit from SAMe. The attachment is some notes from William Walsh of the Pfeiffer Treatment Center. He says that high histamine types do better with SAMe in the beginning as opposed to using methionine. Methionine is cheaper than SAMe.

http://www.hputest.nl/lit109.doc

These notes explain what is good IF you have high histamine levels. I don't know what your histamine levels are like, but am guessing about this. I am not suggesting that you should take some diagnosis from some forum poster. You do need to research this further. His notes may seem somewhat randon; they really need to be looked at in the context of understanding the orthomolecular approach. But the notes basically some up the important nutrients needed for the different types. Research the high histamine type, for example, to see if you have any of the signs for this condition.

I have posted about using tryptophan or 5htp. You should not use either unless you have sufficient vitamin b6 and niacin levels. But if you use either one you can cause some toxicity to your brain.

This is the best explanation I know of about this toxicity.

Niacinamide-adenine dinucleotide (NAD) is an active enzyme that is required for the proper function of vital areas of the brain. In schizophrenia, there appears to be a failure to deliver enough NAD to the brain. Vitamin b3 is required for the transformation of tryptophan, an amino acid, into NAD. If there is a niacin deficiency, this necessary transformation of trypotphan into NAD is inhibited, and there is not only a NAD deficiency established, but there is also an overload of tryptophan in the brain’s chemistry. Tryptophan is considered to be one of the most toxic of amino acids. An overload of it in the brain can be very harmful, especially if it is not properly converted into NAD, because it can cause undesirable perceptual and mood changes. If there is a b3 deficiency, for whatever reason, the consequent NAD deficiency will lead to ever-increasing tryptophan overload uninterruptedly unless and until the proper levels of b3 are given.

Pyridoxine, or vitamin b6, is used in the treatment of cerebral allergies by many Orthomolecular physicians. There is clinical evidence that pyridoxine is involved in the tryptophan-niacin metabolism previously explained. Morever, b6 is a precursor to over 60 enzyme reactions, is necessary for the proper metabolism of all amino acids, and is required for the maintenance of a stable immunologic system.

Source: Brain Allergies: The Psychonutrient Connection by William H. Philpott, MD and Dwight K. Kalita, Ph.D.

I think all the different amino acids are too many. It seems like you don't know what you should focus on. You have GABA, tyrosine and 5htp. Do you really think you have that many neurotransmitter problems?

#4 systemicanomaly

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Posted 25 September 2006 - 01:10 PM

...

What's the difference between Modafinil and Adrafinil??

Is there any risk of taking too much nootropics (kidney, liver problems??) ...



Appears to be an impressive noot regimen. Best to do your homework to be sure that your ADD meds mix well with your intended nootropic program. For liver concerns try supplementing with herbs such as fenugreek and milk thistle.

In the begining (actually, the 1970s), there was Adrafinil. Modafinil is a refinement of this eugeroic stimulant. According to Wikipedia, "Modafinil is the primary metabolite of Adrafinil and has similar activity...". Modafinil has fewer & milder side effects than Adrafinil but is usually quite a bit more expensive.

(I'm sure that you can find a lot more about these 2 eueroics using the Search function above).

Adrafinl may be ok to start with, however it you are really paranoid about liver issues then you might want to spend the big bucks on Modafinil instead... or use the Adrafinil in conjunction with liver protecting herbs.

#5 ikaros

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Posted 25 September 2006 - 01:38 PM

I have :
Piracetam
Pyritinol
Idebenone
Centrophenoxine
5-HTP
L-Tyrosine
Vinpocetine
GABA
Acetyl-L Carnitine

I'm thinking about adding SAMe, Modafinil (occasionally) and Deprenyl.


Sounds like a recipe for a manic episode.

#6 salesman

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Posted 25 September 2006 - 06:22 PM

Your right that looks like your going to be messing with alot of neurotransmitter activity

#7 systemicanomaly

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Posted 26 September 2006 - 11:33 AM

I have :
Piracetam
Pyritinol
Idebenone
Centrophenoxine
5-HTP
L-Tyrosine
Vinpocetine
GABA
Acetyl-L Carnitine

I'm thinking about adding SAMe, Modafinil (occasionally) and Deprenyl.


Sounds like a recipe for a manic episode.



These guys have a point... how much of each supp were you thinking?

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#8 impulsive

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Posted 03 December 2006 - 08:03 PM

lol, couldnt help myself from laughing...

Did you actually go through with this?




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