13 replies to this topic

[manofsan]

A botanical remedy has been found to switch on IGF-1 to suppress joint inflammation and commence repair:

http://www.eurekaler...c-gtr101106.php

[maestro949]

That's great news. This is good evidence that we can find techniques for turning our repair mechanisms back on. The definition of youth is simply a fully functioning biological system including all repair mechanisms. A young person doesn't show signs of aging because of all the redundant repair mechanisms that are constantly mopping up damage. When these repair mechanism themselves get damaged by wear and tear, ut oh...

[caston]

Inflammation is a 2 sided coin then... destruction with phagocytes and free radicals followed by repair...

There does seem to be some sort of a program though as we get more "ape-like" as we get older.

Misfolded proteins may sometimes occur because of HSPs that help mediate evolution or perhaps help stop inbreeding with some some genes competing with them to actually encourage it.

The decline in stem cell lines would have a lot to do with it as well.

Getting back on-topic though... how many of the repair mechniams would be "turned off" vs "damaged"?

Why would a repair mechanism get turned off?

Edited by caston, 09 June 2008 - 04:31 AM.

[Luna]

Maybe it is never turned on?
I mean think about it.
The body has a mechanism to know how to build itself from an offspring to a person.
Once it gets to the final stage it stops building and only maintains.
What if the mechanism isn't repair but the build mechanism and since it dosen't have much work all it does is seem to be repairing?

[niner]

This study has been completed and results published. Reparagen appears to be better than Glucosamine. I wonder why we don't hear more about it? It is out there, should you want to buy it. About a buck a day. Glucosamine is way cheaper.

BMC Complement Altern Med. 2007 Oct 31;7:34. FREE FULL TEXT
Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351].Mehta K, Gala J, Bhasale S, Naik S, Modak M, Thakur H, Deo N, Miller MJ.
1Vedic Lifesciences, Pvt. Ltd., Mumbai, India. clinical@ayuherbal.com

BACKGROUND: The efficacy and safety of a dietary supplement derived from South American botanicals was compared to glucosamine sulfate in osteoarthritis subjects in a Mumbai-based multi-center, randomized, double-blind study. METHODS: Subjects (n = 95) were screened and randomized to receive glucosamine sulfate (n = 47, 1500 mg/day) or reparagen (n = 48, 1800 mg/day), a polyherbal consisting of 300 mg of vincaria (Uncaria guianensis) and 1500 mg of RNI 249 (Lepidium meyenii) administered orally, twice daily. Primary efficacy variable was response rate based on a 20% improvement in WOMAC pain scores. Additional outcomes were WOMAC scores for pain, stiffness and function, visual analog score (VAS) for pain, with assessments at 1, 2, 4, 6 and 8 weeks. Tolerability, investigator and subject global assessments and rescue medication consumption (paracetamol) were measured together with safety assessments including vital signs and laboratory based assays. RESULTS: Subject randomization was effective: age, gender and disease status distribution was similar in both groups. The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments. Using related criteria response rates to reparagen were favorable when compared to glucosamine. Compared to baseline both treatments showed significant benefits in WOMAC and VAS outcomes within one week (P < 0.05), with a similar, progressive improvement over the course of the 8 week treatment protocol (45-62% reduction in WOMAC or VAS scores). Tolerability was excellent, no serious adverse events were noted and safety parameters were unchanged. Rescue medication use was significantly lower in the reparagen group (p < 0.01) at each assessment period. Serum IGF-1 levels were unaltered by treatments. CONCLUSION: Both reparagen and glucosamine sulfate produced substantial improvements in pain, stiffness and function in subjects with osteoarthritis. Response rates were high and the safety profile was excellent, with significantly less rescue medication use with reparagen. Reparagen represents a new natural productive alternative in the management of joint health. TRIAL REGISTRATION: Current Controlled Trials ISRCTN25438351.

PMID: 17974032

[caston]

Thanks Winterbreeze,

Maybe there can be some value to supplements if the "build genes" are turned on.

If we can reverse damage to "things that are made by cells" that is an important step forward.

My joint noises still bug me... I tried ringing to see if they ship to Australia and I got the voice mail. I will try again later.

Edited by caston, 09 June 2008 - 07:21 AM.

[caston]

Check out this article. One of the ingredients is an extract from Maca for the IGF-1 and the other from cat’s claw to inhibit NF-kB!

http://www.npicenter...w...4&zoneid=27

This makes me wonder if we even need to buy the product. I have some Maca extract pills in my cupboard that I only took if I was going out for the night. It doesn't say exactly what it in the product so I don't know if it's going to have the same Maca extracts as Reparagen.


I'd really love to know more about these so called "build-genes" btw.

Edited by caston, 16 June 2008 - 02:51 AM.

[caston]

I was just wondering... could activating IGF-1 with suppressing NF-kB increase the risk of a runaway cancer?


http://en.wikipedia...._other_diseases


http://www.hno.harva...igf1.story.html

Edited by caston, 27 June 2008 - 12:08 PM.

[caston]

Just bumping an old thread. BTW my joints don't bother me at all anymore and haven't for a long time. My Dad, however, had a big problem with the cartilage in his hip and will likely need a replacement soon.

I will drill him for more details about his condition if it will help us get some helpful information for him but does anyone have experience or knowledge about using reparagen and think it may help him?

Their website is:

http://reparagen.com/

or
http://reparagen.jenxnetwork.com

Edited by caston, 11 January 2010 - 01:01 PM.

[Logan]

Just bumping an old thread. BTW my joints don't bother me at all anymore and haven't for a long time. My Dad, however, had a big problem with the cartilage in his hip and will likely need a replacement soon.

I will drill him for more details about his condition if it will help us get some helpful information for him but does anyone have experience or knowledge about using reparagen and think it may help him?

Their website is:

http://reparagen.com/

or
http://reparagen.jenxnetwork.com

What about platelet rich plasma therapy or bone marrow stem cell treatments?

I used maca combined with cat's claw for several months and didn't notice much. Maybe there is something about the reparagen formulation that makes it better, who knows.

[caston]

What about platelet rich plasma therapy or bone marrow stem cell treatments?

I used maca combined with cat's claw for several months and didn't notice much. Maybe there is something about the reparagen formulation that makes it better, who knows.

Thank you.

I looked up hip replacement stem cells on google and found the following:

New stem cell treatment 'being used by patients to avoid hip replacements'

http://www.telegraph...placements.html

I will suggest it to him.

[zorba990]

Just bumping an old thread. BTW my joints don't bother me at all anymore and haven't for a long time. My Dad, however, had a big problem with the cartilage in his hip and will likely need a replacement soon.

I will drill him for more details about his condition if it will help us get some helpful information for him but does anyone have experience or knowledge about using reparagen and think it may help him?

Their website is:

http://reparagen.com/

or
http://reparagen.jenxnetwork.com

Cissus seems to work well (lots of anecdotal reports from bodybuilding forums)

CMO pushed in with DMSO works well when I get a flareup of anything: http://www.letstalkh...otion-p/238.htm
(however it does have the DMSO stink breath effect).
You could probably make your own DMSO-CMO-MSM-Glucosamine-T_Res combo cheaper
just don't use too much DMSO and be mindful it pushes lots of things through so
do some research first!

Since it's a fat some CMO may get through the lymphatic system just with its own
topical application but probably not much.

[sentrysnipe]

Have you tried getting him some Type II Collagen?

http://www.iherb.com/Collage-Type-II
http://www.iherb.com...sules/4457?at=1

[Lufega]

Caston,

What did you do for your joint that they're not a bother anymore? Maybe for your Dad you can use both reparagen and glucosamine (maybe as NAG)? Synergy?

edit: clever, they already thought of this. Reparagen Plus jeje.. http://reparagen.com...reparagen-plus/

Edited by Lufega, 30 May 2010 - 05:01 PM.