A botanical remedy has been found to switch on IGF-1 to suppress joint inflammation and commence repair:
http://www.eurekaler...c-gtr101106.php
Posted 18 October 2006 - 09:47 PM
Posted 19 October 2006 - 07:54 AM
Posted 09 June 2008 - 04:28 AM
Edited by caston, 09 June 2008 - 04:31 AM.
Posted 09 June 2008 - 05:13 AM
Posted 09 June 2008 - 05:28 AM
BMC Complement Altern Med. 2007 Oct 31;7:34. FREE FULL TEXT
Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351].Mehta K, Gala J, Bhasale S, Naik S, Modak M, Thakur H, Deo N, Miller MJ.
1Vedic Lifesciences, Pvt. Ltd., Mumbai, India. clinical@ayuherbal.com
BACKGROUND: The efficacy and safety of a dietary supplement derived from South American botanicals was compared to glucosamine sulfate in osteoarthritis subjects in a Mumbai-based multi-center, randomized, double-blind study. METHODS: Subjects (n = 95) were screened and randomized to receive glucosamine sulfate (n = 47, 1500 mg/day) or reparagen (n = 48, 1800 mg/day), a polyherbal consisting of 300 mg of vincaria (Uncaria guianensis) and 1500 mg of RNI 249 (Lepidium meyenii) administered orally, twice daily. Primary efficacy variable was response rate based on a 20% improvement in WOMAC pain scores. Additional outcomes were WOMAC scores for pain, stiffness and function, visual analog score (VAS) for pain, with assessments at 1, 2, 4, 6 and 8 weeks. Tolerability, investigator and subject global assessments and rescue medication consumption (paracetamol) were measured together with safety assessments including vital signs and laboratory based assays. RESULTS: Subject randomization was effective: age, gender and disease status distribution was similar in both groups. The response rates (20% reduction in WOMAC pain) were substantial for both glucosamine (89%) and reparagen (94%) and supported by investigator and subject assessments. Using related criteria response rates to reparagen were favorable when compared to glucosamine. Compared to baseline both treatments showed significant benefits in WOMAC and VAS outcomes within one week (P < 0.05), with a similar, progressive improvement over the course of the 8 week treatment protocol (45-62% reduction in WOMAC or VAS scores). Tolerability was excellent, no serious adverse events were noted and safety parameters were unchanged. Rescue medication use was significantly lower in the reparagen group (p < 0.01) at each assessment period. Serum IGF-1 levels were unaltered by treatments. CONCLUSION: Both reparagen and glucosamine sulfate produced substantial improvements in pain, stiffness and function in subjects with osteoarthritis. Response rates were high and the safety profile was excellent, with significantly less rescue medication use with reparagen. Reparagen represents a new natural productive alternative in the management of joint health. TRIAL REGISTRATION: Current Controlled Trials ISRCTN25438351.
PMID: 17974032
Posted 09 June 2008 - 05:44 AM
Edited by caston, 09 June 2008 - 07:21 AM.
Posted 15 June 2008 - 02:15 PM
Edited by caston, 16 June 2008 - 02:51 AM.
Posted 26 June 2008 - 02:01 PM
Edited by caston, 27 June 2008 - 12:08 PM.
Posted 11 January 2010 - 12:59 PM
Edited by caston, 11 January 2010 - 01:01 PM.
Posted 15 January 2010 - 06:03 AM
Just bumping an old thread. BTW my joints don't bother me at all anymore and haven't for a long time. My Dad, however, had a big problem with the cartilage in his hip and will likely need a replacement soon.
I will drill him for more details about his condition if it will help us get some helpful information for him but does anyone have experience or knowledge about using reparagen and think it may help him?
Their website is:
http://reparagen.com/
or
http://reparagen.jenxnetwork.com
Posted 15 January 2010 - 07:33 AM
What about platelet rich plasma therapy or bone marrow stem cell treatments?
I used maca combined with cat's claw for several months and didn't notice much. Maybe there is something about the reparagen formulation that makes it better, who knows.
Posted 15 January 2010 - 06:40 PM
Just bumping an old thread. BTW my joints don't bother me at all anymore and haven't for a long time. My Dad, however, had a big problem with the cartilage in his hip and will likely need a replacement soon.
I will drill him for more details about his condition if it will help us get some helpful information for him but does anyone have experience or knowledge about using reparagen and think it may help him?
Their website is:
http://reparagen.com/
or
http://reparagen.jenxnetwork.com
Posted 15 January 2010 - 07:42 PM
Posted 30 May 2010 - 04:54 PM
Edited by Lufega, 30 May 2010 - 05:01 PM.
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