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Artificial livers in development


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#1 maestro949

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Posted 30 May 2006 - 01:18 PM


Blood testing and dialysis / filtration devices have made significant strides in the past decade. After meeting the goals of nephrology and disfunctional liver replacement the next steps should be for the commercial development of consumer accessible devices that could periodically cleanse a person's bloodstream of any negative agents that the liver couldn't.

Things that could be filtered are industrial toxins, carcinogens, cholesterol, harmful bacteria, prions, viruses, free floating "extra-cellular junk", etc. While screening the blood of negative compounds, periodic tests could also be done for a wide range of ailments. White blood count could even be monitored to give you a heads up even for upcoming colds and flus or indicate hidden infections. Proactive measures could be taken as well to up or down regulate hormone levels that seem inadequate, essential vitamins and mineral levels could be cirulated if needed. This mechanism could also eventually be used for more efficient drug delivery and when the technology arrives, nanobot delivery. Corrective agents (drugs) could be introduced that attack problem areas (cancers, accumulated junk, etc) on an as needed basis though this will be a bit further out.

We are nearing a point where dialysis machines are going to match that of what our kidneys and liver can do. From there it is very likely that these devices and techniques can become even more efficient. I see this area of progress as one of the more practical and realistic areas where significant gains can be made to longevity in the very near-term.

Edited by maestro949, 30 May 2006 - 08:47 PM.


#2 Live Forever

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Posted 30 May 2006 - 04:31 PM

That reminds me of this device that I saw both on the Science Channel (either the show Beyond Tomorrow, or Discoveries This Week, one of the two) and in Popular Science magazine. It is a blood filtration device that will be able to filter viruses from the bloodstream. There are two versions planned, one version that is bigger and can be stored at a hospital or somewhere else, and the portable version that is the really cool one, which is pictured here:

Posted Image

The company's web site looks like it has a little more info on it as well.

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#3 maestro949

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Posted 30 May 2006 - 08:57 PM

Good find. It would be nice to see these become commodities as fast as cell phones and laptops did.

Being linked to bioterrorism seems like a good "angle" to get investor interest. Maybe we need to recast SENS research as another way to fight terrorism and the money'll start pouring in. :)

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#4 Live Forever

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Posted 30 May 2006 - 09:25 PM

Good find.  It would be nice to see these become commodities as fast as cell phones and laptops did. 

Being linked to bioterrorism seems like a good "angle" to get investor interest.  Maybe we need to recast SENS research as another way to fight terrorism and the money'll start pouring in. :)


"Donate to SENS, so that you can outlive the terrorist bad guys!"

ummm..

"Donate to SENS, in case the terrorists use age-related disease bioterrorism."

ok, that is stretching a bit

#5 maestro949

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Posted 31 May 2006 - 01:47 AM

List of topics from the 23rd Annual Congress of the European Society for Artificial Organs

Apheresis
Artificial and Bioartificial Liver
Artificial Blood
Artificial Heart
Artificial Kidney and Dialysis
Artificial Lung and Gas Exchange
Artificial Sensory Organs
Artificial Skin
Artificial, Bioartificial Pancreas and Diabetes Treatment
Biomaterials and Surface Modifications
Biosensors
Blood pump systems
Cardiac Assist Devices
Catheter technology
Cell and Gene Therapy
Cell Transplantation
Drug Delivery Systems
Electrostimulation
Expert Systems
Fluid Dynamics
Drafts
Hybrid Artificial Organs
Image Processing
Immunoisolation
Immunomodulation
Intensive Care and Monitoring of AO- Recipients
Modeling and Simulation
Muscle Powered Assist Systems
Neuroprostheses
Organ Regeneration
Prosthesis and implants
Respiratory Systems
Robotics and Navigations
Sensory Aids
Tissue Engineering
Transplantation

Abstracts

Edited by maestro949, 07 March 2007 - 02:17 PM.


#6 eternaltraveler

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Posted 31 October 2006 - 01:33 AM

British scientists grow human liver in a laboratory

British scientists have grown the world's first artificial liver from stem cells in a breakthrough that will one day provide entire organs for transplant.


http://www.dailymail...e&icc=NEWS&ct=5

Among organs the liver is probably among the simplest (simple in that it's parenchyma is composed of only one cell type, the hepatocyte, the liver's function is extremely complex biochemically). But this is a great movement forward nontheless.

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#7 AdamSummerfield

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Posted 31 October 2006 - 07:47 AM

Ahhhhh Cool!
They could test on those and all sorts! I also read some time ago about them growing organs in labs.
Wouldnt the bladder be the simplest organ to grow? I mean, all the bladder is is a bag made of connective tissue and then nerves connected to the sphincter.

#8 JonesGuy

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Posted 31 October 2006 - 11:48 AM

I might be suffering a deficit in my google-fu ... can anyone tell where the research paper is?

#9 Lazarus Long

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Posted 31 October 2006 - 03:11 PM

I have not found the source reference yet either but here is another article from the BBC that at least details the researchers and their institute name.

Liver cells grown from cord blood

The sections of liver were created using stem cells from umbilical cords by a team at Newcastle University.

It is hoped the "mini-livers" will be used to test drugs, avoiding incidents like the Northwick Park trial in which six patients became seriously ill.

But other experts warned, because the work was unpublished, it was not possible to assess its worth and that cells made in this way were unreliable.

Researchers Dr Nico Forraz and Professor Colin McGuckin have started a company called ConoStem in an effort to market their stem cell work.


BTW they are using tech developed by NASA

The tissue is grown using a microgravity bioreactor, a piece of equipment derived from Nasa technology, which aids the creation of cells by mimicking weightlessness.


And the reason we may not find the source article is perhaps the result of loose lips.

The extent of the team's work emerged after publicity following a local business award.



#10 JonesGuy

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Posted 31 October 2006 - 03:26 PM

I can expect there to be a backlash of people claiming that ESC research is not necessary, given these results. The researchers are sure to have used ESC data, and I need to be able to prove that.

#11 Lazarus Long

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Posted 31 October 2006 - 03:33 PM

They clearly used ESC but they got them from cord blood to no doubt get around the debate on ESC. IMHO the ESC debate is moot on this point except that they won't go away as long as they can hijack the argument over embryo use.

Anyway IMHO a fascinating sidelight emerged in the article from British antivivisectionists on two scores, one the ability to produce synthetic organs for testing allowing the end of animal tests and from a more esoteric group, I saw commentary about synthetically growing meats for public consumption instead of relying on farm animals. I am sure this conversation will get very interesting as more details emerge.

#12 eternaltraveler

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Posted 06 November 2006 - 01:40 AM

http://www.nature.co...bs/nbt1257.html

Liver failure was reversed in mice using a bioartificial liver made with embryonic stem cells

#13 kent23

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Posted 06 November 2006 - 04:07 PM

Should they have done this with HSCs instead? HSCs can also
differentiate into hepatocytes, and would seem to offer at least two significant advantages over ES cells for this technique- first, they're easier to come by than ES cells, and second, we know that gene therapy is workable in HSCs in humans...

#14 Karomesis

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Posted 06 November 2006 - 10:04 PM

nice....very nice. [lol] it seems as though a week doesn't go by where there isn't at least 1 or more breakthroughs and stepping stones in our war on aging.

#15 maestro949

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Posted 23 September 2007 - 02:46 PM

Here's yet another company working on an artificial liver. They hope to get FDA approvals for trials for humans within two years.

BioEngine: One Step Closer to Artificial Liver Device

#16 Mind

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Posted 23 September 2007 - 05:41 PM

More pieces of the puzzle falling into place. Between nutritional/supplement science, bio-engineering, genomic research, and replacement organs, everything seems to be moving in the right direction for greatly extended lifespans and healthspans.

#17 Luna

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Posted 23 September 2007 - 06:40 PM

nice....very nice. [lol] it seems as though a week doesn't go by where there isn't at least 1 or more breakthroughs and stepping stones in our war on aging.


Oh yeah! gives us hope ;)

#18 Mind

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Posted 26 June 2009 - 03:39 PM

Artificial liver developed in order to speed up drug testing.

“The special feature, in our liver model for example, is a functioning system of blood vessels,” says Dr. Schanz. “This creates a natural environment for cells.” Traditional models do not have this, and the cells become inactive. “We don’t build artificial blood vessels for this, but use existing ones – from a piece of pig’s intestine.” All of the pig cells are removed, but the blood vessels are preserved. Human cells are then seeded onto this structure – hepatocytes, which, as in the body, are responsible for transforming and breaking down drugs, and endothelial cells, which act as a barrier between blood and tissue cells.

In order to simulate blood and circulation, the researchers put the model into a computer-controlled bioreactor with flexible tube pump, developed by the IGB. This enables the nutrient solution to be fed in and carried away in the same way as in veins and arteries in humans. “The cells were active for up to three weeks,” says Dr. Schanz. “This time was sufficient to analyze and evaluate the functions. A longer period of activity is possible, however.”



#19 GoodFellas

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Posted 02 August 2009 - 08:50 PM

Does anyone know when an artifical hearth will be available? Let's say you're 95 years old and you known that your hearth will stop within 1 year. If someone then inserts an artificial hearth into you won't it make you live at least 20 years more:)?

#20 Luna

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Posted 03 August 2009 - 08:57 AM

Does anyone know when an artifical hearth will be available? Let's say you're 95 years old and you known that your hearth will stop within 1 year. If someone then inserts an artificial hearth into you won't it make you live at least 20 years more:)?


What if your liver fails!
or kidnseys
or cancer!
or.. or.. or..
you get the cold and your immune system is weak!
you fall and break all your bones because of ostro..thing ^^
Or you brain stops!

being 95 years old is scary ;-; at least for now!

Edited by Luna, 03 August 2009 - 08:57 AM.


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#21 GoodFellas

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Posted 03 August 2009 - 01:51 PM

lol well anyway, I'm sure a lot of people will misuse their liver then. I.E drinking too much, pro-hormones, lots of pain killers, lots of kava, steroids etc because you known that you can just replace your liver like you're buying a new car.

Edited by GoodFellas, 03 August 2009 - 01:52 PM.





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