43 replies to this topic

[zoolander]

I am Advisor to Biogerontology and not to the Nootropics/supplement fora.

Apologies about not providing a reference

Links to psychosis

    Main article: dopamine hypothesis of psychosis

Disruption to the dopamine system has also been strongly linked to psychosis and schizophrenia.[1] Dopamine neurons in the mesolimbic pathway are particularly associated with these conditions. This is partly due to the discovery of a class of drugs called the phenothiazines (which block D2 dopamine receptors) that can reduce psychotic symptoms, and partly due to the finding that drugs such as amphetamine and cocaine (which are known to greatly increase dopamine levels) can cause psychosis. Because of this, most modern antipsychotic medication is designed to block dopamine function to varying degrees.

taken from here.

[cellfighter]

(cellfighter)


Nootropic Advisor can you cite references for your statement? I've taken deprenyl on and off for depression through my doctor and I found it very helpful for motivation. I would hate to stop taking it because you believe it could cause brain damage.

His concern is psychosis. If your doctor has prescribed it for depression and you are under a doctor's care I wouldn't base a decision to quit deprenyl on one discussion board comment.

Who in their right mind would solely base a medical concern off some guys thoughts on a forum? I wanted to review the reference he made and show it to my doctor. I would consider stopping it if his statements (or rather his knowledge of the research) showed it could have serious side effects.

(cellfighter)

I would hate to stop taking it because you believe it could cause brain damage.


A great thing to consider, is to actually work on using ones own judgement, or if one is currently not able to do that, simply work closely w/(a) skilled professional(s) to A) train such judgement and B) discuss such important health-related issues, instead of ever relying blindly on free-of-charge internet advise... But don't we know that already?

Doctors don’t always have new knowledge of every drug they prescribe and factual word of mouth information always has a place. However I doubt anyone would not fact check someone’s comments.

Apologies about not providing a reference

Zoolander your reference appears to have little to do with deprenyl, unless you are generalizing all drugs that boost or effect dopamine will cause these side effects. Which I would disagree.

[zoolander]

Sometimes you have to extrapolate things out. I'm not generally a fan of doing it but on this occasion the information I provided was one of concern/warning. As you have mentioned so politely above

Who in their right mind would solely base a medical concern off some guys thoughts on a forum?

The question then

Is it fair to assume that because deprenyl has the ability to increase synaptic dopamine levels that it also has the ability to cause psychosis? keeping in mind that the article I referenced above talks about psychosis/schizophrenia an d elevated dopamine

So......
cellfighter in the process you seem to diligently follow i.e check up on "some guys thoughts on a forum" then check up by whatever means you check up with

[cellfighter]

No disrespect intended. Any good factual information even from a guy named zoolander can be helpful. [thumb]

Edited by cellfighter, 20 November 2006 - 09:53 AM.

[zoolander]

It's good to question. Your post did come accross as a little strong but that's no problemo. I can be a little sharp/strong myself [wink]. So who am I to talk

at the end of the day (don't you just love that statement......NOT!) alls good because we have questioned and dug a little deeper [smile]

[cellfighter]

Your post did come accross as a little strong but that's no problemo.

Can i blame it on my excessively high Dopamine (just below psychosis) levels? [tung]

[zoolander]

That's what I usually do

[cellfighter]

amphetamine and cocaine (which are known to greatly increase dopamine levels) can cause psychosis

I do agree with you on this. But i think it's the massive stimulation of the areas of the brain that produce Dopamine rather than elevated levels that would damage the brain. I have not read much regarding for example L-DOPA, L-Tyrosine, Deprenyl, or Piribedil causing such damage.

One of my friends did suggest I cycle the deprenyl as follows: 3 days on deprenyl then 2 days on Piribedil. He seems to think taking a dopamine agonist with the deprenyl would reduce any chance of the deprenyl losing its effectiveness. Any thoughts?

[nootropicinfo]

In discussing what Nootropics were safe for me to use with my physician she raised a very interesting question.

"Why do you feel the need to be smarter?"

Please note, I'm not judging you especially as I have the same desire for mental improvement and my actions to attain it are not limited to Nootropics use.

Personally, I have internal paradox.  I have always been ashamed of my IQ.  Perversely I wish to increase the very difference I feel ashamed of because I feel it represents who I am.  I know I'm f-ed up but I have no problem being open about that.  You know, I can barely use the term IQ?  

How about you guys?  What motivates you to use Nootropics?

because i used to abuse massive drugs and alcohol, and caus a significant amount of damage, so im just try to be normal again.


if i was normal to begin with, i guess the correct motivatino would be to better humanity and others around you with your increased knowledge.

[nootropicinfo]

In discussing what Nootropics were safe for me to use with my physician she raised a very interesting question.

"Why do you feel the need to be smarter?"

Please note, I'm not judging you especially as I have the same desire for mental improvement and my actions to attain it are not limited to Nootropics use.

Personally, I have internal paradox.  I have always been ashamed of my IQ.  Perversely I wish to increase the very difference I feel ashamed of because I feel it represents who I am.  I know I'm f-ed up but I have no problem being open about that.  You know, I can barely use the term IQ?  

How about you guys?  What motivates you to use Nootropics?

because i used to abuse massive drugs and alcohol, and caus a significant amount of damage, so im just try to be normal again.


if i was normal to begin with, i guess the correct motivatino would be to better humanity and others around you with your increased knowledge.

I spent a few years abusing these things too. I am sitting professional exams now and feel like they might give me that edge. I'm hoping nootropics will help me retain info better therefore reducing the time I need to spend studying. Or at least bring me up to speed with the other exam sitters.

So far I seem to have spent most of my time learning about nootropics. Wish the exams were on that.

[kylyssa]

I recently had an epiphany. I desire the use of nootropics because I want to be MORE.

I love to learn. I read and read and read but there are some things I don't quite grasp. I want to be able to grasp them. I want to go onto another level of learning, the next level of understanding. I'm not seeking to better humanity I just get off on learning and want to "kick it up a notch" as Emeril would say.

OK, so "Bam!"

[garethnelsonuk]

I like to be awake and focused with decent memory recall.

[garcia2002]

I recently had an epiphany.  I desire the use of nootropics because I want to be MORE. 

I love to learn.  I read and read and read but there are some things I don't quite grasp.  I want to be able to grasp them.  I want to go onto another level of learning, the next level of understanding.  I'm not seeking to better humanity I just get off on learning and want to "kick it up a notch" as Emeril would say.

OK, so "Bam!"

ditto!

[jdog]

OK, so "Bam!"

Haha! Seconded