Ok so i was reading over at the ADHD forum and people are ranting and raving about the combination of adderall and wellbutrin for treating there add/adhd. So does anyone over here currently take both of these as an effective treatment? Would it be better than taking strattera and adderall as a combo?
Adderall & Wellbutrin
#1
Posted 18 November 2006 - 03:05 PM
Ok so i was reading over at the ADHD forum and people are ranting and raving about the combination of adderall and wellbutrin for treating there add/adhd. So does anyone over here currently take both of these as an effective treatment? Would it be better than taking strattera and adderall as a combo?
#2
Posted 18 November 2006 - 07:31 PM
[quote name='http://www.obesityresearch.org/cgi/content/full/10/7/633']Obesity Research 10:633-641 (2002)
© 2002 The North American Association for the Study of Obesity
--------------------------------------------------------------------------------
Original Research
Bupropion SR Enhances Weight Loss: A 48-Week Double-Blind, Placebo- Controlled Trial
James W. Anderson*, Frank L. Greenway, Ken Fujioka, Kishore M. Gadde, James McKenney¶ and Patrick M. O’Neil**
* Department of Internal Medicine, Veterans Affairs Medical Center, University of Kentucky, Lexington, Kentucky;
Pennington Biomedical Research Center, Baton Rouge, Louisiana;
Nutrition and Metabolic Research Center, Scripps Clinic Del Mar, San Diego, California;
Department of Psychiatry, Duke University Medical Centre, Durham, North Carolina;
¶ National Clinical Research, Inc., Virginia Commonwealth University, Richmond, Virginia; and
** Weight Management Center, Medical University of South Carolina, Charleston, South Carolina.
Address correspondence to Dr. James W. Anderson, Medical Service, 111C, Veterans Affairs Medical Center, Lexington, KY 40511. E-mail: jwandersmd@aol.com
Objective: To critically examine the efficacy of bupropion SR for weight loss.
Research Methods and Procedures: This 24-week multicenter, double-blind, placebo-controlled study randomized obese adults to placebo, bupropion SR 300, or 400 mg/d. Subjects were counseled on energy-restricted diets, meal replacements, and exercise. During a 24-week extension, placebo subjects were randomized to bupropion SR 300 or 400 mg/d in a double-blinded manner.
Results: Of 327 subjects enrolled, 227 completed 24 weeks; 192 completed 48 weeks. Percentage losses of initial body weight for subjects completing 24 weeks were 5.0%, 7.2%, and 10.1% for placebo, bupropion SR 300, and 400 mg/d, respectively. Compared with placebo, net weight losses were 2.2% (p = 0.0468) and 5.1% (p < 0.0001) for bupropion SR 300 and 400 mg/d, respectively. The percentages of subjects who lost 5% of initial body weight were 46%, 59%, and 83% (p vs. placebo < 0.0001) for placebo, bupropion SR 300, and 400 mg/d, respectively; weight losses of 10% were 20%, 33%, and 46% (p vs. placebo = 0.0008) for placebo, bupropion SR 300, and 400 mg/d, respectively. Withdrawals, changes in pulse and blood pressure did not differ significantly from placebo at 24 weeks. Subjects who completed 48 weeks maintained mean losses of initial body weight of 7.5% and 8.6% for bupropion SR 300 and 400 mg/d, respectively.
Discussion: Bupropion SR 300 and 400 mg/d were well-tolerated by obese adults and were associated with a 24-week weight loss of 7.2% and 10.1% and sustained weight losses at 48 weeks. [/quote]
[quote name='http://www.cbsnews.com/stories/2004/02/13/earlyshow/saturday/main600283.shtml']Bupropion is sold under the brand name of Wellbutrin and is an antidepressant. Like some drugs sold specifically to help lose weight, Bupropion makes users feel less hungry. A recent study found that 14 percent of those people who took the drug every day lost about 5 pounds in eight weeks. However, some people experience side effects including anxiety, constipation and nausea.[/quote]
Adderall -- on the other hand -- is a mixture of four amphetamine salts. I don't know if it would be necessary to combine these two drugs. I think the clinical effect of the amphetamines might overpower any effects of Wellbutrin to the point of little or no significance.
[quote name='http://en.wikipedia.org/wiki/Adderall']1/4 Dextro-amphetamine Saccharate
1/4 Dextro-amphetamine Sulfate
1/4 dl-amphetamine Aspartate (racemic amphetamine)
1/4 dl-amphetamine Sulfate (racemic amphetamine)[/quote]
Please report if you try it.
#3
Posted 19 November 2006 - 03:14 AM
#4
Posted 19 November 2006 - 09:30 PM
What I can tell you is that one of my friends does take Adderall and Provigil (modafinil). He says that it helps him get going in the morning because the amphetamines give him a rebound effect of being tired the next day.
#5
Posted 30 November 2006 - 12:13 AM
#6
Posted 30 November 2006 - 03:09 AM
#7
Posted 30 November 2006 - 07:48 AM
Ok so my doctor just put me on a script for Wellbutrin along with Strattera I dont think he knows what hes doing im going to need a new doctor.
I wouldn't ditch the Doc quite yet. It sounds like he is still working with you.
Wellbutrin + Strattera is at least as experimental at Strattera + Provigil -- at least according to my sources. I think you should give it a try. I took Wellbutrin for a while and it worked okay. However, I took it with Adrafinil. Hey, who knows -- Wellbutrin + Strattera + Provigil might even work for you. Of course, it might be more risky...
This is a good topic on Strattera I think for those new here. I'll reiterate that Strattera isn't great for me without Provigil. However, for me -- that's what seems to work best (my ladies -- however, might tell you a different story). [sfty]
#8
Posted 02 December 2006 - 02:41 PM
#9
Posted 02 December 2006 - 05:31 PM
#10
Posted 12 December 2006 - 03:17 PM
Salesman
#11
Posted 12 December 2006 - 07:55 PM
Good luck with those finals, Salesman!
#12
Posted 09 September 2007 - 03:33 AM
Thanks,
Salesman
#13
Posted 10 September 2007 - 11:47 AM
Thanks for digging up this post. I'm currently taking Adderall and my doc is considering the option of including Wellbutrin (guess I should update my thread soon). It doesn't sound like it's a good long term approach, however.
You mentioned you were taking immediate release for Wellbutrin. I'm assuming that was the same for the Adderall. Or are you taking Adderall XR?
#14
Posted 13 September 2007 - 12:25 AM
1) Sexual side effects (substantial loss of sexual desire)
2) Loss of energy (I feel run-down in the afternoon)
I've stopped taking effexor, and my sexual desire and energy is starting to come back. However, it is important to state that effexor was very effective in helping me deal with my social anxiety, as well as my depression. I also lost approximately 10 pounds on effexor. I have noticed that it suppresses my appetite, to at least 50% of what it was before. Now that I have stopped taking effexor, I notice my appetite is back to what it was, and I am starting to gain my weight back.
I hope that helps,
The Great RowaH
#15
Posted 13 September 2007 - 03:25 PM
According to Wikipedia. . .
". . .Both bupropion and amphetamine have noradrengic and dopaminergic activity. Possible augmentation/potentiation of effects. Bupropion has pro-convulsant properties that may be enhanced or cumulatively potentiated by amphetamine.(eg; bupropion (Wellbutrin IR, SR, XL) and (Zyban) etc.) Use only when directed."
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users