15 replies to this topic

[scottl]

Aside from LifeMirage's comments does anyone have any info/suspicious/beliefs, etc that vincamine adds anything to vinpocetine?

[zoolander]

[quote]Vinpocetine is a semi-synthetic derivative of vincamine. Vincamine is an alkaloid derived from the plant Vinca minor L., a member of the periwinkle family. Vinpocetine, as well as vincamine, are used in Europe, Japan and Mexico as pharmaceutical agents for the treatment of cerebrovascular and cognitive disorders. In the United States, vinpocetine is marketed as a dietary supplement. It is sometimes called a nootropic, meaning cognition enhancer, from the Greek noos for mind.[/quote]

quote taken from PDRhealth

Note that alot of supplement companies have vinpocetine stacked in their nuero enhancement products and suggest that you take the supplement on an empty stomach however, only a small percentage of vinpocetine is absorbed on an empty stomach as compared to with food

[quote]PHARMACOKINETICS

Vinpocetine is absorbed from the small intestine, from whence it is transported to the liver via the portal circulation. From the liver via the systemic circulation, it is distributed to various tissues in the body, including the brain. [b]Absorption of vinpocetine is significantly higher when given with food and can be up to about 60% of an ingested dose. On an empty stomach, absorption of an ingested dose can be as low as 7%.[/quote] Peak plasma levels are obtained one to one and a half hours after ingestion. Extensive metabolism to the inactive apovincaminic acid occurs in the liver. Only small amounts of unmetabolized vinpocetine are excreted in the urine, the major route of excretion of apovincaminic acid. Most of a dose is excreted within 24 hours as this metabolite. The elimination half-life of vinpocetine following ingestion is one to two hours.[/quote]

also taken from PDRhealth

[zoolander]

WTF? Your back after a break scottl and so is the quote bug?

[scottl]

I don't think that bug was ever fixed.

Thanks.

[zoolander]

lets try something....

You go away and I will try to place a quote into my comments

[cellfighter]

Oxopocetine (vinpocetine citrate) is water soluble and personally beats regular vinpocetine and vincamine.

[scottl]

Oxopocetine (vinpocetine citrate) is water soluble and personally beats regular vinpocetine and vincamine.

Isn't the brain blood barrier lipid? and if so, how does the stuff get into the CNS? Is this even commercially available?

[zoolander]

Oxopocetine (vinpocetine citrate) is water soluble and personally beats regular vinpocetine and vincamine.

beats in what way?

[cellfighter]

Isn't the brain blood barrier lipid? and if so, how does the stuff get into the CNS? Is this even commercially available?

beats in what way?

Correct scottl with rare exceptions (unique BBB transporters) normally only lipid soluble compounds (with a molecular weight < 400 Daltons) penetrate the BBB. As far as covex informed me the citrate salt acts as a carrier to get vinpocetine through the stomach into the bloodstream. Most of the citrate is released in this process and your left with fat soluble vinpocetine in higher than normal amounts. It sounds similar to water soluble vitamin e.

Covex Pharma Inc is one of the largest producers of vinpocetine, vincamine and related vinca products came out with it awhile ago.

Better in terms of it acted faster and the effects seemed stronger.

I request a sample from them and they send me 50 grams! I don't know any commercial sources for it but you can get more info below.

Info 1
Info 2
Info 3

[zoolander]

They state

A study clearly demonstrated the benefits of Oxopocetine® upon memory functions and cognitive capacity when taken with different beverages such as tea, coffee or cola drinks.

however no reference?

tut tut tut

[cellfighter]

Yeah only 1 study but hey if it work it works.

194 healthy men and women participated in a study where it was compared Vinca compounds with coffee, tea and cola beverages. The objects were students aged 19-23 and  volunteers aged 60-69. The result was obtained through the SCAG Scale and mini-mental state exam¹

Conclusions:
-The effects of the vinca compounds was shown to be significantly enhanced when administered together (synergic effect).
-Younger individuals benefited even more than the elderly ones¹

¹Clinical Study of Oxopocetine (Vinpocetine Citrate).The clinical study of Oxopocetine was performed in the Department of Clinical Immunology of the Kuban Academy of Medicine
(Krasnodar) and embraced the period between September 1996 and January 1997.

[zoolander]

agreed.

My dad is currently taking olive leaf extract for arthritic pain and told me it's working wonders. He feels better than he has ever felt before. Now who I am to tell him that there is no real scientific evidence to support his claims.

If he feels better, science or no science, then he feels better.

[xanadu]

I use vinpocetine, 20 mg a day in divided doses. I take all my vitamins and supps with food. I have noticed only a very slight nootropic effect with it but it's enough to keep me using it.

As to the quote bug, I learned a fix. What you do is put in a line break just before the [/quote] at the end. Do that and it will work fine. If you look at the failed quotes above, you see that the [/quote] is on the same line as the text. Just hit enter right before it and it will be on it's own line and it will work.

[dogbarf]

If you want a subjective opinion about vincamine, then...
Vincamine is worse than crack. It gave me palpitations and made me feel like I'd been smoking crack for days (and I hadn't, this time).
I stay away from vincamine now, but vinpocetine's effects have been mostly positive.

[mrak1979]

is vinpocetine worth using as a cognitive enhancing agent? How long does it last and is there significant effect?

[cellfighter]

If you want a subjective opinion about vincamine, then...
Vincamine is worse than crack. It gave me palpitations and made me feel like I'd been smoking crack for days (and I hadn't, this time).
I stay away from vincamine now, but vinpocetine's effects have been mostly positive.

Worse than crack? Unlikely.