Here's an article with some useful details about resveratrol research at Sitris.
http://money.cnn.com...sion=2007011912
Posted 20 January 2007 - 03:58 PM
Posted 20 January 2007 - 06:01 PM
Posted 20 January 2007 - 07:41 PM
Posted 20 January 2007 - 08:24 PM
Edited by makoss, 20 January 2007 - 09:36 PM.
Posted 21 January 2007 - 12:49 AM
Meanwhile, hoping to get an early indication of efficacy against disease, the company formulated a resveratrol-based drug, dubbed 501, to begin the tests in diabetic patients. Westphal cautions that the drug is likely to be a product for only a few indications - Sirtris's more potent medicines will probably have much broader applications. Still, in animal tests, 501's proprietary formulation gets more than ten times as much resveratrol into the bloodstream as do dietary supplements containing equal amounts of it, says the company.
Posted 21 January 2007 - 03:32 PM
Posted 21 January 2007 - 04:37 PM
Posted 21 January 2007 - 04:48 PM
Posted 21 January 2007 - 07:22 PM
Posted 21 January 2007 - 09:14 PM
501's proprietary formulation gets more than ten times as much resveratrol into the bloodstream as do dietary supplements containing equal amounts of it, says the company.
Posted 22 January 2007 - 08:28 AM
Posted 22 January 2007 - 07:45 PM
"
The activity of a STAC in vivo will depend on many factors such as its rate of uptake and metabolism. For this reason,
in vitro activity may not always correlate with the ability to activate sirtuins in cells. For example, in vivo esterases are known to readily cleave off acetyl groups from acetyl-containing molecules to release acetate (White & Hope, 1984). For this reason drugs are often acetylated in a prodrug form as a means of enhancing its properties, such as stability, without diminishing its biological activity (Takahashi et al., 1992). Derivative 5, which is acetylated at the 4’ position, was the least efficacious of the STACs in activating SIRT1 in vitro, although the lifespan extension it produced was the largest achieved by treatment with a STAC to date, possibly because it remains more stable in the yeast medium than other STACs and is cleaved by esterases once it enters the cell, releasing free resveratrol and acetate and providing a steady
stream of the active compound, but clearly more experiments will be required to confirm this.
"
edit: formating...
:-)
Posted 22 January 2007 - 08:01 PM
Posted 23 January 2007 - 02:12 AM
Posted 23 January 2007 - 07:39 PM
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