Does anyone here use piperine? Apparently it helps with the absorption of certain drugs/supplements such as CoQ-10, beta-carotene, B6, viagra (watch out - sounds painful), etc. Since it aids with the absorption of CoQ-10 would it be safe to venture that it would have the same effect on idebenone? What about ALA and ALCAR? My understanding is that piperine suppresses some of the metabolic processes in the gut/liver, etc. and allows the imbibed substance to pass into the blood with less processing from the digestive system. This would increase the amount of the substance found in the blood, but for drugs/supplements for which a metabolite was the active agent it might actually decrease the efficacy. I don't know much about chemistry/biology but I was wondering if anyone here could comment on when one could expect piperine to increase absorption and also when the use of piperine is (or is not) a good idea. Thanks in advance for any info!

piperine/bioperine
Started by
, Jan 26 2007 08:17 PM
5 replies to this topic
#1
Posted 26 January 2007 - 08:17 PM
Does anyone here use piperine? Apparently it helps with the absorption of certain drugs/supplements such as CoQ-10, beta-carotene, B6, viagra (watch out - sounds painful), etc. Since it aids with the absorption of CoQ-10 would it be safe to venture that it would have the same effect on idebenone? What about ALA and ALCAR? My understanding is that piperine suppresses some of the metabolic processes in the gut/liver, etc. and allows the imbibed substance to pass into the blood with less processing from the digestive system. This would increase the amount of the substance found in the blood, but for drugs/supplements for which a metabolite was the active agent it might actually decrease the efficacy. I don't know much about chemistry/biology but I was wondering if anyone here could comment on when one could expect piperine to increase absorption and also when the use of piperine is (or is not) a good idea. Thanks in advance for any info!
#2
Posted 29 January 2007 - 02:39 AM
Hi,
I use it with vitamins and many Rx. It's often packaged with supplements these days to increase bioavailability. I don't think it works with everything, but it works with a lot of things:
* Herbal extracts :
(e.g. CURCUMIN, BOSWELLIA SERRATA, ASHWAGANDHA, GINKGO BILOBA and CAPSAICIN)
* Water-soluble vitamins :
(e.g. Vitamin B1, Vitamin B2, Niacinamide, Vitamin B6, Vitamin B12, Folic acid and Vitamin C)
* Fat-soluble vitamins :
(e.g. Vitamin A, Vitamin D, Vitamin E, and Vitamin K)
* Antioxidants :
(e.g. Vitamin A, Vitamin C, Vitamin E, alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, pine bark bioflavonoids complex, germanium, selenium and zinc).
* Amino acids :
(e.g. lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine, and methionine)
* Minerals :
(e.g calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper and magnesium).
From
the Bioperine web site.
I use it with vitamins and many Rx. It's often packaged with supplements these days to increase bioavailability. I don't think it works with everything, but it works with a lot of things:
* Herbal extracts :
(e.g. CURCUMIN, BOSWELLIA SERRATA, ASHWAGANDHA, GINKGO BILOBA and CAPSAICIN)
* Water-soluble vitamins :
(e.g. Vitamin B1, Vitamin B2, Niacinamide, Vitamin B6, Vitamin B12, Folic acid and Vitamin C)
* Fat-soluble vitamins :
(e.g. Vitamin A, Vitamin D, Vitamin E, and Vitamin K)
* Antioxidants :
(e.g. Vitamin A, Vitamin C, Vitamin E, alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, pine bark bioflavonoids complex, germanium, selenium and zinc).
* Amino acids :
(e.g. lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine, and methionine)
* Minerals :
(e.g calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper and magnesium).
From
the Bioperine web site.
#3
Posted 01 February 2007 - 09:13 PM
Ludongbin,
I use Super Curcumin with Bioperine (piperine) from LEF. It consists of 800mg of Turmeric and ONLY 5mg of piperine. I use it once every two weeks. The reason for this is that you don't need much. The curcuminoid tends to accumulate in the brain over a lifetime and suppresses the formation of amyloid plaques. If you are going to take curcumin with piperine, take it with Vitamin E. I forgot where I read it, but curcumin has anti-cancerous and possible carcinogenic effects, and taking Vit.E may reduce the negative aspect of it. Below is a interesting article on this combination:
http://www.ncbi.nlm....st_uids=9619120
I use Super Curcumin with Bioperine (piperine) from LEF. It consists of 800mg of Turmeric and ONLY 5mg of piperine. I use it once every two weeks. The reason for this is that you don't need much. The curcuminoid tends to accumulate in the brain over a lifetime and suppresses the formation of amyloid plaques. If you are going to take curcumin with piperine, take it with Vitamin E. I forgot where I read it, but curcumin has anti-cancerous and possible carcinogenic effects, and taking Vit.E may reduce the negative aspect of it. Below is a interesting article on this combination:
http://www.ncbi.nlm....st_uids=9619120
#4
Posted 06 July 2007 - 01:30 AM
Look around the site for negative talk about Bioperine. Avoid any supplements containing it.
#5
Posted 09 July 2007 - 04:31 AM
The eternal question... do a search we have talked about it until we are blue in the face
#6
Posted 17 August 2007 - 04:21 PM
Deleted.
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