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supplements/diet in pregnancy (renamed)


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#1 doug123

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Posted 22 February 2007 - 09:14 AM


CTV.ca: News Source

Posted Image

Prenatal multivitamins lower risk of kids' cancers

Posted Image
Mother-to-be Summer MacDonald says 'I knew they were important, and this study just reinforces that.'

Updated Wed. Feb. 21 2007 10:34 PM ET

CTV.ca News Staff

Expectant mothers who take multivitamins fortified with folic acid not only guard against birth defects, but also reduce the risk of three common childhood cancers, according to new research.

"I knew they were important, and this study just reinforces that," mother-to-be Summer MacDonald told CTV News.

Researchers at Toronto's Hospital for Sick Children say multivitamins are associated with:

o a 47 per cent protective effect against neuroblastoma,
o a 39 per cent cut in rates of leukemia
o and a 27 per cent drop in rates of brain tumours.


This research was published online in the journal Clinical Pharmacology & Therapeutics.

"Here is a relatively non-expensive way to give prenatal vitamins and to prevent one of the worst outcomes in medicine for a family -- a child with cancer," Dr. Gideon Koren, a senior scientist in the SickKids Research Institute who led the study, told CTV News.

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Dr. Gideon Koren, a senior scientist in the SickKids Research Institute

Women considering pregnancy have long been advised to take folic acid to prevent congenital defects such as spina bifida. But these latest findings suggest that supplementing with a multivitamin containing folic acid may be even better.

Surveys show that fewer than half of Canadian women take prenatal multivitamins before or during pregnancy, a number doctors say needs to be increased significantly.

"Women planning pregnancies should be highly encouraged to take prenatal vitamins," said Koren.

He says taking a multivitamin is a simple step that any mother can take to help protect the health of his child before and during pregnancy.

"This affordable approach could contribute to a significant reduction in the number of childhood cancer cases diagnosed each year, which has huge implications for society at large," he said.

While other studies have looked at the effect of prenatal vitamins on rates of pediatric tumours, this is the first meta-analysis of prenatal multivitamin use before and during early pregnancy and its protective effect for several cancers.

The researchers aren't sure which components of a prenatal multivitamin offer protection against pediatric cancers but say additional research is needed.

Leukemia is the most common childhood cancer and accounts for 25 to 35 per cent of new pediatric cases each year.

Brain and spinal tumours, the second most common form of cancer, account for 17 per cent of new pediatric cancer cases each year. And neuroblastoma, the most prevalent solid tumour that occurs outside of the brain in children under the age of five, affects one in every 6,000 to 7,000 children in North America.

Dan Mornar is pleased with the finding. He watched his son Jonathan die after developing neuroblastoma and now counsels other parents dealing with a child who has cancer with the British Columbia Childhood Cancer Parents' Association.

"I'd like to be out of a job because cancer was cured or better managed. And prevention here is a key," he said.

With a report from CTV's Avis Favaro and Elizabeth St. Philip

© 2007 Posted Image All Rights Reserved.

Edited by adam_kamil, 21 May 2007 - 08:15 PM.


#2 Pablo M

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Posted 22 February 2007 - 05:59 PM

Some people do not adequately convert folic acid into the active circulating forms. It's too bad that Merck has made L-methylfolate essentially unavailable on the supplement market by upping the minimum order and refusing to sign off on the raw material's purity from microbial contamination, etc. (which is standard practice for a material supplier). The minimum order size given to Source Naturals was so large that it would have taken 12 years to get through it. Since the dose is constrained by the FDA to a ludicrous 800mcg, they had no option but to stop selling it. If I was going to have a child, I'd get a prescription for Cerefolin or MetanX, split it into fourths, and give 1/4 per day to my partner.

BTW, methyfolate is still available as an ingredient in a Metagenics product, but for some reason they like to play pretend that they're a pharmaceutical company and only dispense through practitioners.

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#3 doug123

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Posted 05 April 2007 - 02:30 AM

Published in the news today:

Reuters UK: News Source

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Vitamin pills prevent low-weight babies: study
Wed Apr 4, 2007 10:15PM BST
By Gene Emery

BOSTON (Reuters) - Extra vitamin supplements can reduce the risk of having an underweight or undersized baby, and all pregnant women in developing countries should get them, researchers said on Wednesday.

But the team, reporting in the New England Journal of Medicine, said the supplements did not lower the likelihood of premature birth or losing the fetus before birth.

The study, conducted in Dar es Salaam, Tanzania, involved 8,468 pregnant women who were free of the AIDS virus and who received iron and folic acid supplements, both proven prenatal treatments. Half were given supplements containing vitamins C, E and a mix of B vitamins. The rest got placebos.

The fetal death rate stayed around 5 percent and the rate of premature delivery was nearly 17 percent regardless of whether mothers got the vitamins, the team, led by Wafaie Fawzi of Harvard University's School of Public Health, reported.

But the risk of having a low birth-weight baby dropped from 9.4 percent among the placebo recipients to 7.8 percent for the babies whose mothers took the supplements.

"In light of these findings, we recommend that multivitamins be considered for all pregnant women in developing countries, regardless of their HIV status," Fawzi said in a statement.


His team previously found supplements saved the lives of babies of HIV-infected women.

About 20 million low birth-weight babies are born each year, 96 percent of them in developing countries. Babies of low birth weight, defined as less than 5.5 pounds (2,500 grams), are more likely to die young, have growth and learning difficulties and may later be prone to diabetes and heart disease.

"Many developing countries have a system for providing prenatal iron and folate supplements; the supplements are produced in bulk by the United Nations Children's Fund at an estimated cost of less than $1 per person for the duration of the pregnancy," the researchers wrote.

Adding the extra vitamins, they said, would probably increase that cost by just 20 cents, "and scaling up prenatal multiple micronutrient supplementation could be a highly cost-effective approach to improving both outcomes among pregnant women in developing countries."


© Reuters 2006. All rights reserved. Republication or redistribution of Reuters content, including by caching, framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

Reuters journalists are subject to the Reuters Editorial Handbook which requires fair presentation and disclosure of relevant interests.


Related topics that might be worth viewing:

1. Multivitamins can raise birthweight

2. Testing finds lead in vitamins, other problems

3. Panel neutral on multivitamins

Peace and love.

#4 doug123

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Posted 17 May 2007 - 04:48 AM

A potentially related story -- re: Pregnancy.

Source: The Daily News

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Daily asprin can cut risk of pre-eclampsia
Jenny Hope

Last updated at 22:00pm on 16th May 2007

A daily dose of aspirin during pregnancy could cut the risk of a condition developing that threatens the lives of mother and baby.

The condition, pre-eclampsia, raises blood pressure, leading to strokes and even death.

In Britain alone, it is responsible for the deaths of 600 babies and seven pregnant women each year.

But a review of 31 trials involving more than 32,000 women found that low-dose aspirin is linked to a 10 per cent reduction in the risk of developing the condition.

Women who took the drug were also 10 per cent less likely to have a very premature baby and serious pregnancy complications, says a report published in The Lancet medical journal.


Doctors say the cut in risk is "moderate" but important because around one in 12 mothers-to-be are affected by pre-eclampsia and the only treatment is to deliver the baby early with an emergency Caesarean.
In April 2000 TV presenter Melinda Messenger had to have an emergency Caesarean because of pre-eclampsia. She gave birth to a healthy baby son.

Australian and British researchers led by Dr Lisa Askie, of the University of Sydney, carried out the latest review. It is known as a meta-analysis, in which the results of previous trials are combined and re-analysed.

They found the risks of developing pre-eclampsia, of delivering before 34 weeks and of having a pregnancy with a "severe adverse outcome" all fell by 10 per cent in women taking aspirin or other antiplatelet drugs.

Aspirin did not affect the risk of the baby dying, having a small baby or bleeding events.

The effect was found in trials where low-dose 75mg aspirin (around half a tablet) was used, and higher doses up to around 150mg.

It is not clear how aspirin works but it appears to improve the defective blood clotting and blood flow which affect the placenta – the baby’s life support system – in women with pre-eclampsia.

Dr Askie’s report said: "Our data shows that antiplatelet agents produce moderate but consistent reductions in pre-eclampsia and its consequences."

Mike Rich, chief executive of the charity Action on Pre-eclampsia, said a consensus was emerging whereby women with risk factors, such as being older or obese, and having a previous or family history, should consider taking aspirin.

He said the dosage should be low – around 75-150mg, which is less than normally taken for a headache.

"Some doctors suggest taking it before pregnancy while others recommend using it during the first trimester until shortly before the baby is born," he added.

But, he warned: "Women should not self-medicate, because there may be risks, for example if they are asthmatic or have stomach problems, and they should discuss it with a doctor."


Professor Andrew Shennan from Tommy’s, the baby charity, said: "In essence, the research is reiterating what we already know about the small but important positive effect of aspirin in preventing pre-eclampsia.

"Tommy’s also believes that with obesity on the increase, which is also a risk factor for preeclampsia, further work should be carried out to assess whether aspirin has the same beneficial properties on these women."

Patrick O’Brien, spokesman for the Royal College of Obstetricians and Gynaecologists, said: "The meta-analysis shows a moderate reduction but given that preeclampsia is potentially serious for some women and their babies, this is an important finding."

Mothers reject six months of breastfeeding
http://www.dailymail...in_page_id=1774

http://www.dailymaOlder mothers at greater risk of breast cancer, warn experts il.co.uk/pages/live/articles/news/news.html?in_article_id=453535&in_page_id=1770


Take care.

#5 doug123

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Posted 21 May 2007 - 08:10 PM

News Source: Science Daily

Posted Image

Source: American Thoracic Society
Date: May 21, 2007

Eating Apples And Fish During Pregnancy May Protect Against Childhood Asthma And Allergies

Science Daily — Women who eat apples and fish during pregnancy may reduce the risk of their children developing asthma or allergic disease, suggests a new study. 

The SEATON study, conducted at the University of Aberdeen, UK, found that the children of mothers who ate the most apples were less likely to ever have wheezed or have doctor-confirmed asthma at the age of 5 years, compared to children of mothers who had the lowest apple consumption. Children of mothers who ate fish once or more a week were less likely to have had eczema than children of mothers who never ate fish.

The study did not find any protective effect against asthma or allergic diseases from many other foods, including vegetables, fruit juice, citrus or kiwi fruit, whole grain products, fat from dairy products or margarine or other low-fat spreads.


The researchers studied 1212 children born to women who had filled out food questionnaires during their pregnancy. When the children were 5 years old, the mothers filled out a questionnaire about the children's respiratory symptoms and allergies, as well as a questionnaire about their child's food consumption.

The children were also given lung function and allergy tests. Previous studies in the same children have found evidence for protective effects of vitamin E and D and zinc during pregnancy in reducing the risk of children's wheeze and asthma, notes researcher Saskia Willers, M.Sc. of Utrecht University in the Netherlands. If the new results are confirmed, she says, "recommendations on dietary modification during pregnancy may help to prevent childhood asthma and allergy."

Willers concludes that at least until age 5, a mother's diet during pregnancy might be more influential on a child's respiratory health than the child's own diet. She notes that further study of this group of children will be needed to see whether the association with the mothers' diet declines in older children, and if mothers' and their childrens' diets interact in older children.

Willers suggests that the beneficial effect of apples may come from powerful antioxidants called flavonoids, while fish's protective effect may come from omega-3 fatty acids, which other studies have suggested have a protective effect on the heart and may have a protective effect in asthma.
"Other studies have looked at individual nutrients' effect on asthma in pregnancy, but our study looked at specific foods during pregnancy and the subsequent development of childhood asthma and allergies, which is quite new," Willers says. "Foods contain mixtures of nutrients that may contribute more than the sum of their parts."

Reference: Willers SM, Devereux G, Craig LCA, et al. Maternal Food Consumption During Pregnancy and Asthma, Respiratory and Atopic Symptoms in 5-Year-Old Children. Thorax; in press. This research was presented at the American Thoracic Society 2007 International Conference, on Sunday, May 20 (Session A105; Abstract 726; Poster Board # 901).

Note: This story has been adapted from a news release issued by American Thoracic Society.


In addition, an Op/Ed story published in The New York Times today might appear to be related:

News Source: The New York Times

Posted Image

May 21, 2007
Op-Ed Contributor
Death by Veganism

By NINA PLANCK


WHEN Crown Shakur died of starvation, he was 6 weeks old and weighed 3.5 pounds. His vegan parents, who fed him mainly soy milk and apple juice, were convicted in Atlanta recently of murder, involuntary manslaughter and cruelty.

This particular calamity — at least the third such conviction of vegan parents in four years — may be largely due to ignorance. But it should prompt frank discussion about nutrition.

I was once a vegan. But well before I became pregnant, I concluded that a vegan pregnancy was irresponsible. You cannot create and nourish a robust baby merely on foods from plants.

Indigenous cuisines offer clues about what humans, naturally omnivorous, need to survive, reproduce and grow: traditional vegetarian diets, as in India, invariably include dairy and eggs for complete protein, essential fats and vitamins. There are no vegan societies for a simple reason: a vegan diet is not adequate in the long run.

Protein deficiency is one danger of a vegan diet for babies. Nutritionists used to speak of proteins as “first class” (from meat, fish, eggs and milk) and “second class” (from plants), but today this is considered denigrating to vegetarians.

The fact remains, though, that humans prefer animal proteins and fats to cereals and tubers, because they contain all the essential amino acids needed for life in the right ratio. This is not true of plant proteins, which are inferior in quantity and quality — even soy.

A vegan diet may lack vitamin B12, found only in animal foods; usable vitamins A and D, found in meat, fish, eggs and butter; and necessary minerals like calcium and zinc. When babies are deprived of all these nutrients, they will suffer from retarded growth, rickets and nerve damage.

Responsible vegan parents know that breast milk is ideal. It contains many necessary components, including cholesterol (which babies use to make nerve cells) and countless immune and growth factors. When breastfeeding isn’t possible, soy milk and fruit juice, even in seemingly sufficient quantities, are not safe substitutes for a quality infant formula.

Yet even a breast-fed baby is at risk. Studies show that vegan breast milk lacks enough docosahexaenoic acid, or DHA, the omega-3 fat found in fatty fish. It is difficult to overstate the importance of DHA, vital as it is for eye and brain development.

A vegan diet is equally dangerous for weaned babies and toddlers, who need plenty of protein and calcium. Too often, vegans turn to soy, which actually inhibits growth and reduces absorption of protein and minerals. That’s why health officials in Britain, Canada and other countries express caution about soy for babies. (Not here, though — perhaps because our farm policy is so soy-friendly.)

Historically, diet honored tradition: we ate the foods that our mothers, and their mothers, ate. Now, your neighbor or sibling may be a meat-eater or vegetarian, may ferment his foods or eat them raw. This fragmentation of the American menu reflects admirable diversity and tolerance, but food is more important than fashion. Though it’s not politically correct to say so, all diets are not created equal.

An adult who was well-nourished in utero and in infancy may choose to get by on a vegan diet, but babies are built from protein, calcium, cholesterol and fish oil. Children fed only plants will not get the precious things they need to live and grow.

Nina Planck is the author of “Real Food: What to Eat and Why.”

Copyright 2007 The New York Times Company


Also of interest may be the following topic:

Breastfed babies become smarter adults.

In the topic linked above, I posted some preliminary research (in rodents) that might suggest that choline supplementation during pregnancy could potentially make offspring "smarter." I first heard of this effect in a webcast/talk given by Nick Boström in the following webcast:

Nick Boström on cognitive enhancement, webcast presentation at the Oxford conf.
http://streaming.oii...6/16032006-1.rm (excellent presentation, btw).

Skip forward approximately 12 minutes to hear Dr. Boström discuss choline supplementation in rats and the effect of maternal diet on offspring.

*Real Player is required to view this presentation.

Take care.

P.S. I changed the topic title to "supplements/diet in pregnancy" to make it more relevant. I hope no one objects. Peace.

Edited by adam_kamil, 21 May 2007 - 08:43 PM.


#6 doug123

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Posted 29 May 2007 - 11:30 PM

News Source: The New Zealand Herald

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Plan for alcohol labels to warn pregnant women
1:55PM Tuesday May 29, 2007

Moves are under way to introduce labels on alcoholic beverages warning women of the dangers of drinking during pregnancy.

The Ministry of Health's chief adviser of public health Ashley Bloomfield said the ministry was working towards a change which would make the warnings mandatory on all alcoholic drink containers.

The ministry, with the Alcohol Advisory Council (ALAC), had made an application to the joint Australian and New Zealand food safety regulator, FSANZ.

"The Ministry of Health has (applied) to FSANZ to amend the Food Standards Code so that all containers of alcoholic beverages would be required to be labelled with a warning of the dangers of drinking during pregnancy," Dr Bloomfield said.

He said the application was still being assessed by FSANZ and a decision was expected next year.

Dr Bloomfield's comments came shortly after an announcement that health warnings were set to appear on British drinks by late 2008.

The warning labels would give the number of standard drinks inside the container, and the recommended safe drinking level for that beverage.

Zealand alcohol containers already state the number of standard drinks they carry, but there is no requirement to specify a safe level of consumption.

Dr Bloomfield said New Zealand, like Britain, suffered from a "binge drinking" culture in some parts of society.

He cited a 2004 survey of drinking habits, which found that 18 to 24 year olds drank less often than 55 to 65 year olds, but they were much more likely to consume a large amount of alcohol on a single night out.

ALAC recommended no more than six standard drinks for men, and four for women, on any one occasion.

- NZPA



#7 doug123

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Posted 23 June 2007 - 05:23 AM

Fish oil, eh?

Reuters Health: News Source

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Prenatal omega-3 may boost baby's brainpower
Fri Jun 22, 2007 12:47PM EDT
By Amy Norton

NEW YORK (Reuters Health) - Children whose mothers get enough omega-3 fatty acid during pregnancy may have sharper problem-solving skills in infancy, a small study suggests.

Researchers found that 9-month-olds whose mothers had eaten DHA-fortified bars during pregnancy performed better on a test of problem-solving abilities than infants whose mothers had not added DHA to their diets.

DHA, or docosahexaenoic acid, is one of the major omega-3 fatty acids found in oily fish like salmon, sardines and tuna. Because of the fat's vital role in brain development, experts recommend that pregnant women get 300 milligrams (mg) of DHA each day.

However, research shows that few U.S. women meet this goal.

The new findings, published in the American Journal of Clinical Nutrition, suggest that women who do get adequate DHA may aid their infants' cognitive abilities.

The study included 29 women in their 24th week of pregnancy. Half were randomly assigned to eat a cereal bar supplemented with 300 mg of DHA from fish oil, while the rest were given a bar with added corn oil to serve as a comparison. On average, the women ate five bars per week.

Their babies underwent standard tests of infant problem-solving and memory at the age of 9 months. The problem-solving task tested the infants' ability to retrieve a toy that was covered by a cloth.

In general, the researchers found, babies in the DHA group performed better on the test than those in the comparison group. There was no difference between the two groups on the memory test.


It's not entirely clear what the better problem-solving performance at 9 months of age will mean later in life. However, other studies have found that DHA supplements during pregnancy seem to offer a "developmental advantage" later in childhood as well, Dr. Carol J. Lammi-Keefe, a co-author on the current study, told Reuters Health.

One study found that giving women fish oil during pregnancy and during the first few months of breastfeeding seemed to boost their children's IQ scores at age 4.

"DHA during pregnancy has benefits for infant neural development, and most pregnant women can benefit from increasing the intake of DHA in their diets," said Lammi-Keefe, of Louisiana State University in Baton Rouge.

Women can go a "long way" toward getting 300 mg of DHA per day by eating a couple tuna fish sandwiches, plus a serving of fatty fish like salmon, each week, according to Lammi-Keefe.

Other sources of DHA, she noted, include fish oil pills and algae-derived DHA, which is included in some prenatal vitamins.

Pregnant and breastfeeding women should avoid certain fatty fish, however, because they could have high mercury levels. These include shark, swordfish, king mackerel and tile fish.

SOURCE: American Journal of Clinical Nutrition, June 2007.

© Reuters 2006. All rights reserved. Republication or redistribution of Reuters content, including by caching, framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

Reuters journalists are subject to the Reuters Editorial Handbook which requires fair presentation and disclosure of relevant interests.



#8 doug123

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Posted 12 July 2007 - 07:03 AM

First, some introductory information regarding the primary source of evidence, The New England Journal of Medicine; information from Wikipedia -- that seems to be accurate as of July 11, 2007:

New England Journal of Medicine
From Wikipedia, the free encyclopedia

The New England Journal of Medicine (New Engl J Med or NEJM) is a peer-reviewed medical journal published by the Massachusetts Medical Society. It is one of the most popular and widely-read peer-reviewed general medical journals in the world. It is also the oldest continuously published medical journal in the world.

It was founded by Dr. John Collins Warren in 1812 as a quarterly called The New England Journal of Medicine and Surgery. In 1828, it became a weekly, and was renamed The Boston Medical and Surgical Journal; one hundred years later, it took on its present name.

It publishes editorials, papers on original research, widely-cited review articles, correspondences, case reports, and has a special section called "Images in Clinical Medicine".

Authors have included Oliver Wendell Holmes, Sr., Hans Zinsser, and Lewis Thomas. One of its early editors, Jerome V. C. Smith, resigned in 1857 to assume his duties as mayor of the City of Boston.

The website for the George Polk Awards noted that its 1977 award to the New England Journal of Medicine "provided the first significant mainstream visibility for a publication that would achieve enormous attention and prestige in the ensuing decades"[1]

The journal usually has the highest impact factor of the journals of clinical medicine (including the Journal of the American Medical Association, and The Lancet); in 2006, the impact factor was 51, according to Journal Citation Reports, the first research journal to break 50.

1.  ^ http://www.brooklyn....lk/history.html


Here is the study abstract:

Posted Image
Volume 357:135-142  July 12, 2007  Number 2

Reduction in Neural-Tube Defects after Folic Acid Fortification in Canada

Philippe De Wals, Ph.D., Fassiatou Tairou, M.Sc., Margot I. Van Allen, M.D., Soo-Hong Uh, M.Sc., R. Brian Lowry, M.D., Barbara Sibbald, M.Sc., Jane A. Evans, Ph.D., Michiel C. Van den Hof, M.D., Pamela Zimmer, M.H.S.A., Marian Crowley, M.N., Bridget Fernandez, M.D., Nora S. Lee, M.Sc., and Theophile Niyonsenga, Ph.D.

ABSTRACT

Background In 1998, folic acid fortification of a large variety of cereal products became mandatory in Canada, a country where the prevalence of neural-tube defects was historically higher in the eastern provinces than in the western provinces. We assessed changes in the prevalence of neural-tube defects in Canada before and after food fortification with folic acid was implemented.

Methods The study population included live births, stillbirths, and terminations of pregnancies because of fetal anomalies among women residing in seven Canadian provinces from 1993 to 2002. On the basis of published results of testing of red-cell folate levels, the study period was divided into prefortification, partial-fortification, and full-fortification periods. We evaluated the relationship between baseline rates of neural-tube defects in each province and the magnitude of the decrease after fortification was implemented.

Results A total of 2446 subjects with neural-tube defects were recorded among 1.9 million births. The prevalence of neural-tube defects decreased from 1.58 per 1000 births before fortification to 0.86 per 1000 births during the full-fortification period, a 46% reduction (95% confidence interval, 40 to 51). The magnitude of the decrease was proportional to the prefortification baseline rate in each province, and geographical differences almost disappeared after fortification began. The observed reduction in rate was greater for spina bifida (a decrease of 53%) than for anencephaly and encephalocele (decreases of 38% and 31%, respectively).

Conclusions
Food fortification with folic acid was associated with a significant reduction in the rate of neural-tube defects in Canada. The decrease was greatest in areas in which the baseline rate was high.

Source Information

From Laval University, Quebec, QC (P.D.W., F.T.); the University of British Columbia, Vancouver (M.I.V.A.); British Columbia Ministry of Health, Victoria (S.-H.U.); Alberta Health and Wellness, Calgary (R.B.L., B.S.); the University of Manitoba, Winnipeg (J.A.E.); Dalhousie University, Halifax, NS (M.C.V.H.); the IWK Health Centre, Halifax, NS (P.Z.); Health Science Centre, St. John's, NL (M.C., B.F.); Food Directorate, Health Canada, Ottawa (N.S.L.) — all in Canada; and Robert Stempel School of Public Health, Florida International University, Miami (T.N.).

Address reprint requests to Dr. De Wals at the Département de Médecine Sociale et Préventive, Université Laval, Pavillon de l'Est, Local 1110, 2180, Chemin Sainte-Foy, Quebec, QC G1K 7P4, Canada, or at philippe.dewals@msp.ulaval.ca.


Here's a mainstream report on this matter, click here -- that's Health Day News' report called: "Folic Acid Fortification a Success in Canada."

Wow, so go folic acid in Neural-Tube Defects! [thumb] In Canada. I think it's probably safe to say we'd be likely to find a reduction in Neural-Tube Defects due to folic acid fortified foods countries outside of Canada?

Thoughts, comments?

Take care.

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#9 doug123

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Posted 08 September 2007 - 10:47 PM

Some media sources just reported on a study that was published online originally May 29, 2007 -- I'm just catching up now -- the study was originally reported in The Journal of Clinical Endocrinology & Metabolism; some information regarding this publication:

The Journal of Clinical Endocrinology & Metabolism is the world's leading peer reviewed journal of clinical practice and applied clinical research. Each issue provides fast and in depth coverage of diabetes, reproductive endocrinology, growth hormone therapy, thyroid disease, and other critical areas of clinical endocrinology. Regular features highlight current topics in clinical medicine, such as clinical studies, clinical case seminars, management of endocrine disorders, practice management issues, original patent oriented research studies, and other significant new endocrine studies related to human physiology and disease. According to the latest ISI Journal Citation Report, JCE&M articles were cited almost 38,000 times in 2000. It has the highest Impact Factor ranking (#9) of any clinical journal in the ISI category of endocrinology and metabolism.


So here's the abstract:

Posted Image

Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-0718
The Journal of Clinical Endocrinology & Metabolism Vol. 92, No. 9 3517-3522
Copyright © 2007 by The Endocrine Society

Maternal Vitamin D Deficiency Increases the Risk of Preeclampsia

Lisa M. Bodnar, Janet M. Catov, Hyagriv N. Simhan, Michael F. Holick, Robert W. Powers and James M. Roberts
Department of Epidemiology (L.M.B., J.M.C., J.M.R.), University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261; Department of Obstetrics, Gynecology, and Reproductive Sciences (L.M.B., J.M.C., H.N.S., R.W.P., J.M.R.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261; Magee-Womens Research Institute (L.M.B., J.M.C., H.N.S., R.W.P., J.M.R.), Pittsburgh, Pennsylvania 15213; and Vitamin D Laboratory (M.F.H.), Section of Endocrinology, Nutrition and Diabetes, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02115


Address all correspondence and requests for reprints to: Lisa M. Bodnar, Ph.D., M.P.H., R.D., Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, A742 Crabtree Hall, 130 DeSoto Street, Pittsburgh, Pennsylvania, 15261. E-mail: bodnar@edc.pitt.edu.

Context: Vitamin D has direct influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet the vitamin D-preeclampsia relation has not been studied.

Objectives: We aimed to assess the effect of maternal 25-hydroxyvitamin D [25(OH)D] concentration on the risk of preeclampsia and to assess the vitamin D status of newborns of preeclamptic mothers.

Design and Setting: We conducted a nested case-control study of pregnant women followed from less than 16 wk gestation to delivery (1997–2001) at prenatal clinics and private practices.

Patients: Patients included nulliparous pregnant women with singleton pregnancies who developed preeclampsia (n = 55) or did not develop preeclampsia (n = 219). Women’s banked sera were newly measured for 25(OH)D.

Main Outcome Measure: The main outcome measure was preeclampsia (new-onset gestational hypertension and proteinuria for the first time after 20 wk gestation). Our hypotheses were formulated before data collection.

Results: Adjusted serum 25(OH)D concentrations in early pregnancy were lower in women who subsequently developed preeclampsia compared with controls [geometric mean, 45.4 nmol/liter, and 95% confidence interval (CI), 38.6–53.4 nmol/liter, vs. 53.1 and 47.1–59.9 nmol/liter; P < 0.01]. There was a monotonic dose-response relation between serum 25(OH)D concentrations at less than 22 wk and risk of preeclampsia. After confounder adjustment, a 50-nmol/liter decline in 25(OH)D concentration doubled the risk of preeclampsia (adjusted odds ratio, 2.4; 95% CI, 1.1–5.4). Newborns of preeclamptic mothers were twice as likely as control newborns to have 25(OH)D less than 37.5 nmol/liter (adjusted odds ratio, 2.2; 95% CI, 1.2–4.1).

Conclusions: Maternal vitamin D deficiency may be an independent risk factor for preeclampsia. Vitamin D supplementation in early pregnancy should be explored for preventing preeclampsia and promoting neonatal well-being.


So it seems vitamin D may prevent preeclampsia. Another recent topic on Vitamin D is Vitamin D deficiency and overdose in NEJM

For a mainstream version on this story, you may click here to read: "Lack of vitamin D linked to pre-eclampsia."

It seems there may be several things a mother can do to improve her chances of having a healthy pregnancy -- and perhaps even a healthier child.

There is also recent evidence that might suggest smoking tobacco or marijuana may damage sperm click here to read: "Smoking May Harm Sperm, Male Fertility" and here to read: "Marijuana smoking damages sperm."

Take care.




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