Any opinions on centrophenoxine?
26 Feb 2007
magrus
01 Mar 2007
01 Mar 2007
magrus
02 Mar 2007
Best of luck.
Centurion
02 Mar 2007
02 Mar 2007
What's the typical dosage you take? Do you cycle? Do you take it along with any other nootropics?
nancy_axel
12 Nov 2008
What are people's opinions here on centrophenoxine as a nootropic? Any positive or negative experiences? I am not currently taking any nootropics but I'm considering adding centro and/or piracetam to my supplement regime. Any opinions or suggestions? I am fairly sharp as it is, but I need some extra reserves of mental energy since I have some major intellectual mountains to scale over the next year or so. I am looking for something that is relatively safe and doesn't get me (too) wired. Thanks in advance for your thoughts.
I found centro to be an incredibly potent memory enhancer. The problem that I've noticed is that if I eat or drink after having the centro, I notice the centro wearing away. I am also susceptible to mental fog sometimes.
My stack includes 100 mg huperzine, centro and deprenyl.
nancy_axel
10 Jan 2009
Mr.Bananas
10 Jan 2009
They arent identicalCentro vs DMAE .. Why is it that DMAE is touted to combat anxiety and depression while Centro (which has DMAE as a major component) has a warning that it may cause Depression and Anxiety? As far as I'm concerned .. these 2 are identical molecules although centro can traverse the blood brain barrier and has a few more potent effects .. couldn't you just scale back the centro?
centro:
DMAE:
So a different effect is expected.
Pike
18 Jan 2009
Long-term administration of centrophenoxine and cleregil was found to exert on rats the antiamnestic and anxiogenic-like effects, to increase emotional reactivity and aggressiveness, to reduce motor activity and readiness to contact. The withdrawal of centrophenoxine and especially cleregil was followed by still greater enhancement of emotional reactivity and the appearance of spontaneous aggressiveness
http://www.biomedexp...d_long-term_use
conradshark
01 Apr 2012
Dosage
Elderly people with significant intellectual decline/ may need three to six 250mg tablets per day taken preferably with breakfast and lunch, in order to avoid insomnia. Healthy younger people may need only one or two 250mg tablets daily with breakfast or lunch. To avoid any slight acetylcholine excess occurring, it is wise take occasional breaks from dosage (say, one day a week).
ta5
01 Apr 2012
New insights on Dimethylaminoethanol (DMAE) features as a free radical scavenger.
Malanga G, Aguiar MB, Martinez HD, Puntarulo S.
Source
Fisicoquímica, Facultad de Farmacia y Bioquímica, Junín 956, 1113 Buenos Aires, Argentina. susanap@ffyb.uba.ar.
Abstract
Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.
PMID: 22300295
Baten
01 Apr 2012
Junk Master
02 Apr 2012
Baten
02 Apr 2012
I vastly prefer it to any choline source I've tried, and to DMAE. What's the most anyone here has taken? A tablespoon?
When mixing lots of racetams I take 1g of centro.
solarfingers
24 Jun 2013
jly1986
24 Jun 2013
As for the positives, yes, centro does give me a noticeable boost in sensory experience, and it goes well with Noopept.
jly1986
24 Jun 2013
solarfingers
24 Jun 2013
By the way, if anyone else has had similar experiences with centro or B causing depression and figured out an effective remedy against the supplement-induced depression, please share what helped. Thanks.
I must be on the upside of Centro because I am in an annoyingly great mood. Annoying to everyone else I mean! If you are experiencing depression it could be that you are loosing dopamine somehow. You could try L-Phenylalanine and L-Tyrosine as they help you maintain a healthy level of dopamine. Also, SAMe has great benefits of which one is an elevated mood.
Edited by solarfingers, 24 June 2013 - 09:43 PM.
jly1986
24 Jun 2013
By the way, if anyone else has had similar experiences with centro or B causing depression and figured out an effective remedy against the supplement-induced depression, please share what helped. Thanks.
I must be on the upside of Centro because I am in an annoyingly great mood. Annoying to everyone else I mean! If you are experiencing depression it could be that you are loosing dopamine somehow. You could try L-Phenylalanine and L-Tyrosine as they help you maintain a healthy level of dopamine. Also, SAMe has great benefits of which one is an elevated mood.
Thanks for the suggestions. Yeah, it's a real bummer when I can't experience the full benefits of a powerful noot like centro due to rate-limiting depression. I will try your suggestions and see if they help. Thanks again!
Dissolvedissolve
24 Jun 2013
I take 500mg of Centro with ALCAR and Piracetam and my brain has moved from 5 miles to 50 miles per hour. I have a hard time sleeping because I'm thinking so much.
I must be on the upside of Centro because I am in an annoyingly great mood. Annoying to everyone else I mean!
Not to be too alarmist, as you might be totally fine, but pressured thoughts, difficulty sleeping, and elevated mood are signs of hypomania. You might want to lower your dosage slightly - racetams can occasionally precipitate hypomania.
Edited by Dissolvedissolve, 24 June 2013 - 10:18 PM.
solarfingers
24 Jun 2013
solarfingers
24 Jun 2013
Well my good mood is either because of physiological changes due to the Centro or it has more to do with my overall outlook right now. I'm not sure. I am naturally a creative person so it would be hard to tell otherwise. I have about the same swing of moods as most people however so I don't think I'm bipolar... at least not yet. I've only been on Centro for three days. Lets give it a wait and see.
jly1986
24 Jun 2013
By the way, if anyone else has had similar experiences with centro or B causing depression and figured out an effective remedy against the supplement-induced depression, please share what helped. Thanks.
I must be on the upside of Centro because I am in an annoyingly great mood. Annoying to everyone else I mean! If you are experiencing depression it could be that you are loosing dopamine somehow. You could try L-Phenylalanine and L-Tyrosine as they help you maintain a healthy level of dopamine. Also, SAMe has great benefits of which one is an elevated mood.
I forgot to ask ... should I take both L-Phenylalanine and L-Tyrosine together, or one or the other?
Thanks!
Also, any recommendations regarding dosage of L-Phenylalanine and/or L-Tyrosine?
solarfingers
24 Jun 2013
dav345
13 Mar 2017
I take them together 500 mg each in the morning. I can say that I have a very level mood on them... You should read up on them and make your own decision to take them. Never just take anyone's word for it... Unless it's your Mum.
I recommend around 500 mg of phenylethylamine. It HAS to be taken with an MAOI inhibitor to work. Hordenine is a crude sacrificial MAOI, taken at 30 mg dosages 30 minutes before taking the phenylethylamine dose. Selgiline at 5-10 mg per day is best, if you can get it (not hard). Tyrosine isn't necessary if you are taking phenylethylamine and an MAOI inhibitor. Phenylethylamine will stimulate you and make you feel good because it acts like a stimulant by boosting dopamine. It only lasts around 1.5-2 hours before you have to re-dose, though. It works best on an empty stomach, and remember to stay very well hydrated if you want to continue feeling good (dopamine is dehydrating).
