9 replies to this topic

[lhobbs1]

I found this site today while googling for information on l-carnosine. Normally I would just lurk but found some interesting comments on melatonin and wanted to post. So here I am. So far, I have found this to be a fantastic resource.
I will be looking for ways to regenerate the cells that create the heartbeat. After jogging for years I tapered off and my heartrate decreased instead of increasing and became arrhythmic (afib), so I now find myself with a pacemaker. I would like to be able to have it removed some day. Any advice would be appreciated.

[imipolex]

This could be irrelevant, since it sounds like you have a more serious diagnosis than the ones I am familiar with (basic arrythmias), but it's worth mentioning anyway. Two items:

Magnesium: Not sure about the research on this and arrythmias, but I have seen daily (quality) magnesium vs. not have a direct impact on arrythmias. (You take Mg, they're gone; you forget for a few days, they're back.)

Food allergies/reactions: Likewise, I have personally experienced arrythmias directly attributable to food (in this case, excessive gluten).

Again, might not apply in your case, but it's good to be aware of these potential culprits.

[Karomesis]

I'm not too familiar with afib arrythmia but from what I understand some of the statins are thought to bring about stem cell changes in the heart.

http://www.ncbi.nlm....2&dopt=Abstract

http://eurheartj.oxf...full/26/16/1685

[lhobbs1]

The "experts" told me Mg would not help but I tried it anyway and they were right. As to statins I had not taken any until after pacemaker implant when I was found to be type 2 diabetic. Took Lipitor for a couple of weeks then stopped due to potential liver effects and now take 500mg T-R niacin instead. Just ordered l-carnosine, acetyl l-carnitine and multi vitamin to add to my supplements list.

[niner]

lhobbs1, have you found anything that says that l-carnosine might regenerate the cells that create heartbeat? My understanding of carnosine's mechanism of action is that it is an inhibitor of protein glycation. It is also thought to increase protein turnover, which is a way to get rid of existing glycation endproducts. This makes sense in that carnosine has been shown to improve conditions that are the result of protein modification, such as cataracts. If all carnosine did was prevent glycation, it should be able to keep things from getting worse, but not make them better. Wherever your cardiac defect lies, pacemaker cells, myocytes, or something else, if the problem is due to proteins that have been oxidized, glycated, etc, then it's at least conceivable that carnosine could be helpful. If the problem is insufficient cells, then I don't see carnosine doing much.

[narcissistic]

have you trid large doses of taurin?

[lhobbs1]

Niner, thanks for your comments. I have not started l-carnosine yet, it's on order. I ordered it on the advise of Dr. Al Sears after reading"The Doctor's Heart Cure" and more to prevent further cardiovascular problems than to address the sino- atrial node problem specifically. Also I was recently diagnosed with type 2 diabetes and Sears says that this is a glycation problem, as well as aging, arthritis, cancer and Alzheimer's, which my parents individually had problems with.
Narcissistic, in response to your question, I took taurine for a time but perhaps not enough (500 mg/day I think) and not for long enough. It may be time to revisit that.

[niner]

Lhobbs1, if you have diabetes, then the l-carnosine should be a winner. I would also consider AOR AGE Amadori for a really complete anti-glycation package. AGE Amadori is pretty reasonably priced for what it is, considering that it is an AOR product especially. AGE Amadori has (among other things) pyridoxamine, which used to be hard to get.

[Karomesis]

Also I was recently diagnosed with type 2 diabetes and Sears says that this is a glycation problem, as well as aging, arthritis, cancer and Alzheimer's, which my parents individually had problems with.

have you had a chance to review some of the studies on pyridoxamine and benfotiamine? 2 extremely potent inhibitors of AGE's.

[narcissistic]

Narcissistic, in response to your question, I took taurine for a time but perhaps not enough (500 mg/day I think) and not for long enough. It may be time to revisit that.

tarine seams to be the number one supplement arrhythmia best combined with argnine and magnesium. if you are considering taurin its necessary to take several of grams and preferably spread it on several doses during the day, 500 milligram is abbot the daily dos you can maintain from eating a lot of shellfish. a friend of mine has told me that large doses of taurin is used in Japan to treat this kind of disorder.

I fond this page:

http://www.george-eb...ml/taurine.html

maybe you will have to do more research but it might give a general idée.

Edited by narcissistic, 13 March 2007 - 03:28 PM.