54 replies to this topic

[wootwoot]

I am looking for supplements that will minimize the damaging effects of alcohol. I know that the best way to prevent these is moderation which I try to exercise as much as possible but I am looking for something that will protect me from acetaldehyde. Any supplement that can help minimize damage that I can take either while drinking or afterwards would be very helpful. Thank you.

[health_nutty]

Look into resveratrol. I remember reading something here but am too busy to do a search.

[luv2increase]

N-acetyl-cysteine used "BEFORE" drinking would be great along with some b-vitamins. Don't use nac while drinking or after!

[niner]

Some pharma guys that I used to hang out with swore by tagamet (cimetidine, an h2 antag) as a hangover preventive. The last time I overdrank, I took an OTC H2 antagonist (ranitidine/zantac) afterward, which may not have been as good as taking it beforehand, but the next day I didn't feel that bad, considering. This may not help with respect to acetaldehyde, but it might make you feel better, and is dirt cheap as a generic.

[luv2increase]

The thing I always did to prevent hangovers was drink lots of water before, during, and after my drinking endeavors. Worked like a charm. I've never used the nac thing but know it helps offset the oxidative damage done by alcohol, from what I've read.

[Shepard]

NAC/Lipoic acid
Taurine/Creatine
Lecithin/PPC
B-Complex
Basic antioxidant mix if you want: GTE, Vitamin C, etc.

[VP.]

Here is the study on resveratrol and alcohol. Works great if you're a rat. Compelling results if you ask me, but I recommend resveratrol without the extra alcohol.

Resveratrol reduces the mortality and liver damage associated with alcohol abuse.

Effect of resveratrol on alcohol induced mortality and liver lesions in mice. ABSTRACT OBJECTIVE: Resveratrol is a poly- phenol with important anti inflammatory and antioxidant properties. We investigated the effect of resveratrol on alcohol induced mortality and liver lesions in mice. DESIGN: Mice were randomly distributed into four groups (control, resveratrol-treated control, alcohol and resveratrol-treated alcohol). METHODS: Chronic alcohol intoxication was induced by progressively administering alcohol in drinking water up to 40% v/v. The mice administered resveratrol received 10 mg/l in drinking water. The animals had free access to standard diet. Blood levels were determined for transaminases and IL-1. A histological evaluation was made of liver damage, and survival among the animals was recorded. RESULTS: Transaminase concentration (liver enzyme) was significantly higher in the alcohol group than in the rest of groups (p<0.05). IL-1 levels were significantly reduced in the alcohol plus resveratrol group compared with the alcohol group (p<0.05).

Histologically, the liver lesions were more severe in the alcohol group, though no significant differences between groups were observed. Mortality in the alcohol group was 78% in the seventh week, versus 22% in the alcohol plus resveratrol group (p<0.001). All mice in the alcohol group died before the ninth week.  At the 8th week 100% of alcohol-treated mice had died versus 50% of alcohol+ resveratrol-treated animals.
CONCLUSIONS: Resveratrol reduces the mortality and liver damage associated with alcohol abuse. Bujanda L, Garcia-Barcina M, Gutierrez-de Juan V, Vidaurazaga J,
Fernandez de Luco M, Gutierrez-Stampa M, Larzabal M,
Hijona E, Sarasqueta C, Echenique-Elizondo M,
Arenas JI.

http://www.biomedcen.../6/35/abstract/

[capsule_guy]

For sure 1000mgs of NAC along with some Vit C plus b6 before you drink. I have made some on the site before and they work wonders.



The ethanol(alcohol is processed and broke down in the liver. What results are damaging free radicals being created. These are quickly 'mopped' up by the enzyme glutathione. Stores are tapped rather quickly and whats left of the toxins are able to cause havic to the body.


"Several studies have been performed to confirm that NAC is converted to glutathione in the body. A review of these studies showed that oral NAC supplementation was successful in enhancing the levels of glutathione in the liver."

With greater stores of glutathione to rely on less damage is caused when alcohol break down occurs

Customcapsule.com

Edited by customcapsule, 28 March 2007 - 05:32 AM.

[jdog]

There's some stuff that LEF makes which is probably exactly what you're looking for.

[markymark]

To me the traurine data were always very interesting.
Medline is full of positive studies (in rats) under ethanol challenge...

PMID: 10787401

PMID: 10456581

[ageless]

For sure 1000mgs of NAC along with some Vit C plus b6 before you drink.  I have made some on the site before and they work wonders. 



The ethanol(alcohol is processed and broke down in the liver.  What results are damaging free radicals being created.  These are quickly 'mopped' up by the enzyme glutathione.  Stores are tapped rather quickly and whats left of the toxins are able to cause havic to the body. 


"Several studies have been performed to confirm that NAC is converted to glutathione in the body. A review of these studies showed that oral NAC supplementation was successful in enhancing the levels of glutathione in the liver."

With greater stores of glutathione to rely on less damage is caused when alcohol break down occurs

Customcapsule.com

I haven't seen any commercial anti-hangover products that actually have effective ingredients... ie. what i believe effective based on science would include Milk Thistle, NAC, R-LA, B's, C, taurine, curcumin and some other flavanoids. I know it works first-hand.
Main thing to remember is ethanol depletes glutathione stores in the liver as the liver uses this endogenous antiox to detoxify... it's the reason why drinking plus liver toxic drugs like acetaminophen wreak total havoc and sometimes kill liver cells. Many people have had liver failure from a night of drinking and subsequent acetaminophen popping to recover. The bodies liver glutathione stores become overloaded.
Whey protein may not be the most convernient tool but its' high cysteine content helps raise glutathione as well. A nice hangover cocktail that includes a whey shake would be a great idea also.

I have recently decided to try custom capsule and think that would be an awesome way to design your own cocktail that science prove works.
Split the doses before and after and it should not only save you from the headaches and other hangover symptoms, but should also save your body and mind from a fun nights out.

[Shepard]

I'm still leary about some supplementation post-drinking. Ethanol metabolism is weird enough that I prefer to keep to water/sleep instead of a multitude of anti-hangover supplements.

[ageless]

I might add that methyl donors are important to liver function and detoxification.
These include folic acid, B6, B12 and Trimethylglycine.
Another ingredient theanine with a link to lef on theanine and alcohol.
http://www.lef.org/m...theanine_01.htm
Curcumin from turmeric is also a liver protector: No one should be without some curcumin everyday.
http://www.nutraingr...min-may-prevent
An awesome liver supplement for drinking nights from customcapsule would be:
Pills Per Serving: 12
Servings Per Batch: 25
Pills Per Batch: 300
Ingredients %DV
Betaine 2000 MG N/A
Folic Acid 600 MCG 150%
L-Theanine 200 MG N/A
Milk Thistle 400 MG N/A
N-acetyl-L-cysteine 800 MG N/A
Na R-Alpha Lipoic Acid 160 MG N/A
Taurine 2000 MG N/A
Vitamin C 500 MG 833%
Vitamin B6 4 MG 200%
Vitamin B12 20 MCG 333%
Thiamine HCl 5 MG 500%
Riboflavin 5 MG 500%
Niacin 25 MG 125%
Pantothenic Acid 20 MG 200%
Curcumin 800 MG N/A

Split up into 6 pills before and 6 after or you can control the dose by adjusting the #pills you want to use based on how much you drink and exposure to other toxins, genetic makeup, etc...
Should br HIGHLY effective.
Tell me what you think... There are hundreds of studies to support each and every ingredient listed.

[luv2increase]

I might add that methyl donors are important to liver function and detoxification.
These include folic acid, B6, B12 and Trimethylglycine.
Another ingredient theanine with a link to lef on theanine and alcohol.
http://www.lef.org/m...theanine_01.htm
Curcumin from turmeric is also a liver protector: No one should be without some curcumin everyday.
http://www.nutraingr...min-may-prevent
An awesome liver supplement for drinking nights from customcapsule would be:
Pills Per Serving: 12
Servings Per Batch: 25
Pills Per Batch: 300
Ingredients  %DV
Betaine    2000  MG  N/A 
Folic Acid  600  MCG  150% 
L-Theanine  200  MG  N/A 
Milk Thistle    400  MG  N/A 
N-acetyl-L-cysteine    800  MG  N/A 
Na R-Alpha Lipoic Acid    160  MG  N/A 
Taurine  2000  MG  N/A 
Vitamin C    500  MG  833% 
Vitamin B6    4  MG  200% 
Vitamin B12    20  MCG  333% 
Thiamine HCl    5  MG  500% 
Riboflavin    5  MG  500% 
Niacin    25  MG  125% 
Pantothenic Acid    20  MG  200% 
Curcumin    800  MG  N/A

Split up into 6 pills before and 6 after or you can control the dose by adjusting the #pills you want to use based on how much you drink and exposure to other toxins, genetic makeup, etc...
Should br HIGHLY effective.
Tell me what you think... There are hundreds of studies to support each and every ingredient listed.

Certain things need to be taking before drinking. Certain things "can" be taken during drinking. Certain things "could possibly" be taken the next day.

The n-acetyl-cysteine should not be taken during or right after drinking. The next day shouldn't be a problem. I don't know about the niacin either. It puts a little stress on the liver. I don't think it would be that great to take during this period.

Your custom capsule "one size fits all" concoction doesn't suffice much here. I'd up the vit C dose as well. 20mcq b12??? Where did u come up with these numbers? lol

[kenj]

I'm still leary about some supplementation post-drinking. Ethanol metabolism is weird enough that I prefer to keep to water/sleep instead of a multitude of anti-hangover supplements.

If I drink more than 2 glasses of red wine for example, I take no supplement several hours (+8) after -- just in case. Interestingly, I become quite ill ("cheap drunk") if I hit more than 2-3 glasses now.
Alcohol + (herbal) supplements/drugs should never be mixed, IMO, unless you want a "therapeutic" effect from a supplement (and a small dose of alcohol).

[rfarris]

I get this stuff from Relentless Improvement (~$14):

-----
Anti-Alcohol Antioxidants with HepatoProtection Complex

Consuming alcoholic beverages results in the generation of free radicals. People who drink a lot of alcohol often suffer a hangover because of massive free radical-induced cellular damage.

Alcohol-induced free radical assault can wreak short-term havoc throughout the body, and these same damaging free radicals are associated with accelerated aging.

Astronomical cost of hangovers

A landmark study published in the Annals of Internal Medicine detailed the enormous economic costs of lost productivity attributable to hangovers: "In the United States, related absenteeism and poor job performance cost $148 billion annually (average annual cost per working adult, $2,000)."1

Protecting against alcohol toxicity

A study published in the journal Alcohol demonstrated how antioxidants help to maintain a healthy brain.2 Another study in the journal Artery confirmed a specific toxic metabolite of alcohol (acetaldehyde) and identified an antidote (N-acetyl-cysteine): "All known pathways of ethanol metabolism result in the production of acetaldehyde, a highly reactive compound. N-acetyl-cysteine, an analogue of the dietary amino acid cysteine, binds acetaldehyde, thus preventing its damaging effect on physiological proteins."3

These findings are not surprising, considering that the consumption of alcohol inflicts massive free radical damage throughout the body. When people are exposed to a known toxic substance such as alcohol, it makes perfect sense to take a proven antidote-namely, antioxidants.

Life Extension's Anti-Alcohol Antioxidants with HepatoProtection Complex is an improved formula containing additional antioxidants designed to suppress free radicals, neutralize toxic alcohol metabolites such as acetaldehyde,4-7 and protect against liver toxicity and hepatic injury commonly associated with alcohol consumption. In addition to vitamin B1, vitamin C, N-acetyl-cysteine and benfotiamine, this new formula's HepatoProtection Complex provides potent doses of these novel antioxidants:


Chlorophyllin, an antimutagenic agent that protects the body from oxidative stress than can stimulate cellular mutation.
Leucoselect® grapeseed extract, silymarin (from milk thistle), and resveratrol, three hepatoprotective agents that aid in reducing mutagenic compounds from potentially toxic xenobiotics and protecting cells from free radial-induced oxidative stress.
Picroliv® Picrorhiza kurroa root extract, containing antioxidant kutkins that scavenge alcohol-induced excess free radicals, guard against alcohol-induced damage to cells by lipid peroxidation, and stimulate regeneration of cells (hepatocytes).
Barley grass juice 24:1 extract, which enhances the enzyme aldehyde dehydrogenase, thus inhibiting the formation of acetaldehyde malondialdehyde.

Taking the proper supplements before and after drinking can substantially mitigate hangover effects experienced by people suffering from acute alcohol toxicity.

Supplement Facts
Serving Size 6 capsules

Servings Per Container 16

Amount Per Serving
Vitamin C (as ascorbic acid) (Roche)
3000 mg

Vitamin E (as D-alpha tocopheryl)
50 IU

Thiamin (vitamin B1)(as thiamine HCl)
1000 mg

Selenium (as selenium selenate)
25 mcg

N-acetyl-L-cysteine
600 mg

Glutathione (reduced)
50 mg

Benfotiamine
50 mg

HepatoProtection Complex


Chlorophyllin (from sodium copper chlorophyllin)
100 mg

Leucoselect® Grapeseed extract
20 mg

(Vitis vinifera) [standardized to 95% proanthocyanidins (19 mg)]

Silymarin
20 mg

[from Milk Thistle (Silybum marianum) seed extract]


Picroliv® Picrorhiza kurroa root extract
15 mg

[standardized to 4% kutkin (0.6 mg)


Barley grass juice 24:1 extract powder
15 mg

Resveratrol [from whole red grape
5 mg

(Vitis vinifera) and Polygonum cuspidatum root extract]

Other ingredients: gelatin, magnesium stearate, rice flour.

This product contains NO wheat, yeast, gluten, corn, dairy. Contains NO sugar, artificial color, sweetener, flavors or preservatives.


Leucoselect® is a registered trademark of Indena USA. U.S. Reg No. 2294439.
Picroliv® is a registered trademark of Sabinsa Corp.

References
1. Wiese JG, Shipak MG, Browner WS. The alcohol hangover. Ann Intern Med. 2000 Jun 6132(11):897-902.
2. Altura BM, Altura BT. Association of alcohol in brain injury, headaches and stroke with brain-tissue and serum levels of ionized magnesium: a review of recent findings and mechanisms of action. Alcohol. 1999 Oct;19(2):199-30.
3. Vasev S, Mian T, Longerich L, et al. N-acetyl-cysteine attenuates ethanol induced hypertension in rats. Artery. 1995; 21(6):312-6.
4. Wickramasinghe SN, Hasan R. In vivo effects of vitamin C on the cytotoxicity of post-ethanol serum. Biochem Pharmacol. 1994 Aug 3;48(3):621-4.
5. Mitchell JJ, Paiva M, Heaton MB. The antioxidants vitamin E and beta-carotene protect against ethanol-induced neurotoxicity in embryonic rat hippocampal cultures. Alcohol. 1999 Feb; 17(2):163-8.
6. Shman'ko, W. The selenium content of the body in experimental animals and its effect on the functional biochemical status of the liver in toxic injury. Fiziol Zh. 1996; 42(12):65-72.
7. Agar E, Boznak M, Amanvermez R, et al. The effect of ethanol on lipid peroxidation and gluathione level in the brain stem of rat. Neuroreport. 1999 Jan 3;10(8):1799-801.

Dosage and Use
Take one capsule with each alcoholic beverage.

A maximum of six capsules per day.

If no capsules are taken with alcoholic beverages, take six capsules at bedtime.

[ageless]

I might add that methyl donors are important to liver function and detoxification.
These include folic acid, B6, B12 and Trimethylglycine.
Another ingredient theanine with a link to lef on theanine and alcohol.
http://www.lef.org/m...theanine_01.htm
Curcumin from turmeric is also a liver protector: No one should be without some curcumin everyday.
http://www.nutraingr...min-may-prevent
An awesome liver supplement for drinking nights from customcapsule would be:
Pills Per Serving: 12
Servings Per Batch: 25
Pills Per Batch: 300
Ingredients   %DV
Betaine    2000  MG  N/A 
Folic Acid   600  MCG  150% 
L-Theanine   200  MG  N/A 
Milk Thistle    400  MG  N/A 
N-acetyl-L-cysteine    800  MG  N/A 
Na R-Alpha Lipoic Acid    160  MG  N/A 
Taurine   2000  MG  N/A 
Vitamin C    500  MG  833% 
Vitamin B6    4  MG  200% 
Vitamin B12    20  MCG  333% 
Thiamine HCl    5  MG  500% 
Riboflavin    5  MG  500% 
Niacin    25  MG  125% 
Pantothenic Acid    20  MG  200% 
Curcumin    800  MG  N/A

Split up into 6 pills before and 6 after or you can control the dose by adjusting the #pills you want to use based on how much you drink and exposure to other toxins, genetic makeup, etc...
Should br HIGHLY effective.
Tell me what you think... There are hundreds of studies to support each and every ingredient listed.

Certain things need to be taking before drinking. Certain things "can" be taken during drinking. Certain things "could possibly" be taken the next day.

The n-acetyl-cysteine should not be taken during or right after drinking. The next day shouldn't be a problem. I don't know about the niacin either. It puts a little stress on the liver. I don't think it would be that great to take during this period.

Your custom capsule "one size fits all" concoction doesn't suffice much here. I'd up the vit C dose as well. 20mcq b12??? Where did u come up with these numbers? lol

I'll get to the lol part after, but first where do you get your info? Certainley I have not read that in any scientific literature I have come across... and I have read quite a bit.
Not only are these compound all non-toxic in a sensible dose, but quite the opposite, they work synergistically to enhance liver function, detoxification and protection.
I have taken 'that NAC thing' as you referred to it in an earlier post, during and after drinking with phenomenal results that, while not advised, allow me to drink more and have less negative effects.
If you 'don't know about the niacin', well I do: It is completely safe in the given amount which is just a notch above the DRI and less than the upper limit of safety for niacin established by the Food and Nutrition Board of the Institute of Medicine, which is 35 mg daily for adults.
AOR's top-notch Ortho Core multi has much more niacin.
Liver problems are only likely to occur with time-released versions and at high doses mind you.
Vitamin C is saturated at relatively low levels and taking more at once only results in less % absorbed so I came to the 250mg # by taking such studies into account. One 250mg dose before and then another many hours after should allow for complete saturation of C stores unless one is already deficient. I'm not a fan of high dose C supplementation, but one could always adjust based on 'personal' preferences.
Ok, regarding the lol, I might again refer to what knowledgeable experts here consider the Rolls Royce of Multivitamins, AOR's Ortho Core which comes with 24mcg of the same form of B12 as custom capsule... so it doesn't take a big leap in judgement to realize 20mcg is a logical dose to work alongside the other methyl donors. While it is 333% DV I also think one could also very easily increase this dose safely if wished.
I didn't use high doses of any B's and kept them near safe and accepted ranges. That's where I got those numbers.

I think most healthy people would benefit from my formulation and I realize the science is there to back it up. I hope this helps the original poster as intended and not just to waste my time.

Your earlier water idea, while not new or unknown, is an important one to consider and I agree with you on that.

[kyunghei]

N-acetyl-cysteine used "BEFORE" drinking would be great along with some b-vitamins.  Don't use nac while drinking or after!

Uh, Why not during or after? NAC is administered orally by doctors in the emergency room in cases of both alchohol poisoning and acetaminophen overdose (since they both utilize the same metabolic pathways). It is only effective as a treatment if administered within 8 hours of alcohol/acetaminophen consumption - afterwards it is too late! If my liver should run out of cysteine or if I outpace my body's ability to create cysteine fast enough, the only thing that will prevent my liver or kidneys from becoming damaged by acetaldehyde is to take NAC or glutathione WITHIN the timeframe that acetaldehyde is still within my bloodstream - which would only make it effective to take it either during or after I have consumed the alcohol. Taking it the next day would be too late to prevent damage and my body will break it down as "excess" if I take it before I have begun to use my liver's own stored cysteine.

I realize I'm coming to this conversation late, but I had to comment on this because I have been making my own alchohol damage preventative capsules for years. I make them from NAC, Vitamin C, Vitamin B1, and trace amounts of copper and zinc. It works wonders! And I often take them during or after I drink alcohol. I will continue to do so!

Here are a few articles (with sources) on the subject of NAC to protect against acetaldehyde toxicity (from alcohol consumption, I'm implying):

http://intelegen.com...effects_of_.htm
http://www.ceri.com/alcohol.htm
http://www.lef.org/p...prtcl-004.shtml

Edited by kyunghei, 01 May 2007 - 11:17 PM.

[shifter]

I dont know if it means anything but...
When I have taken tribulus, maca & MSM, I find it takes much more alcohol for me to feel the effects of being tipsy. (in earlier times, 2 white wines in 5mins followed by a few shots of absen and tequilla). The same combination had me smashed in 5 minutes, as opposed to barely feeling anything when taken the supps.

If I have had nothing, it takes just the one glass of white wine for me to feel a bit on the tipsy side.

Dosages of tribulus was 40grams (equiv whole plant) and a table spoon of maca and 2 teaspoons of MSM.

odd?

edit: should add that it didn't prevent me from feeling tipsy/drunk, just that it took more and took longer and that I dont drink anymore (tried it a few times, felt the good/bad experiences so now its just a 'been there done that').

Edited by shifter, 02 May 2007 - 05:50 AM.

[brianmdelaney]

N-acetyl-cysteine used "BEFORE" drinking would be great along with some b-vitamins.  Don't use nac while drinking or after!

A few people here have claimed either that it is important to take NAC before drinking (not unreasonable) or that is important not to take NAC while drinking. I have seen zero evidence for the latter claim. Can anyone provide some?

Thanks,
Brian

[tothepoint]

N-acetyl-cysteine used "BEFORE" drinking would be great along with some b-vitamins. Don't use nac while drinking or after!

A few people here have claimed either that it is important to take NAC before drinking (not unreasonable) or that is important not to take NAC while drinking. I have seen zero evidence for the latter claim. Can anyone provide some?

Thanks,
Brian

Bump. Why avoid taking NAC after drinking? Especially considering what kyunghei said?

[yoyo]

Could someone explain why NAC should not be taken once one is blitzed.

I have seen this said but not the reason why.

[unbreakable]

I think it's optimal to take NAC before, while and after drinking (when there is still ethanol/acetaldehyde in the system). Optionally you can take it before and after consuming larger quantities of alcohol. Drink much water too.

Edited by unbreakable, 12 January 2008 - 10:33 AM.

[caston]

I've decided i'm not going to drink again. Basically it's good for neither the germline nor the soma. It can also cause havoc with your sexual functions or put you in situations where other drinkers may act violent and or sexual towards you that otherwise wouldn't.

So I'm not going to recommend any supplements to help you look like a hero that can hold down his liqour and still get the girl i'm going to recommend avoiding the negative effects of alcohol by simply avoiding alcohol.

Edited by caston, 12 January 2008 - 12:53 PM.

[abelard lindsay]

Here's a very through and technical summary of what alcohol does to the body and mind and how its affects can be mitigated:

http://www.bodybuild...om/fun/par7.htm

Piracetam has also been show by numerous studies as a way to reverse the neurotoxic effects of alcohol.

[Cardioprotective effect of GABA derivatives in acute alcohol intoxication]
[Article in Russian]

Perfilova VN, Tiurenkov IN, Berestovitskaia VM, Vasil'eva OS.

Cardioprotective properties of GABA analogs under conditions of acute alcoholic intoxication have been studied using the following functional tests: volume loads, tests for adrenoreactivity, and maximum isometric load. The experiments showed that a 32% aqueous ethanol solution intraperitoneally injected in a dose of 8 g/kg produces a cardiotoxic action, which is manifested by a decrease in the inotropic reserve in load tests. Citrocard (50 mg/kg), phenibut (50 mg/kg), and piracetam (200 mg/kg) prevent the alcohol-induced myocardium injury, as shown by the heart contractility retained on a higher level in the test group than in the control group.

[Cognitive function in alcoholics in a double-blind study of piracetam]
[Article in Croatian]

Buranji I, Skocilić Z, Kozarić-Kovacić D.

Klinicki psiholog, Klinicka psihijatrijska bolnica Vrapce, Zagreb, Bolnicka.

The effects of piracetam on cognitive functions have been studied in alcoholic patients. The investigation was carried out on 27 alcoholics who were admitted to hospital with acute withdrawal syndrome. The trial was performed under double-blind condition. Thirteen patients were treated with piracetam and 14 with placebo. The performance of patients treated with piracetam (experimental group) was significantly better at the Block-Design retest, as compared with the control subjects. This was associated with comparatively good perceptual organization, visual motor coordination and abstract reasoning in these patients. Similar kind of performance of these patients has been achieved in the tests used to measure psychomotor speed and attention capacity. Our findings agree well with some observations of the clinicians and may stimulate further research in this field.

[rabagley]

I've decided i'm not going to drink again. Basically it's good for neither the germline nor the soma. It can also cause havoc with your sexual functions or put you in situations where other drinkers may act violent and or sexual towards you that otherwise wouldn't.

So I'm not going to recommend any supplements to help you look like a hero that can hold down his liqour and still get the girl i'm going to recommend avoiding the negative effects of alcohol by simply avoiding alcohol.

I'm always confused by statements like this one. Are you confusing "drink" with "get drunk"?

One to two drinks a day are not correlated with any negative physiological effects and are correlated with multiple positive effects. So why not have a glass of wine with your dinner if you like the taste and it makes dinner that much more enjoyable? If you prefer the taste of a particular mixed drink, beer, or a liqueur, have that with or after the meal, as appropriate.

One drink with dinner does not play havoc with your sexual functions (unless being a little more relaxed counts as "havoc"). A drink with your meal does not put you in any situations, ever. Also, "looking like a hero" and "hold down his liquor" are opposite adjective phrases, not similar phrases. People who can drink a lot of alcohol and not appear completely drunk are morons. Alcoholism runs in my wife's family, and I know of what I speak.

I recommend avoiding the negative effects of heavy alcohol consumption and receiving the positive effects of moderate alcohol consumption by consuming moderate quantities of alcohol. Upper limit of two drinks in any 24 hour period makes this a trivially easy goal. Now, there are some people who don't have the self-control to limit themselves to one or two drinks. I don't think this is nearly as common as AA would have you believe, but I agree there are people like that. These poor individuals should not try to drink in moderation and should instead completely abstain.

[caston]

Yes, in the past I have become drunk on many occasions. I am also a lonely drunk and start sms'ing females in my address book when I start drinking which must be a major annoyance to them.

I will completely abstain from alcohol and if there are any positive effects to be found in drinking I will achieve such positive effects through alternate means.

Edited by caston, 13 January 2008 - 02:48 AM.

[Alien65]

I enjoy my daily Brandy Manhattans but this is the anti-alcohol regimen I take with my drinks:

Silymarin 250 - 500 mg
N-Acetyl Cysteine 750 mg with 1500 mg Ester C
Coenzyme B Complex
Trans-Resveratrol 100 mg (synergistic with Brandy)

I used to take the LEF Anti-alcohol formula which is good but comes in a gelatin capsule. (Because I take so many supplements, I used to have constant 'runs'. Since switching everything to veggie caps and minimizing tablets, my digestive system has normalized and the problem went away).

This is only a part of a much larger supplement regimen that I consume for specific conditions and purposes.

Edited by Alien65, 14 January 2008 - 06:25 AM.

[mitkat]

I just picked up AOR's new Ortho-Liver:

SUPPLEMENT FACTS:
Serving Size: 2 Capsule
__________________________________________

Metadoxine ...........................................................333 mg

Milk Thistle Dry Extract(standardized for 40% Silibinin)... 210 mg

Schizandra (standardized for 2% total schizandins)....... 167 mg

Artichoke Leaf (standardized for 5% cynarin).............. 167 mg

Trimethyglycine (betaine anhydrous) ..........................333 mg
N-acetyl-cysteine (NAC) ..........................................400 mg

Not that this would be taken post-drinking, but more on a regular basis. I don't take an NAC currently so I am using it for that also.

[johnyq]

What about SAM-e ?