Just wondering what the general consensus is as to how many times a day we should be dosing. I am aware of aware that we may want to be overloading the first past of the liver with a large does, but at some point would it make sense to split the dose? For instance, I think I will be going to 600mg/day. Best to take one 600 in the morning, or two 300mg does, or perhaps 3 200mg doses. IOW, once we overload the first-pass of the liver for a given dose, is there a limit to the benefit from the t-res? If it takes 100mg to overload the liver, then why would 400mg be better than 300mg?
Also, any sense of the risk/reward ratio of going beyond 5mg/kg in total for the day?