19 replies to this topic

[davie1a]

Hi,

I am new to this forum, its certainly great to meet minds that think alike.

I am looking for the best high quality and value for money place to buy reservatrol.

Can you recommend any good suppliers?

Also is Synthetic better than natural?

I want to take the high dose life extention amounts like 1g / day

I live in the UK.

Thanks,

Alex.

[tintinet]

Synthetic was used in Sinclair's rodent studies, but natural plant derived extracts are less expensive and more widely available.

Check out the pricing comparison website Anthony Lowera of RevGenetics has posted for some supplier links:

RSV Price Comparison Site

[davie1a]

Thanks,

Alex.

[curious_sle]

Wow, that comparison chart really took off... kudos to Anthony!

[mike250]

what about biotest's res-v?

[tintinet]

Wow, that comparison chart really took off... kudos to Anthony!

BTW, I have been in communication with James Betz of Biotiva/Bioforte.

Some selected excerpts:

"We strive to bring our cis-resveratrol content down to virtually nill. Our raw material specifications which our suppliers agree to call for no cis isomer however given normal HPLC test deviations a level of around 0.6% - 1.5% is acceptable and normal. We process our raw material through one additional proprietary step which both reduces emodin and transforms residual cis isomer into the trans isomer. I am relatively certain that no other processor is doing this. The process itself is an extension of the process that a couple of the better raw material manufacturers utilise to maximise trans-resveratrol content in their product and it is not inexpensive nor particularly quick as it must be done in our lab, not in the processing plant. Our internal specs call for each capsule to contain 500mg of resveratrol which includes polydatin, some residual cis-resveratrol and trans-resveratrol. If meeting our specs dictates a total capsule weight (minus the 91mg capsule weight) of slightly more than 500mg and/or addition of more than the usual amount of 98-99% resveratrol to the material our processing parameters are adjusted accordingly. Before we can receive permission from the government to export our product to the US or EU, or anywhere else for that matter, we must provide samples for testing in their lab. Their results must conform to our label specifications for the permission to be granted. This is in addition to our own tests."


Perhaps this information resolves the uncertainty Anthony felt regarding prior statements by Bioforte/Biotiva, and compelled him to remove Bioforte from his comparison list.

[Anthony_Loera]

He mentioned that it the 500mg was pure Resveratrol.

According to the label here which the governement would check:
http://www.revgeneti...BioforteNew.jpg

It still does not convince me.

That is like saying that our RevGenetics R500 contains 1000mg of pure Resveratrol, when only 500mg is Trans-resveratrol.

Although it is a fine line, the label is what matters to the FDA when doing any investigation. It is after all, what the public basis their decision on.

The decision to take it off of the list was really made by Bioforte, you seem to be forgetting the email sent by James to RevGenetics stating that his product contained 500mg was pure Resveratrol, when in fact the powder is (from the label itself) "Polygonum Cuspidatum".

Here again is his email to me:

===========================
Dear Anthony,
Please be advised that you grossly misrepresent our product on the
comparison chart on your site. Specifically our product contains 500
mg of total resveratrol, of which 250mg is trans-resveratrol. Please
correct this error immediately or we shall seek legal recourse, as we
have against other companies which have misrepresented our product.
Regards, James

cc. Kenneth , Quin and Hampson Barristers
Anne Devereau
Roger Day

============================

What would you do in my position?

Anthony

[maxwatt]

He mentioned that it the 500mg was pure Resveratrol.


Here again is his email to me:

===========================
Dear Anthony,
Please be advised that you grossly misrepresent our product on the
comparison chart on your site. Specifically our product contains 500
mg of total resveratrol, of which 250mg is trans-resveratrol. Please
correct this error immediately or we shall seek legal recourse, as we
have against other companies which have misrepresented our product.
Regards, James

cc. Kenneth , Quin and Hampson Barristers
    Anne Devereau
    Roger Day

============================

What would you do in my position?

Anthony

I would change the column heading to say "Amount of trans-resveratrol", and footnote it, to say as stated on teh product label.

I would ignore the barrister until he sends another letter.

[Anthony_Loera]

I don't want to knock a whole lot of people off of the list.

Let me see how to change the sheet around then...

[tintinet]

Do you think it is not possible to have a 500(+ a bit) mg capsule containing 50%, at least of trans-resveratrol accompanied by a very small amount of cis-resveratrol and the bulk of the remainder consisting of the polydatin form of resveratrol?

ISTM we are primarily interested in 1. amount of trans-resveratrol, 2. any toxic contaminants, 3. emodin content, no?

[malbecman]

Wow, that comparison chart really took off... kudos to Anthony!

I agree, thanks Anthony. You have done a real service to the community by providing this comparison!



I also agree with Maxwatt, ignore the threat of Bioforte firing their lawyer-pult at you. Its just blustering at this point and
is making them look bad to us, the potential buyers......

[tintinet]

Wow, that comparison chart really took off... kudos to Anthony!

I agree, thanks Anthony. You have done a real service to the community by providing this comparison!.

Absolutely!

I also agree with Maxwatt, ignore the threat of Bioforte firing their lawyer-pult at you.  Its just blustering at this point and
is making them look bad to us, the potential buyers......

Agree it's bluster, and not very civil, either. They might have just politely given you their analysis of their product to post in place of what you had.

[niner]

Agree it's bluster, and not very civil, either. They might have just politely given you their analysis of their product to post in place of what you had.

Yeah. It makes me suspect that they don't want people to know what's in their product, or they don't know themselves. Either way, I wouldn't touch their stuff with a ten foot pole.

[PWAIN]

Do you think it is not possible to have a 500(+ a bit) mg capsule containing 50%, at least of trans-resveratrol accompanied by a very small amount of cis-resveratrol and the bulk of the remainder consisting of the polydatin form of resveratrol?

What exactly is the polydatin form of resveratrol? Is it actually the resveratrol moleclue in a different configuration? If so does anyone know if it has any effects?

[proteomist]

It's resveratrol with a sugar molecule attached to one of the OH groups. As far as I know, nobody knows if it has significant effects.

Do you think it is not possible to have a 500(+ a bit) mg capsule containing 50%, at least of trans-resveratrol accompanied by a very small amount of cis-resveratrol and the bulk of the remainder consisting of the polydatin form of resveratrol?

What exactly is the polydatin form of resveratrol? Is it actually the resveratrol moleclue in a different configuration? If so does anyone know if it has any effects?

[PWAIN]

I just did a quick google on polydatin, seems that it may be good for something:

http://www.ihop-net....l?pmid=16870162

Protection of the brain from shock.

[Anthony_Loera]

Do you think it is not possible to have a 500(+ a bit) mg capsule containing 50%, at least of trans-resveratrol accompanied by a very small amount of cis-resveratrol and the bulk of the remainder consisting of the polydatin form of resveratrol?

ISTM we are primarily interested in 1. amount of trans-resveratrol, 2. any toxic contaminants, 3. emodin content, no?

The tough part is that the FDA really only looks at labeling for investigations. So if it's not in the label, it may simply not be there...
The NPA (Natural Products Association) has a true label program that works the same... they boot you from their association if they find your label is different than your actual formula.

When I modify the excel sheet, I will check labels, and add the info to the sheet... but really that is all I can check unless someone sends me a COA...

Thanks
Anthony

[EmbraceUnity]

I just did a quick google on polydatin, seems that it may be good for something:

http://www.ihop-net....l?pmid=16870162

Protection of the brain from shock.

Your website claimed the following:

"These results suggest that polydatin exerts protective effects likely via inhibition of the expression of various CAMs"


I just checked Wikipedia about Cell Adhesion Molecules...


"Mental retardation and other neurological disorders are attributable in part to disruption of normal cell adhesion"


I am no expert obviously, but it seems like something to be careful with.

[tintinet]

Especially if yer mentally retarded!

[edward]

CAMs really don't appear to be something one wants to mess with.

From my Anatomy and Physiology Textbook (paraphrased):

Thousands of CAMs are found on almost every cell in our body, they act as molecular velcro that holds cells together and within extracellular space, they also act as arms that allow migrating cells to move amongst more stationary cells, they act as mechanical sensors that respond to tension on the cells surface by causing synthesis or degradation of adhesion membrane junctions, they also can act to transmit messages intracellularly to direct cell migration, proliferation adn specialization.