I hope that subtitle is taken as the gentle, friendly ribbing I intend [lol]. There's been lively debate on here recently as to appropriate resveratrol dosage. Some of those opposed to these dosage levels have speculated that people taking 1000mg or more a day may be doing so at grave peril to their health, or are otherwise 'crazy' to do so. Some others have taken a conservative, measured wait-and-see approach and are reserving judgement. Others, anxious to get the benefits of Sirt1 activation without waiting, have speculated that appropriate doses are on the 1-5 gram scale, based on the published literature and have been experimenting at those levels.
Well, add Sirtris to the 'crazy' list. Their Phase Ib trials for resveratrol against diabetes were conducted with either 2.5g or 5g per day of SRT501, the resveratrol formulation they claim yields substantially elevated blood levels as compared to plain resveratrol. So we're talking about levels you might get with roughly 5-50 grams per day. Their study for MELAS, a mitochondrial disorder, were conducted with five grams per day.
So, who else want to join the >1000 mg club?
Edit: Hat-tip to Paragon for noticing these dosage indications in the Sirtris IPO Roadshow, and Malbecman for posting the link to the presentation in the first place.
Edited by proteomist, 11 May 2007 - 09:38 PM.