5 replies to this topic

[Fredrik]

There´s been a lot of discussion in the past about nicotinamide negating the SIRT1 activating effect of resveratrol. But to treat certain neurological disorders David Sinclair suggests combining sirtuin activating compounds, like resveratrol, with nicotinamide or NAD supplements. So using nicotinamide (vitamin B3) with resveratrol or other STACs doesn´t seem to be a total no no.

This paragraph below is from a patent filed 2005, "Sirtuin related therapeutics and diagnostics for neurodegenerative diseases", inventor David Sinclair (amongst others).


[1213] Other combination therapies include conjoint administration with nicotinamide, NAD.sup.+ or salts thereof, other Vitamin B3 analogs, and nicotinamide riboside or analogs thereof. Carnitines, such as L-carnitine, may also be co-administered, particularly for treating cerebral stroke, loss of memory, pre-senile dementia, Alzheimer's disease or preventing or treating disorders elicted by the use of neurotoxic drugs. Cyclooxygenase inhibitors, e.g., a COX-2 inhibitor, may also be co-administered for treating certain conditions described herein, such as an inflammatory condition or a neurologic disease.

United States Patent 20060025337.

http://www.freepaten...ein&stemming=on

[maxwatt]

You have to be very careful with drawing conclusion from patents. They tend to make claims for any conceivable variation, to make the claims as broad as posible, and are under no obligation to actually test what they are claiming. The date of the patent is 2005, and the antagonistic effects of niacinamide were not published until a few years later: unlike niacinamide, nicotinamide riboside has been shown to activate SIRT1.

[Fredrik]

The date of the patent is 2005, and the antagonistic effects of niacinamide were not published until a few years later: unlike niacinamide, nicotinamide riboside has been shown to activate SIRT1.

Not true. Dr david Sinclair co-authored the paper "Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1." published in 2002.

PMID: 12297502

So it´s kind of strange that he still suggests using nicotinamide in that patent three yeras later. But I agree with your first statement, they often use the kitchen sink approach when writing patent applications.

[edward]

The above quoted patent application mentions Nicotinamide Riboside and other (not specific miscellaneous) B3 analogues. It does not mention Niacinamide/Nicotinamide unbonded to other chemicals. From what I read in my extensive quest to find the truth about the Niacinamide question is that the B3 analogues (there are a lot of them) each have different actions and pathways and thus are not interchangeable (though they do have overlaps) even though they are often interchanged on labels, in formulas and in articles.

[Fredrik]

I don´t mean to be a besserwisser but the patent application clearly DO mention both nicotinamide AND nicotinamide riboside and various B3 analogues:

"[1213] Other combination therapies include conjoint administration with NICOTINAMIDE, NAD.sup.+ or salts thereof, other Vitamin B3 analogs, and nicotinamide riboside or analogs thereof...."

I don´t take nicotinamide myself and I don´t propose that anyone do either. I just thought this suggestion was peculiar, as Sinclair himself previously suggested accelerated aging by nicotinamide. It was just an observation, we can leave the subject if no one has new information and just want to argue for arguments sake.

Edit: changed "rude" to "besserwisser"

[edward]

You are right, my bad. Well your guess is as good as mine. I'm still on a nicotinamide/niacinamide free diet.