12 replies to this topic

[ronb]

http://www.ebiologynews.com/2367.html

So does anybody know if it's possible to obtain the material discussed in the above link?

-r

[Gerald W. Gaston]

It has been around and discussed here. One vendor posted their product "announcement" here:

http://www.imminst.o...l=oxytocin&st=0

[nozza]

I'm not sure I trust that Oxycalm product. I'd be more interested in getting the pure stuff but it all seems to be tied up in vetinary pharmacies which appear to be more tightly controlled than the human ones. Does anyone have links to any more open overseas vetinary pharmacies?

[caston]

why not put it in perfume?

[Shepard]

why not put it in perfume?

Like all the pheromone products on the market, it's not really effective unless taken directly (nasal spray).

I don't know the intentions the original poster has, but this would probably be more suited to making an individual feel an emotional connection instead of what I would consider overcoming shyness. There are certainly compounds you could put into a nasal spray to become more outgoing in a sense, but I'm not saying anything along that line.

[shuffleup]

why not put it in perfume?

Like all the pheromone products on the market, it's not really effective unless taken directly (nasal spray).

I don't know the intentions the original poster has, but this would probably be more suited to making an individual feel an emotional connection instead of what I would consider overcoming shyness. There are certainly compounds you could put into a nasal spray to become more outgoing in a sense, but I'm not saying anything along that line.

Tease.

[overkillx7]

Total waste of money....trust me i got one before, worthless. I cant believe I even bought it.

[AIGuy]

My question, has anyone experimented with the new Oxytocin sprays that
are appearing on the market?
The hormone itself seems to have a lot of scientific evidence supporting it.

http://www.socialbeh...d-reading06.pdf

http://www.nature.co...e050602-13.html

http://en.wikipedia.org/wiki/Oxytocin

http://brainethics.w...ow-to-the-soul/

http://www.reuniting..._health_bonding

http://www.smh.com.a...6956247384.html

But the advertising of the sprays is pretty cheesy and I wonder how they're getting synthesizing

or extracting the hormone in sufficient concentration to actually do anything.

And at $50 I'd feel less silly if someone else admitted to trying it first.

http://www.verolabs.com/

I was also surprised to find injectable versions called Pitocin and Syntocinon which it seems is being used to induce labor.

http://www.rxlist.co...ic/oxytocin.htm

Best Regards,

Gary

[shifter]

I used to give ~2ml Oxytocin to pigs that had trouble giving birth or letting milk down or was over agressive/anxious to get down to feed the piglets. Perhaps Oxytocin can work in humans but I am guessing it has more wide reaching effects on the body than simply overcoming shyness (probably does that indirectly or is a side effect from something else it has done eg a relaxant). Wouldn't you want something that stimulates you, rather than something that makes you dopey?

Also these were 'mini pigs' and weighed much the same as a 70-80kg human (or less as full grown adults). So if a few mls did the trick to pigs of much the same size, whats a few drops in a nasal spray thats probably mostly NOT Oxytocin going to do? Probably not a lot. (a glass of wine probably does a better job).

Can this be orally ingested anyway? hehe

[Futurist1000]

Apparently it makes people more trusting of each other.
Oxytocin Trust

Experts think that oxytocin exerts its range of effects by boosting some social behaviours: it may encourage animals or people to overcome their natural wariness when faced with a risky situation. The theory argues that people only decide to trust each other - when forming a sexual or business relationship, for example - when the brain's oxytocin production is boosted.

It also seems to have an effect on a woman's sex drive.

From animal studies it has been hypothesized that oxytocin may have behavioral effects on sexual arousal, orgasm, and social bonding (Carter, 1992; Carter, Williams, Witt, & Insel, 1992). Anderson-Hunt and Dennerstein (1994, 1995) published some notes about the sexual effects of a synthetic oxytocin (nasal) spray in a woman who took the drug for low milk expression during lactogenesis. Two hours after taking the spray she observed abundant vaginal lubrication, followed by intense desire and intensified contractions during orgasm and heightened pleasure.

Oxytocin

[fast turtle]

Hard to get through the BBB, rapidly metabolized in the cerebral cortex if it gets there anyway (peptide). Maybe with some work it could be a better agonist and then encapsulated into nanoparticles to reach the brain better. As of now, don't waste any money, you'd probably get a much better effect taking an ecstasy pill (which releases oxytocin). Not that'd I'd recommend that either..

[ikaros]

From Wikipedia:

Certain learning and memory functions are impaired by centrally-administered oxytocin

This alone makes me want to stay away from it. Oxytocin won't win my TRUST!

[theta]

I've used oxytocin nasal spray and my readings of another person's
blog and my own web research seems to confirm that it has a half-life at most of 5 minutes. Which other than to reduce your social
anxiety briefly to beable to make a phone call its not useful. A
pharmaceutical company is developing an analog of oxytocin that will have a much longer half-life. So until that is available or there
is some other long acting oxytocin agonist available I would not
put much hope in oxytocin approach to treating social anxiety.

http://en.wikipedia....wiki/Carbetocin

Wikipedia list its half-life at 40 minutes.

Here is a patent that list some experimental non-peptide oxytocin
agonists.

http://www.freepaten...cin&stemming=on

Edited by theta, 07 October 2007 - 04:22 AM.