11 replies to this topic

[kottke]

I Added 5mgs deprenyl to my supplement regimen four days ago and im feeling pretty good i have to say. It has seriously helped with my overall concentration, memory, and coordination. The only downside is that it slows my breathing down throughout the day and that worries me because of sub-optimal oxygen absorption.

A few theoretical issues have come up that I hope someone would be so kind to address

1) Is there a way to counteract the breathing suppression that selegiline brings on?

2) Would adding bacopa for anxiety be a bad choice do to excessive SOD production or other antioxidant systems?

3) Would adding rhodiola be dangerous to it's ability to raise serotonin to such a significant degree and its possible MAOI properties?

4) Is deprenyl really better absorbed with food?

And an added question

5) Would bacopa quench the acetylcholine needs similar to citicoline (or any choline precursor) for my piracetam dosages?

Thanks in advance

Edited by kottke, 28 July 2007 - 08:22 PM.

[kottke]

No one has any advice on the above questions?

[kottke]

I know that bacopa increases Ach and everyone knows that without me citing it. So if piracetam supposedly uses up Ach quickly then wouldn't any stimulator of Ach (acetylcholine) work? Like amphetamines and cocaine stimulate the release of dopamine without tyrosine, vitamin C and other B cofactors which are needed to synthesize dopamine daily.

[Shepard]

I don't know about the breathing suppression. But, bacopa is probably not necessary with deprenyl, and it's better absorbed with food.

[kottke]

shepard: I'm sure its not needed for added antioxidant protection but i was looking to use it for its anxiolytic effect. The breathing suppression has since ceased.

I tried ashwagandha tonight and its a pretty nice combo for anxiety so far it's just too much antioxidant shit going up there i feel. If im wrong for caution in this area someone please correct me. The only other viable options i see are picamilon, large doses of GABA itself, or possibly aniracetam. Not taking piracetam and choline helped a bit today. These are to counter anxiety by the way. I looked into Rhodiola and im not too scared about it causing serotonin syndrome, i just was being overly cautious i think.

Would fish oil or whey count as "with food" on some level?

[ortcloud]

So are you feeling better because of the methamphetamine that the deprenyl metabolizes into ?

[kottke]

So are you feeling better because of the methamphetamine that the deprenyl metabolizes into ?

Ummm....I'd have to ask my liver....

[nozza]

The sort of questions you ask could only be answered accurately by some pretty intensive scientific research. The biochemistry and neurochemistry involved is complex to say the least. You can't just look at these substances in terms of their supposed gross effects, like their dopamine or seratonin effects. They have numerous effects that interact with the body's own feedback mechanisms. In fact no-one can even really say exactly how any of them work in their entirity.

E.g. SSRI's are thought to alleviate depresion because of the net increase in seratonin. But other antidepressant drugs operate as serotonin antanogists. On the face of it they act in opposite ways for the same goal which is mystifying. Only by looking at the type of serotonin receptors affected by the drug and how the receptor feedback mechanism interacts with the drug's action to affect other receptors can we have an idea of how it might work.

[shifter]

I have taken 500mg of Rhodiola Rosea (5% rosavins) while on 5mg of Selegiline.

I have also taken 'Pomeratrol' - 200mg Pomegrante and 20mg Resveratrol. I was wondering about that combo given its p450 inhibiting abilities and the use of 'medication' at the same time.

Once a week or fortnight I take some PEA as well and thats the only thing that I have noticed anything. Shallow breathing not one of them.

With the Selegiline on its own or taken Rhodiola and/or Pomeratol I haven't noticed any changes in the way I breathe or any negative effects. The 5mg per day of Selegiline has not made any effect on mood or anything of the sort for me. I one time bumped it up to 10mg for around 3 days with no noticeable effects.

There may have been effects going on that I didn't know about though. Also I dont take Rhodiola and Pomeratrol every day

[kottke]

Ok so after much thought and recurrence of dyskinetic symptoms i have decided to completely drop deprenyl. Not just partially like 1mg a week, but completely. From the literature ive read and the direct symptoms ive felt, continued used of deprenyl can only lead to worsening or even permanent dykinesia for me. It's really sad but it's true and I'm not even going to play games and try to counteract it with choline or vitamin E or whatever proposed combination is put out there: I'm just done.

In fact on top of it causing dykinesia for me it has actually made me minorly psychotic and i fear this is from prior drug abuse and the stimulation of these pathways. I could even kill my ego here and say that i'm just genetically susceptible to these states and drug use only worsened the pathology.

Anyways deprenyl is an interesting drug and people who don't have dyskinesia, major anxiety, or psychotic tendencies should give it a whirl and see what they can create.

[tintinet]

I've been taking it for years (relatively low dose 1 to 5 mg/day) without ever noticing any effects, subjectively.