4 replies to this topic

[mike250]

Carcinogenesis. 2007 Aug 3

Resveratrol Suppresses Prostate Cancer Progression in Transgenic Mice.
Harper CE, Patel BB, Wang J, Arabshahi A, Eltoum IA, Lamartiniere CA.

Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama.

Resveratrol, a natural polyphenolic phytochemical, has been reported to act as an antioxidant and provide anti-cancer activities. We hypothesized that resveratrol would exert a chemopreventive effect against prostate cancer via regulation of sex steroid receptor and growth factor signaling pathways. In the current study, Transgenic Adenocarcinoma Mouse Prostate (TRAMP) males were fed resveratrol (625 mg resveratrol/kg AIN-76A diet) or phytoestrogen-free, control diet (AIN-76A) starting at five weeks of age. Mechanisms of action and histopathology studies were conducted at 12 and 28 weeks of age, respectively. Resveratrol in the diet significantly reduced the incidence of poorly differentiated prostatic adenocarcinoma by 7.7-fold. In the dorsolateral prostate (DLP), resveratrol significantly inhibited cell proliferation, increased androgen receptor (AR), estrogen receptor-beta (ER-beta), and insulin-like growth factor-1 receptor (IGF-1R), and significantly decreased IGF-1, and phospho-extracellular regulating kinase 1 (phospho-ERK 1). In the ventral prostate (VP), resveratrol significantly reduced cell proliferation and phospho-ERKs 1 and 2, but did not significantly alter IGF-1R and IGF-1. Serum total testosterone, free testosterone, estradiol, dihydrotestosterone (DHT), and sex hormone binding globulin (SHBG) concentrations and SV-40 Tag expression in the prostate were not altered in resveratrol-treated mice. Total resveratrol concentration in the blood serum of 12 week old mice treated for three weeks with 625 mg resveratrol/kg diet was 52 +/- 18 nM. The decrease in cell proliferation and the potent growth factor, IGF-1, the down-regulation of downstream effectors, phospho-ERKs 1 and 2, and the increase in the putative tumor suppressor, ER-beta, provide a biochemical basis for resveratrol suppressing prostate cancer development.

PMID: 17675339 [PubMed - as supplied by publisher]

[bionutra]

thanks for the information

I have seen abstracts where resveratrol has been used for breast cancer, pancreatic cancer and melanoma too.

I'm regular consumer of Resverarol and I can feel the difference between chemotherapeutic and natural supplement.

thanks

[efosse]

do you currently have cancer, bionutra?

[austix]

the resveratrol that the mice are getting is not the same as the stuff the rest of us are consuming. Who has the real goods?

[dannov]

"resveratrol (625 mg resveratrol/kg AIN-76A diet)"

That's the only mention to res that I noted in the abstract, and there is no information in that quote that would lead me into thinking that we aren't getting the same Res. Trans-res is Trans-res bro, it comes from nature and is simply harvested. The degree of trans-res in the product is the only thing in question (and that simply varies on filtration). 50%, 98%, 99% are the common percentages of trans-res in a product.