14 replies to this topic

[asnufu]

How 'bout this ? DARPA-funded quercetin snack research. Might be an interesting combo with a resv suspension chaser ...

http://blog.wired.co...al-cures-d.html

[Anthony_Loera]

Thats interesting...

we were studying the pricing for chewing gum with 99% rsv (200mg) a piece...

But the cost is still to high, it would retail at between 5-8 dollars for a pack of 22 pieces "with a fresh minty flavor!"...

We will wait some more until prices drop some more... I don't think we could use 50% rsv right now, it would not taste to good...

A

[nameless]

A rsv gum would be interesting.

Couldn't you make a gum with a lower dose of rsv (25-50mg)/piece at a better price? 200mg a piece seems a bit high to me, as a couple of pieces a day would put you close to gram range. I wonder how the absorption rate would be too... better or worse, than swallowing a pill?

Edited by nameless, 09 August 2007 - 05:12 PM.

[niner]

Somebody ought to look at sublingual absorption of resveratrol. It would be a way to bypass the liver on the first pass through circulation. My main concern with it is a suspicion that because the surface area of the mouth is so much less than the intestine, you would not get as good of a peak blood level. I could be wrong though, as the sublingual concentration would be higher. If you used 99% resveratrol, the taste would not be a problem.

[tintinet]

Where are those wacky patches, BTW?

[ajnast4r]

200mg per piece is too much... as most people, including myself, chew multiple pieces of gum per day...

25. maybe 50mg/piece MAX

[Matt]

Looks good, quite cheap too

[Anthony_Loera]

Hmm... I will check what the price difference for 50mg and 25mg would be...

A

Edited by Anthony_Loera, 14 August 2007 - 04:22 PM.

[tintinet]

Make mine sugar-free, please!

[malbecman]

My main concern with oral dosing of resveratrol is the relatively higher doses "required"/taken by many of us. Here is a quote from a pharmocokinetic paper I have on sublingual absorption, notice the line about potency. (although they did dose their animals in this paper at 2 mg/kg):

The oral cavity has been investigated as an alternative route of delivery for therapeutic small molecules and macromolecules having low oral bioavailability due to poor gastrointestinal (GI) absorption, GI instability, and/or susceptibility to first-pass metabolism.[1-3}

Primary considerations for systemic intra-oral drug delivery are potency (typically dose 5 mg), acceptable taste, reasonable saliva solubility, and membrane permeability. As with drug absorption across other mucosal barriers, fundamental factors that influence intra-oral absorption are pKa and pH for ionizable drugs, drug solubility in the saliva, partitioning into the mucosal membrane, diffusion across the epithelial lining, and residence time at the site of absorption.[

[Anthony_Loera]

Hmm... I will check what the price difference for 50mg and 25mg would be...

A

Ok I checked, it still appears a bit expensive for now, but we will revisit it in a couple months again.

thanks

A

[asnufu]

Anthony, the resv gum idea is worth pursuing, I think - have you considered subcontracting the manufacture to nutravail http://www.nutravail...dicatedgum.html ?

From what we know at this time, spike plasma concentration seems to be more important than cumulative availability ("under-the-curve") - see other threads. Even if this is speculative, I for one would be willing to pay a reasonable premium for a gum formulation if it provided convenience of ingestion and better plasma response, as nutravail seem to suggest

Nutravail can formulate great tasting gums that deliver actives into the bloodstream faster than traditional gums used by others in the industry

.

[Anthony_Loera]

Interesting, let me contact them for a quote.

thanks
Anthony

[Anthony_Loera]

I got Tommy's voice mail over at Nutravail, so this may take a bit since it's Thursday... I'll probably have a quote sometime next week.

thanks again asnufu

A

[asnufu]

Great - I hope you'll keep us updated; a superior gum formulation could be a real boon, I think, both to the hard-core resv community here at imminst, but also by making the entire concept more appealing to people who can't see themselves "popping pills" ...