I knew about the study in which Sinclair's team showed that resveratrol added to a high fat diet in mice made up for the negative impacts of that high fat diet.
I didn't know that there was another study of mice given a high fat diet but even more resveratrol in which the mice stayed slender.
From this article:
The journal article is: Cell. 2006 Dec 15;127(6):1109-22. Epub 2006 Nov 16. Abstract:Sinclair's paper came out within days of a study in Cell from the lab of Johan Auwerx of the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France. �Auwerx's team, which was partially funded by Sirtris �(Auwerx is on the company's scientific advisory board), had given mice even higher doses of resveratrol--400 milligrams per kilogram. These mice stayed slender and strong on a high-fat diet, with the energy-charged muscles and reduced heart rate of athletes. The number of mitochondria in their cells increased, which improved the cells' energy output.
StephenDiminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1alpha acetylation and an increase in PGC-1alpha activity. This mechanism is consistent with RSV being a known activator of the protein deacetylase, SIRT1, and by the lack of effect of RSV in SIRT1(-/-) MEFs. Importantly, RSV treatment protected mice against diet-induced-obesity and insulin resistance. These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis.
Edited by stephen_b, 15 August 2007 - 01:25 PM.
