J' class='bbc_url' title='External link' rel='nofollow external'>http://pmid.us/full:20191055']J Korean Med Sci. 2010 Mar;25(3):492-5. Epub 2010 Feb 17.
Aloe-induced toxic hepatitis.
Yang HN, Kim DJ, Kim YM, Kim BH, Sohn KM, Choi MJ, Choi YH.
Source
Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Korea.
Abstract
Aloe has been widely used in phytomedicine. Phytomedicine describes aloe as a herb which has anti-inflammatory, anti-proliferative, anti-aging effects. In recent years several cases of aloe-induced hepatotoxicity were reported. But its pharmacokinetics and toxicity are poorly described in the literature. Here we report three cases with aloe-induced toxic hepatitis. A 57-yr-old woman, a 62-yr-old woman and a 55-yr-old woman were admitted to the hospital for acute hepatitis. They had taken aloe preparation for months. Their clinical manifestation, laboratory findings and histologic findings met diagnostic criteria (RUCAM scale) of toxic hepatitis. Upon discontinuation of the oral aloe preparations, liver enzymes returned to normal level. Aloe should be considered as a causative agent in hepatotoxicity.
PMID: 20191055
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Ann' class='bbc_url' title='External link' rel='nofollow external'>http://pmid.us/17726067']Ann Pharmacother. 2007 Oct;41(10):1740-3. Epub 2007 Aug 28.
Oral aloe vera-induced hepatitis.
Bottenberg MM, Wall GC, Harvey RL, Habib S.
Source
Veterans Affairs Medical Center, Des Moines, IA, USA. michelle.bottenberg@drake.edu
Abstract
OBJECTIVE: To report a case of possible oral aloe vera-induced hepatitis.
CASE SUMMARY: A 73-year-old female was admitted to the hospital for acute hepatitis. Extensive laboratory testing did not reveal the cause of the patient's disease. She was asked multiple times whether she was taking any home medications, which she initially denied. It was only after an extensive medication history done by a clinical pharmacist that the patient admitted to using oral aloe vera capsules for constipation. Upon discontinuation of the oral aloe vera, liver markers of hepatotoxicity returned to normal levels.
DISCUSSION: Herbal medications pose an increasing problem in patient safety, as the different types of these products and the number of patients who use them continue to grow. In the US, these products are not subject to the same regulatory scrutiny as prescription medications; thus, safety information can be difficult to obtain. In particular, hepatic toxicity due to herbal agents is poorly described in the medical literature. Aloe vera, often used topically for minor burns, can also be used orally as a laxative or an "anti-aging" agent. According to the Naranjo probability scale, the hepatotoxicity in this case was possibly related to ingestion of oral aloe vera. Additionally, using the Roussel Uclaf Causality Assessment Method for determining drug hepatotoxicity, the patient's symptoms were scored as probably caused by oral aloe vera. The more conservative designation was used in our report.
CONCLUSIONS: With the widespread use of oral aloe vera and other herbal products, clinicians faced with a case of acute hepatitis that is not readily diagnosed should question patients about herbal use.
PMID: 17726067
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Edited by ta5, 26 September 2012 - 01:39 AM.