6 replies to this topic

[goku]

Ok, money doesn't even have to come into the argument here, so forget price -- I just want to know simply what is the best res sup available?

Would love for suppliers and consumers to both make their argument for which they feel is best.

Frankly I would just like to know that the res I'm taking isn't already oxidized before I ever take it. Not very confident that's the case though, even though I'm taking longinex, which I thought might be best -- but honestly I have no idea.

I really have no idea how anyone can be sure of any company's claims. Even a COA and independent 3rd party testing doesn't convince me of much -- I've seen how easy it is to hide, disguise or fake these things.

[Anthony_Loera]

Goku,

<Edited>

I am editing this post Goku, as I think some info is needed.

Your best bet is a COA from a reputable company, if expense is no object... consider searching through the university papers and find the source of resveratrol that is used for the particular study. The reason I say this, is because the consultant we have still believes that certain amounts may be better suited for different issues.

As you don't care about price, then you open yourself up to products that are completely, unequivocally, irreproachable for their quality and science. I suggest calling up Pfizer directly, Orchid, or many of the folks who are listed on the actual research papers... for a sample or product of your choice.

Make no mistake about it, they will be a bit expensive, but because they are used in actual research and are listed as a supplier for the particular ailment in the paper you maybe interested about, it will be your best bet.

Thanks
Anthony Loera

Edited by Anthony_Loera, 22 August 2007 - 07:32 PM.

[Anthony_Loera]

See above, I edited my original post.

[tintinet]

Yabut...

Individuals not associated with research projects may find pharmaceutical corporations and chemical supply companies reluctant to dole out synthetic trans-resveratrol for personal use.

[Anthony_Loera]

If money were truly no object ...

I still don't see this as a problem...
Hire a rep, do some legit research, and get the benefits, plus be published!

great stuff
A

[bionutra]

It is next to impossible to get synthetic 99% trans-resverarol from companies like Pfizer or Orchid for daily consumption. The health benefits are more associated with 50% extract rather than 98% t-resveratrol.
The research studies mentions that the health benefits of resveratrol would be due to the total anti-oxidant pool available rather than pure trans-resveratrol

Bioavailability of trans-resveratrol from red wine in humans
Paola Vitaglione 1, Stefano Sforza 2, Gianni Galaverna 2, Cristiana Ghidini 3, Nicola Caporaso 1, Pier Paolo Vescovi 3, Vincenzo Fogliano *, Rosangela Marchelli 2
1Dipartimento di Scienza degli Alimenti, Università degli Studi di Napoli Federico II, Portici (NA), Italy. Fax: +39-081-7762-580
2Dipartimento di Chimica Organica ed Industriale, Università di Parma, Parma, Italy
3Dipartimento di Medicina Interna e Scienze Biomediche, Centro di Alcologia, Parma, Italy

email: Vincenzo Fogliano (fogliano@unina.it)

*Correspondence to Vincenzo Fogliano, 1Dipartimento di Scienza degli Alimenti, Università degli Studi di Napoli Federico II, Portici (NA), Italy. Fax: +39-081-7762-580


Keywords
Glucuronides • Liquid chromatography-mass spectrometry • Resveratrol • Wine


Abstract
Many in vitro studies demonstrated significant biological effects of trans-resveratrol. Thus, understanding the rate of intestinal absorption and metabolization in vivo of trans-resveratrol is the prerequisite to evaluate its potential health impact. Bioavailability studies mainly in animals or in humans using the pure compound at very high doses were performed. In this work, trans-resveratrol bioavailability from a moderate consumption of red wine in 25 healthy humans has been studied by three different experiments. The wine ingestion was associated to three different dietary approaches: fasting, a standard meal, a meal with high and low amount of lipids. Trans-resveratrol 3- and 4-glucuronides were synthesized, purified, and characterized as pure standards. Bioavailability data were obtained by measuring the concentration of free, 3-glucuronide and 4-glucuronide trans-resveratrol by high-performance liquid chromatography (HPLC), both with ultraviolet (UV) and mass spectrometry (MS) detection, in serum samples taken at different times after red wine administration. Free trans-resveratrol was found, in trace amounts, only in some serum samples collected 30 min after red wine ingestion while after longer times resveratrol glucuronides predominated. Trans-resveratrol bioavailability was shown to be independent from the meal or its lipid content. The finding in human serum of trans-resveratrol glucuronides, rather than the free form of the compound, with a high interindividual variability, raises some doubts about the health effects of dietary resveratrol consumption and suggests that the benefits associated to red wine consumption could be probably due to the whole antioxidant pool present in red wine.

[dannov]

Bionutra,

A number of issues with what you posted.

#1 - It is not true that Res50 is better than Res98. Trans-Rev is the ONLY beneficial part of Res50, and that is 50% of the combination. The rest is Emodin (a laxative), Cis-Resveratrol (worthless), and other misc. ingredients. The antioxidant pool present in Red wine has abolutely nothing to do with Res50. Those are just other things found in the fermented grapes along WITH Resveratrol.

#2 - Red Wine is a horrible supply of Trans-Res. You would need about 100 glasses a day to get the full benefit of trans-res, and then I think the side-effects of all that alcohol would greatly exceed the benefits of the trans-res.

#3 - Note what they said about bioavailability in this study:

"Free trans-resveratrol was found, in trace amounts, only in some serum samples collected 30 min after red wine ingestion while after longer times resveratrol glucuronides predominated."

"The finding in human serum of trans-resveratrol glucuronides, rather than the free form of the compound..."

As I've mentioned before, there are two enzymes that turn trans-res into a waste product. These enzymes are Sulfatase and Glucoronidase. This is exactly why Pat Arnold in his Giant Resveratrol product uses Quercetin and Piperine. These respective chemicals both work to inhibit the two enzymes that turn Resveratrol into, basically, worthlessness. As long as those enzymes are inhibited (as they have been PROVEN in pubmed.com peer-reviewed articles to inhibit the same enzymes that destroy Res), then results attained will be far more substantial.

The second quote is referring to the uninhibited glucoronidase enzymes that bonded with the trans-res, thus rending it fairly worthless. If you want to keep it free-form, you NEED to bind those enzymes with chemicals that preferentially use up those enzymes.

If you go to vitaminshoppe.com and pick up Quercetin/Piperine (pretty cheap actually) to supplement with your Res, your results should be considerably greater.