4 replies to this topic

[bcs4]

Interesting site.

I've been on a low dose of resveratrol for almost a year now, was afraid of increasing because I'm on a statin. I had seen something about the possibility of resveratrol acting similar to grapefruit juice and thus making it likewise dangerous in combination.

Anyone have any additional info related to safe amounts of resveratrol when taking with statins? Is it actually a concern?

[tintinet]

Looks good, if yer a rat!



1: J Mol Cell Cardiol. 2007 Mar;42(3):508-16. Epub 2006 Dec 26.Click here to read Click here to read Links
Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat.
Penumathsa SV, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, Pant R, Menon VP, Otani H, Maulik N.

Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1110, USA.

Hypercholesterolemia (HC) is a common health problem that significantly increases risk of cardiovascular disease. Both statin (S) and resveratrol ® demonstrated cardioprotection through nitric oxide-dependent mechanism. Therefore, the present study was undertaken to determine whether combination therapy with statin and resveratrol is more cardioprotective than individual treatment groups in ischemic rat heart model. The rats were fed with 2% high cholesterol diet and after 8 weeks of high cholesterol diet the animals were treated with statin (1 mg/kg bw/day) and resveratrol (20 mg/kg bw/day) for 2 weeks. The rats were assigned to: (1) Control ©, (2) HC, (3) HCR, (4) HCS and (5) HCRS. The hearts, subjected to 30-min global ischemia followed by 120-min reperfusion were used as experimental model. The left ventricular functional recovery (+dp/dt(max)) was found to be significantly better in the HCRS (1926+/-43), HCR (1556+/-65) and HCS (1635+/-40) compared to HC group (1127+/-16). The infarct sizes in the HCRS, HCS and HCR groups were 37+/-3.6, 43+/-3.3 and 44+/-4.2 respectively compared to 53+/-4.6 in HC. The lipid level was found to be decreased in all the treatment groups when compared to HC more significantly in HCS and HCRS groups when compared to HCR. Increased phosphorylation of Akt and eNOS was also observed in all the treatment groups resulting in decreased extent of cardiomyocyte apoptosis but the extent of reduction in apoptosis was more significant in HCRS group compared to all other groups. In vivo rat myocardial infarction (MI) model subjected to 1 week of permanent left descending coronary artery (LAD) occlusion documented increased capillary density in HCR and HCRS treated group when compared to HCS treatment group. We also documented increased beta-catenin translocation and increased VEGF mRNA expression in all treatment groups. Thus, we conclude that the acute as well as chronic protection afforded by combination treatment with statin and resveratrol may be due to pro-angiogenic, anti-hyperlipidemic and anti-apoptotic effects and long-term effects may be caused by increased neo-vascularization of the MI zone leading to less ventricular remodeling.

PMID: 17188708 [PubMed - in process]

[bcs4]

Interesting, but I was more interested in finding out if anyone had seen if resveratrol might cause more absorption of statin drugs (similar to grapefruit juice) and the resulting kidney and muscle neuropathy.

Thanks

[niner]

I've been on a low dose of resveratrol for almost a year now, was afraid of increasing because I'm on a statin. I had seen something about the possibility of resveratrol acting similar to grapefruit juice and thus making it likewise dangerous in combination.

Anyone have any additional info related to safe amounts of resveratrol when taking with statins? Is it actually a concern?

Grapefruit juice (as well as some other fruits) are a problem because they inhibit CYP3A4, predominantly in the gut. This inhibition is covalent, which is fairly unusual in a P450 inhibitor. That means that when the enzyme is hit, it is taken out for good, and is effectively dead until it is replaced, which in the case of the gut P450s is only a few days. Most P450 inhibitors are non-covalent, meaning that when the concentration in plasma drops significantly below the IC50 for the inhibition, the enzyme works again, so timescales for reactivation of the enzyme are much shorter. To address your question (finally...), I'm not aware of any significant inhibition of drug metabolizing enzymes by resveratrol. To know for certain that there was no effect on statins, I suppose you would want to get your statin level checked. While I don't take statins myself, I do use several other pharmaceuticals in conjunction with a moderately high (350mg/d) resveratrol dose, and have not had any problems.

[rwoodin]

I take 1-2gm a day of 99% resveratrol. Have been on 20mg a day lipitor for a few years. Not aware of any problems associated with it. My physician is aware of all supplements I take. Last 2 cholesterol panels, done over past year were good. I should probably get checked again soon as I have upped my dosage of resveratrol over past 6 months...