1 reply to this topic

[skuldugary]

I came across an interesting article while researching treatment for my dog, who had a hemangiosarcoma (a malignant cancerous tumor) on her spleen. the spleen was removed, but the prognosis is grim. The mainstream veterinary advice is to either put the dog down immediately, or if you did the surgery, wait for the next acute issue and put the dog down then. Life expectancy is 2-6 months.

Passively waiting for my dog to die did not appeal to me, so i started looking around for alternative ideas, and found this article

http://www.drplechne...nthecortex.html

This article hypothesizes that the cause for many dog and cat diseases is genetic flaws due to inbreeding, and the particular problem is with the adrenal gland and the immuno-endocrine system. The treatment is very low dosages of cortisone. Apparently some work has been done with humans and the same issues, and the article wonders if this treatment may be useful for humans with HIV or cancer. I have done quite a bit of research on Cancer, anyway (due to my wife having breast cancer (and surviving :-) and i never heard of this..

The vet (who I talked to and who seems really on the ball, I was impressed) has had animals with the same cancer as my dog survive for years by following his protocol. He has a book out ("Pets At Risk") which goes into detail on the research and protocol for animals.

With the help of a wonderful holistic vet in my area I am treating my dog with this protocol (which is also given here: http://www.drplechne.../protocol.html), so I'll soon have some first hand evidence about how effective this is, but I am wondering if anyone on this forum has heard of this possible interaction, and what they think of the article.

Thoughts? Anyone heard of anything like this with humans? Does this seem to be a reasonable hypothesis?

thanks,

Doug

[neogenic]

Wikipedia:
Cortisol and adrenaline are the main hormones released by the body as a reaction to stress. They elevate blood pressure and prepare the body for a fight or flight response.

Cortisone is sometimes used as a drug to treat a variety of ailments. It can be administered intravenously or cutaneously.

One of cortisone's effects on the body, and a potentially harmful side effect when administered clinically, is the suppression of the immune system. This could be the explanation for the apparent correlation between high stress and sickness. The suppression of the immune system may be important in the treatment of inflammatory conditions such as severe IgE-mediated allergies.

Cortisone is less important than a similar steroid cortisol. Cortisol is responsible for 95% of the effects of the glucocorticosteroids while cortisone is about 4 or 5%. Corticosterone is even less important.

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So, there is an effect of suppression of the immune system. Which in HIV and like diseases would be advantageous, I would assume. As, it states, it's a potentially harmful side effect as well. Clearly, you'd be more susceptible to infections, viruses, and other baddies. So possibly using a low dose, you can run a balance and keep things in check that want to run unabated and casue havoc, much like Cancer and HIV-1. I haven't researched it out, but that's a starting point. Much of HIV/AIDS is the huge risk of simple viruses or bacterial infections, due to innumerous drug cocktails that do shut down the immune system. They can die from a simple cold...depending on how in check they are. Having LBM and not being cachectic can help in this regard and the AAS (steroids) play a role in that.

I don't think there's any big breakthrough here and the drugs we use with humans in this regard are much, much, much more expensive. This seems like a simple way to work with dogs or animals in relatively low-cost, not better...and certainly they're not getting monitor with labs nearly as much as these more potent drugs like with Cancer/HIV either.

It all adds up well on a quick lookover.