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Effect of multivitamin and multimineral supplement


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#1 doug123

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Posted 10 October 2007 - 01:47 AM


Let me please introduce: Nutrition Journal. Here is data provided in the "about" section of their journal:

About Nutrition Journal

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What is Nutrition Journal?


Nutrition Journal is an open access, peer-reviewed, online journal that considers manuscripts within the field of human nutrition. Animal studies are not published.

Nutrition Journal aims to encourage scientists and physicians of all fields to publish results that challenge current models, tenets or dogmas. The journal invites scientists and physicians to submit work that illustrates how commonly used methods and techniques are unsuitable for studying a particular phenomenon. Nutrition Journal strongly promotes and invites the publication of clinical trials that fall short of demonstrating an improvement over current treatments. The aim of the journal is to provide scientists and physicians with responsible and balanced information in order to improve experimental designs and clinical decisions.

With the advent of the Internet, has dawned a new way to exchange information and to publish biomedical journals. BioMed Central has been a pioneer in online publishing with Nutrition Journal being one of its many journals. Publication in Nutrition Journal offers many advantages over traditional paper publications; the journal offers free access to its articles; high quality and rapid peer-review; immediate publication; and most importantly, universal access to its content from virtually any place in the world.

Content overview


Nutrition Journal considers the following types of articles:

o Research - reports of data from original research.
o Case reports - reports of clinical cases that can be educational, describe a diagnostic or therapeutic dilemma, suggest an association, or present an important adverse reaction.
o Reviews - comprehensive, authoritative descriptions of any subject within the scope of Nutrition Journal; these articles are usually written by opinion leaders who have been invited by the board.

Peer review policies


o Each manuscript submitted to Nutrition Journal will be assigned to one or two external reviewers for peer-review, which is normally completed in 2 to 8 weeks. In deciding whether to accept or reject a manuscript, a reviewer asks him/herself whether the scientific community is better served by publishing or not publishing the manuscript. In the absence of compelling reasons to reject, Nutrition Journal advises that reviewers recommend acceptance, as ultimately the quality of an article will be judged by the scientific community after its publication. A maximum of 2 revisions can be made per manuscript.
o To promote dialogue in the field, Nutrition Journal invites authors and readers to post comments on published articles.
Edited by Nehme Gebrayel, Nutrition Journal is supported by an international Editorial Board.

To review the rest of their about page, please click here


*Unofficial* Impact factor 2.02:

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Here is the abstract:

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Research
Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial

Geraldine McNeill1 , Alison Avenell2 , Marion K Campbell2 , Jonathan A Cook2 , Philip C Hannaford3 , Mary M Kilonzo4 , Anne C Milne2 , Craig R Ramsay2 , D Gwyn Seymour5 , Audrey I Stephen2  and Luke D Vale2,4

1Department of Environmental and Occupational Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
2Health Services Research Unit, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
3Department of General Practice and Primary Care, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
4Health Economics Research Unit, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
5Department of Medicine for the Elderly, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK


author email  corresponding author email

Nutrition Journal 2007, 6:10doi:10.1186/1475-2891-6-10

The electronic version of this article is the complete one and can be found online at: http://www.nutrition.../content/6/1/10

Received: 20 November 2006
Accepted: 2 May 2007
Published: 2 May 2007

© 2007 McNeill et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommo...licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract
Background
Observational studies have frequently reported an association between cognitive function and nutrition in later life but randomised trials of B vitamins and antioxidant supplements have mostly found no beneficial effect. We examined the effect of daily supplementation with 11 vitamins and 5 minerals on cognitive function in older adults to assess the possibility that this could help to prevent cognitive decline.


Methods
The study was carried out as part of a randomised double blind placebo controlled trial of micronutrient supplementation based in six primary care health centres in North East Scotland. 910 men and women aged 65 years and over living in the community were recruited and randomised: 456 to active treatment and 454 to placebo. The active treatment consisted of a single tablet containing eleven vitamins and five minerals in amounts ranging from 50–210 % of the UK Reference Nutrient Intake or matching placebo tablet taken daily for 12 months. Digit span forward and verbal fluency tests, which assess immediate memory and executive functioning respectively, were conducted at the start and end of the intervention period. Risk of micronutrient deficiency at baseline was assessed by a simple risk questionnaire.

Results
For digit span forward there was no evidence of an effect of supplements in all participants or in sub-groups defined by age or risk of deficiency. For verbal fluency there was no evidence of a beneficial effect in the whole study population but there was weak evidence for a beneficial effect of supplementation in the two pre-specified subgroups: in those aged 75 years and over (n 290; mean difference between supplemented and placebo groups 2.8 (95% CI -0.6, 6.2) units) and in those at increased risk of micronutrient deficiency assessed by the risk questionnaire (n 260; mean difference between supplemented and placebo groups 2.5 (95% CI -1.0, 6.1) units).

Conclusion

The results provide no evidence for a beneficial effect of daily multivitamin and multimineral supplements on these domains of cognitive function in community-living people over 65 years. However, the possibility of beneficial effects in older people and those at greater risk of nutritional deficiency deserves further attention.


To view the entire publication, please click here

Other recent publications on multivitamins/minerals are:

o JAMA: Vitamin E, A, beta-caro increases mortality

o Archives of Internal Medicine: Vitamins C and E and Beta Carotene: No benefit, in the Secondary Prevention of Cardiovascular Events in Women

o Antioxidant Supplementation Increases the Risk of Skin Cancers in Women but Not in Men

o New...Vitamin link with cancer, :(

Thoughts, comments, suggestions?

Take care.




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