4 replies to this topic

[tarbtl]

Hey guys,

I occasionally take Dexedrine for inattentive ADD and it helps immensly, however even with sparce usage I have developped tolerance fairly quickly. The only thing I have found to reverse this tolerance is DXM (found this on the bluelight forum).

I'm taking the regular cough-suppresive dosage in the form of the Benylin syrup. I've heard reports of long-term brain damage from DXM. At this extremely low-dose, should I be concerned? I mean I'm already taking tons of nootropics and being "stupider" is the last thing in the world I'd want.

Thanks.

[rabagley]

It's not clear that you can get enough DXM through your digestive tract to cause Olney's Lesions. They had to inject rats with it to get enough in their systems. Most of the other known effects from DXM are related to frequent recreational usage, which is an amount 10-40x what you're taking per dose (200-400mg instead of 10-20mg).

But if you're still worried, ask the doctor who prescribed Dexedrine for you. (S)he'll know as much as we do about Dexedrine and DXM and (s)he'll hopefully know you even better.

[graatch]

Check your body temp.

[graatch]

>But if you're still worried, ask the doctor who prescribed Dexedrine for you. (S)he'll know as much as we do about Dexedrine and DXM and (s)he'll hopefully know you even better.

Are you joking? If I had ever told any of the doctors that gave me psychostimulants I was using cough medicine to offset tolerance, I would lose both a psychostimulant and a doctor.

The idea of NMDA antagonism possibly combating one mechanism of tolerance is probably not something they focus on in medical school, so much, so no reason the doctor would know more than us unless they happened to be interested.

[fast turtle]

Not toxic, at all. In the studies with rats they fed them oral amounts that were absurdly high (hundreds of times what you're talking about) and while some rats died because of the behavioural effects, autopsy revealed no actual perceivable neurotoxicity. In fact, NMDA antagonists have been investigated for the longest time as neuroprotectives.