4 replies to this topic

[MP11]

This is reposted from another forum, I wanted to see if anyone had opinions or thoughts about it?:

Study Showing The Negative Effects Of Psychstimulants On The Action Of Nootropics
I recently came across this study and would like to share it in order to get some feeback from those who use a signifigant amount of stimulants,in conjunction with nootropics,on a chronic basis.I've had moteworthy good results on my mind/mentalook looks and so on with nootropics and the only qualm I have with notropics in general is that psychostimulanst may very well negate a signifigant amount of the benefits of the racetams and other such drugs.Considering I go heavy handed with stimulant usage on a chronic basis,I could be realizing more but it is not altogether surprising that when one puts themselves into a near manic,overexitable state through the use of potent CNS stimulants that having the requisite will to put solely into a deeper/introspective line of thinking is somewhat impaired.

Acta Physiol Pharmacol Bulg. 1991;17(4):17-26. Related Articles, Links

Modulation of the effects on learning and memory of nootropic drugs and central stimulants when applied together.

Petkov VD, Konstantinova E, Petkov VV, Lazarova M, Petkova B.

Institute of Physiology, Bulgarian Academy of Sciences, Sofia.

In experiments on rats using passive avoidance with punishment reinforcement (step-through) and two-way active avoidance with punishment reinforcement (shuttle-box), we examined the effects on acquisition and retention of different combinations of the nootropic drugs meclofenoxate (Mf), citicholine (CCh), piracetam (Pc), the structural analogues of aniracetam p-P and p-F, standardized extract from ginseng roots (PG) and the psychostimulants caffeine (Caf) and amphetamine (Amph). Favorable effects (more pronounced improvement of learning and/or memory as compared to that caused by the drugs when given alone) were in some cases obtained by the combination Mf+Caf, Pc+Caf, CCh+Caf, p-F+Caf, Mf+CCh, as well as by the combination Mf+PG applied to rats with electroconvulsive shock-induced amnesia. However, in some cases the combined administration of two drugs with favorable effects on memory did not led to summation or potentiation but rather to disappearance of these effects. This was observed under certain experimental conditions with some combinations of Caf and CCh, Mf, Pc and p-P and with some combinations of Amph and Mf. Based on our earlier results and data in the literature, we present some considerations about the role of the neurotransmitter mechanisms of action of the drugs tested as neurochemical correlates of their effects on memory. It is suggested that the unfavorable results obtained in some cases with combinations of nootropics and psychostimulants are due to the possible disturbance of selective acquisition by the psychostimulant drug.

Edited by mp11, 30 November 2007 - 06:28 PM.

[Rags847]

Wonder about the effects of combining Modafinil with nootropics. If "possible disturbance of selective acquisition by the psychostimulant drug" occurs.
Actually, the title of your thread should be Study Showing The Negative Effects Of Psychstimulants On The Action Of Nootropics.

Edited by Rags847, 30 November 2007 - 06:03 PM.

[MP11]

Wonder about the effects of combining Modafinil with nootropics. If "possible disturbance of selective acquisition by the psychostimulant drug" occurs.
Actually, the title of your thread should be Study Showing The Negative Effects Of Psychstimulants On The Action Of Nootropics.

Good idea, that's much more descriptive.

[Rags847]

Thanks for posting the above study. Quite interesting.
Would love to see studies on the effects of Modafinil on nootropics.
Modafinil acts on the brain in such a targeted and superior way than other psychostimulants that nothing from the above study could be inferred in its case.

Edited by Rags847, 30 November 2007 - 06:59 PM.

[MP11]

A little more info about modafinil as well as some other substances that people here may use. This study touches on the methods of neurotransmitter action- something to keep in mind when combining noots along with other substances:

What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.
Boutrel B, Koob GF.

Department of Neuropharmacology, The Scripps Research Institute. Benjamin.Boutrel@hospvd.ch

Numerous studies dissecting the basic mechanisms that control sleep regulation have led to considerable improvement in our knowledge of sleep disorders. It is now well accepted that transitions between sleep and wakefulness are regulated by complex neurobiologic mechanisms, which, ultimately, can be delineated as oscillations between two opponent processes, one promoting sleep and the other promoting wakefulness. The role of several neurotransmitter or neuromodulator systems, including noradrenergic, serotonergic, cholinergic, adenosinergic, and histaminergic systems and, more recently, the hypocretin/orexin and dopamine systems, has been clearly established. Amphetamine-like stimulants are known to increase wakefulness by blocking dopamine reuptake, by stimulating dopamine release, or by both mechanisms. Modafinil may increase wakefulness through activation of noradrenergic and dopaminergic systems, possibly through interaction with the hypocretin/orexin system. Caffeine inhibits adenosinergic receptors, which in turn can produce activation via interaction with GABAergic and dopaminergic neurotransmission. Nicotine enhances acetylcholine neurotransmission in the basal forebrain and dopamine release. Understanding the exact role of the hypocretin/orexin and dopamine systems in the physiology and pharmacology of sleep-wake regulation may reveal new insights into current and future wakefulness-promoting drugs.

PMID: 15532213 [PubMed - indexed for MEDLINE]

Edited by mp11, 22 December 2007 - 07:53 PM.