LONGECITY

...I wonder what they mean by "local administration"? Eardrops good, hole drilled in skull... bad.

From: http://www.aurismedi...m_101.php?lg=en

AM-101 is administered by intratympanic injection, a slightly invasive and safe procedure that has been known and practiced by ENT doctors for several decades. For the injection, the eardrum is first locally anaesthetized, then slightly perforated with a fine needle through which the drug is administered into the middle ear. During the procedure and for 30 minutes thereafter, patients are lying with their treated ear up. This shall allow for maximum contact of the drug product with the round window membrane - it is throgh this very small membrane that AM-101 then diffuses into the inner ear and reaches its target. After the resting period, patients get up and can go home.

This source did not seem to indicate how often this procedure was required for continuous tinnitus suppression.

Some early results

"In terms of efficacy, the clinical trial provided first indications for the potential efficacy of AM-101 in the treatment of inner ear tinnitus. The clinical data suggest that AM-101 has a positive effect on the perceived loudness of tinnitus as well as on its maskability; in addition, a positive trend was observed in the overall tinnitus handicap as measured by the TBF-12 questionnaire. Further details of the clinical trial and its outcomes shall be published later in a scientific journal."

NMDA antagonists make my tinnitus worse.