12 replies to this topic

[maestro949]

From the scientific gem Esquire, Andy Dillan, who works with Cynthia Kenyon hints that the Salk institute is studying a novel compound that affects the rate of aging. Hopefully it's not just resveratrol or a derivative. We should keep an eye out for the paper

One of the papers Dillin has yet to publish has to do with a compound -- a drug -- found by his lab that also makes the worms resistant to Alzheimer's. His lab did not set out to find a drug; it intended to find a research tool that would allow him to investigate the insulin-signaling and PHA-4 pathways without having to mutate any genes, which can't return to normal. He had one of the research associates working in his lab test a series of compounds found in nature, and was surprised to find one that prevents the Alzheimer's symptoms more effectively than the mutated genes did. The compound also seemed to extend the life spans of the worms, although Dillin doesn't yet know exactly how it works. Once he informed the Salk Institute what his lab had found, Salk improved upon the compound and changed its chemical structure so that it is, in effect, a novel compound. It is not found in nature anymore. It is a proprietary property.

Esquire - No One Wants to Live Forever

Andy Dillan's publications

Edited by maestro949, 13 December 2007 - 01:14 PM.

[Luna]

From the scientific gem Esquire, Andy Dillan, who works with Cynthia Kenyon hints that the Salk institute is studying a novel compound that affects the rate of aging. Hopefully it's not just resveratrol or a derivative. We should keep an eye out for the paper

One of the papers Dillin has yet to publish has to do with a compound -- a drug -- found by his lab that also makes the worms resistant to Alzheimer's. His lab did not set out to find a drug; it intended to find a research tool that would allow him to investigate the insulin-signaling and PHA-4 pathways without having to mutate any genes, which can't return to normal. He had one of the research associates working in his lab test a series of compounds found in nature, and was surprised to find one that prevents the Alzheimer's symptoms more effectively than the mutated genes did. The compound also seemed to extend the life spans of the worms, although Dillin doesn't yet know exactly how it works. Once he informed the Salk Institute what his lab had found, Salk improved upon the compound and changed its chemical structure so that it is, in effect, a novel compound. It is not found in nature anymore. It is a proprietary property.

Esquire - No One Wants to Live Forever

Andy Dillan's publications

What do they mean no wants to live forever?
and what do they mean by jsut staying young?! grr

[maestro949]

What do they mean no wants to live forever?

It means just that - that everyone is looking forward to die. Even you. You just don't know it yet because you're a wackjob. I am too but don't worry, there might be a cure for us circus freaks.

[Luna]

What do they mean no wants to live forever?

It means just that - that everyone is looking forward to die. Even you. You just don't know it yet because you're a wackjob. I am too but don't worry, there might be a cure for us circus freaks.

Meh! me not die. me live forever.
Humans = suicidal.

[forever freedom]

Wow great news. I hope that it ends up in something useful, instead of just fading and being forgotten by everyone.

[caston]

"The essence of youthfulness," according to Andy Dillin, "is accuracy and precision of protein folding."

[luv2increase]

Hopefully it's not just resveratrol or a derivative. We should keep an eye out for the paper

If it is a derivative of resveratrol, which I suspect it will be, so be it. As long as it does what it is claimed to do. I see this as progress. I highly doubt it is just plain ole' resveratrol.

[JRMKYLE]

This is very, very hopeful news from the Salk Inst.

I must say that I was disgusted by the way the writer had to take several paragraphs to bow to the pro-death majority he perceived to be his readers.

How stupid anyone would have to be to not want to die. Certainly anyone with any common sense should want to die as soon as possible – if we accept the position of the author of this article.

[caston]

Hey guys my mind was racing today after I found an article on science daily about a protein that boosts the ability of macrophages to gang up on bad bacteria and one of the thoughts I had reminded me of Andy Dillon and I thought I must see how he's going these days. He has a facebook page and I have sent him a friend request. He only has 50 or so friends so he may not accept people even if they say they are massive fans of his research but we'll see. Anyway he has links to a company called proteostasis (presumably his?) that seems to be working on some interesting biotech and although it looks like they want to keep it all fairly closed source they do have something very interesting on their science page.

http://www.proteosta...sis_network.php

Here is his public page on facebook. Maybe we can convince him to join our crowd

http://www.facebook....llin/1440121705

Edited by caston, 20 February 2010 - 03:56 PM.

[Mind]

Here is his public page on facebook. Maybe we can convince him to join our crowd

It wouldn't hurt to ask.

Also, thanks for reviving this old thread Caston! A lot of "breakthrough" news hits the internet nowadays but there isn't always good follow-up. It would be nice to have Mr. Dillin give everyone and update.

[caston]

You're welcome Mind.

He sounds like an ideal candidate for a TED Med talk.

I think he has done talks are various small scale yet highly respectable aging conferences.

http://www.nature.co...2009/index.html

He might be easier to find as Andrew G. Dillin e.g.:

http://www.keystones...FTOKEN=22114877

Edited by caston, 21 February 2010 - 12:22 AM.

[tunt01]

"The essence of youthfulness," according to Andy Dillin, "is accuracy and precision of protein folding."

consistent w/ the importance of autophagy and the unusual long lived naked mole rat.

[caston]

prophets: autophagy is also the most crucial part of the intracellular immune system.