8 replies to this topic

[maestro949]

Saw this via the GRG mailing list.

Amazon: Molecular Biology of Aging

Normal people are getting a PS3 or XBox 360 for xmas. I'm getting a 600 page book on death!

[brokenportal]

$200.00? Wow, but I want it too. I asked my family for gift cards to amazon.com for christmas. I couldnt find the summary of it at amazon, what does it go into, what angle is it taking?

Saw this via the GRG mailing list.

Amazon: Molecular Biology of Aging

Normal people are getting a PS3 or XBox 360 for xmas. I'm getting a 600 page book on death!

[maestro949]

$200.00? Wow, but I want it too. I asked my family for gift cards to amazon.com for christmas. I couldnt find the summary of it at amazon, what does it go into, what angle is it taking?

Indeed these books are expensive.

I saw this review at Eureka. The following is from the CSHL website:

Research into the causes of aging, and strategies to delay that process, have gained much ground and attention in recent years. This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer. Each chapter is written by one or more leaders in the field, and the book presents the current status of this exciting research area and provides an invaluable source of information in a single volume.


1. The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases
D.C. Wallace

2. Sirtuins: A Universal Link between NAD, Metabolism, and Aging
S.-i. Imai and L. P. Guarente

3. Calorie Restriction in Lower Organisms
S.L. Helfand, J.H. Bauer, and J.G. Wood

4. Evolutionary Theory in Aging Research
S.N. Austad and T.B.L. Kirkwood

5. An Overview of the Biology of Aging: A Human Perspective
G.M. Martin and C.E. Finch

6. p53, Cancer, and Longevity
L.A. Donehower and A.J. Levine

7. Aging Processes in Caenorhabditis elegans
H.A. Tissenbaum and T.E. Johnson

8. Cellular Senescence: A Link between Tumor Suppression and Organismal Aging?
J.M. Sedivy, U.M. Munoz-Najar, J.C. Jeyapalan, and J. Campisi

9. Genome-wide Views of Aging Gene Networks S.K. Kim

10. Aging in Mammalian Stem Cells and Other Self-renewing Compartments
D.J. Rossi and N.E. Sharpless

11. Yeast, A Feast: The Fruit Fly Drosophila as a Model Organism for Research into Aging
L. Partridge and J. Tower

12. DNA Repair and Aging
V.A. Bohr, D.M. Wilson, III, N.C. de Souza-Pinto, I. van der Pluijm, and J.H. Hoeijmakers

13. Extended Life Span in Mice with Reduction in the GH/IGF-1 Axis
J.J. Kopchick, A. Bartke, and D.E. Berryman

14. Alzheimer’s Disease: Genetics, Pathogenesis, Models, and Experimental Therapeutics
P.C. Wong, D.L. Price, L. Bertram, and R.E. Tanzi

15. How Does Calorie Restriction Increase the Longevity of Mammals?
R. Weindruch, R.J. Colman, V. Pérez, and A.G. Richardson

16. Determination of Aging Rate by Coordinated Resistance to Multiple Forms of Stress
G.J. Lithgow and R.A. Miller

17. Molecular Mechanisms of Aging: Insights from Budding Yeast
S.-J. Lin and D. Sinclair

18. Genetics of Exceptional Longevity
T.T. Perls and P. Sebastiani

19. Mammalian Metabolism in Aging
P. Puigserver and C.R. Kahn

20. Telomeres and Telomerase in Aging and Cancer
J.W. Shay and W.E. Wright

Edited by maestro949, 27 December 2007 - 03:43 PM.

[Shepard]

Oh, that looks quite wonderful.

I just snagged up a new version from one of the other Amazon sellers for $110 shipped. I'm happy considering the content and size.

[maestro949]

Oh, that looks quite wonderful.

I just snagged up a new version from one of the other Amazon sellers for $110 shipped. I'm happy considering the content and size.

I just received my copy. I've only thumbed through it for an hour but really like what I have read so far. Many of the references sited in each chapter are post 2000.

[Shepard]

I just received my copy. I've only thumbed through it for an hour but really like what I have read so far. Many of the references sited in each chapter are post 2000.

Awesome. It looks like mine is going to take a few days. I picked it up a little cheaper but the seller decided to use Media Mail.

[Athanasios]

I just snagged up a new version from one of the other Amazon sellers for $110 shipped. I'm happy considering the content and size.

Sure, push the price up for the rest of us.

[Shepard]

Mine came in on Saturday. Content looks impressive.

[maestro949]

Mine came in on Saturday. Content looks impressive.

Yes. It's good. This was my favorite chapter so far :

Stuart K. Kim - Genome-wide Views of Aging

Untangling the complex changes in gene expression as we age could be a huge boon to progress in longevity therapeutics. I'm starting to think that the $1000 genome is rather uninteresting compared to that of say a $1000 gene transcription profile reading. The latter would indicate exactly where you are in the aging process along with potential treatments whereas a genome screen would tell you where you're likely going to go based on a genetic profile.