I took hydergine for 80 days, during an 8 month cycle of piracetam, aniracetam, centrophenoxine, idebenone, salmon oil, ALCAR & ALA. Heard of beta blockers? Well this is an
alpha blocker. [edit]
Alpha blockers on wikipedia:
Adverse effects and interactions
By reducing α1-adrenergic activity of the blood vessels, these drugs may cause hypotension (low blood pressure) and interrupt the baroreflex response. In doing so, they may cause dizziness, lightheadedness, or fainting when rising from a lying or sitting posture (known as orthostatic hypotension or postural hypotension). For this reason, it is generally recommended that alpha blockers should be taken at bedtime. Additionally, the risk of first dose phenomenon may be reduced by starting at a low dose and titrating upwards as needed.
Because these medications may cause orthostatic hypotension, as well as hypotension in general, these agents may interact with other medications that increase risk for hypotension, such as other antihypertensives and vasodilators.
That is a pretty good evaluation of the side effects of hydergine. Standing up from sitting and lying in bed had to be done slow to prevent the lightheadedness. It increases glucose turnover in the brain, and you can feel it. However, the side effects on the blood pressure were just too much for me, because I already have very healthy lower blood pressure, and hydergine just pushed me down into the hypotension region. Lesson: monitor your blood pressure! Exercise while on this supplement was not easy. It most definitely is a smooth muscle relaxer, and as such, food just 'sat' on my stomach if I ate after taking it. Taking it at bedtime was the only tolerable way for me to avoid that problem.
It has some merits; the synergy with piracetam is no joke. After taking piracetam for some time, I would get whole-field-of-vision white flashes. They were ultimately the reason I stopped taking 'racetams, but I found that they were far less frequent when taking hydergine in conjunction. It should be noted I already had a history of ocular migraines, which caused half hour visual aberrations without the pain commonly associated with migraines. Whether the white flashes were connected to the piracetam or the ocular migraines I do not know, but cessation of the piracetam always eliminated the white flashes, and there were no visual effects from hydergine alone. The stress abating properties of hydergine were obvious. I could never lose my cool or be anxious while on hydergine.
Anyways, I hope that helped, and remember, your mileage may vary.