10 replies to this topic

[dachshund]

http://www.physorg.c...s119276583.html

[health_nutty]

http://www.physorg.c...s119276583.html

The article has been retracted.

[edward]

http://biosingularit...imple-organism/

This link is still good, though its rather ominous that one source retracted the article.

[edward]

Study published in Cell (Issue 130, pages 247-258, 2007)

Contact: Carl Marziali
marziali@usc.edu
213-219-6347
University of Southern CaliforniaSource:Eurekalert

Anyone who has a subscription to Cell or has online resources might want to post this study if they can access it.

[Mind]

This must be the "Longo" that the article talks about.

Here is another article quoting him back in November.

I think I should invite him for a Sunday Night Chat.

[edward]

This must be the "Longo" that the article talks about.

Here is another article quoting him back in November.

I think I should invite him for a Sunday Night Chat.

That would be wonderful. Being a professor also I think he might accept.

Edit: or maybe not ...

"Dr Longo said parallel experiments on human liver cells appeared to replicate the effect, but refused to elaborate until the results have been published."

Edited by edward, 11 January 2008 - 10:27 PM.

[Hedgehog]

If you can link me to the absracts I don't mind getting them. It doesn't appear that they are out yet?

The study is scheduled to appear in the Jan. 25 issue of the journal PLOS Genetics. A companion study, showing that the same genetic changes in yeast reverse the course of an accelerated aging syndrome, appears in the Jan. 14 issue of the Journal of Cell Biology.

[edward]

If you can link me to the absracts I don't mind getting them. It doesn't appear that they are out yet?

The study is scheduled to appear in the Jan. 25 issue of the journal PLOS Genetics. A companion study, showing that the same genetic changes in yeast reverse the course of an accelerated aging syndrome, appears in the Jan. 14 issue of the Journal of Cell Biology.

I think you are right. I tried to find in on Cell's website, pubmed and others and no luck. We will have to wait a few days.

[Bram]

This is the article at the pages in Cell you mentioned:

1: Cell. 2007 Jul 27;130(2):247-58.

Type 5 adenylyl cyclase disruption increases longevity and protects against stress.
Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, Vatner SF.

Department of Cell Biology and Molecular Medicine and Cardiovascular Research Institute, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA.

Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are resistant to cardiac stress and have increased median lifespan of approximately 30%. AC5 KO mice are protected from reduced bone density and susceptibility to fractures of aging. Old AC5 KO mice are also protected from aging-induced cardiomyopathy, e.g., hypertrophy, apoptosis, fibrosis, and reduced cardiac function. Using a proteomic-based approach, we demonstrate a significant activation of the Raf/MEK/ERK signaling pathway and upregulation of cell protective molecules, including superoxide dismutase. Fibroblasts isolated from AC5 KO mice exhibited ERK-dependent resistance to oxidative stress. These results suggest that AC is a fundamentally important mechanism regulating lifespan and stress resistance.

PMID: 17662940 [PubMed - indexed for MEDLINE]

From the abstract it appears interesting, I haven't had time to read the whole thing yet though. Note that this is the study mentioned in the 8th paragraph of this article
http://biosingularit...imple-organism/
so *not* the new one that claims the 10-fold life span increase, mentioned in the 1st paragraph of that article. I'll put the whole publication in the resource sharing section anyway though.

[inawe]

In the work of the Longo group main energy generation in yeast cells is switched. From the mitochondrial CTA cycle to glycolysis in the cytosol, thus generating less ROS. Question is if that's even possible to do in knockout mice.

[Bram]

Looks like the paper's been published now, yay for open access

http://genetics.plos...al.pgen.0040013