27 replies to this topic

[exotiq]

I run a hedge/PE fund with a focus on buy-side trading of structured-products; exotic options, var-swaps and mortgage instruments; CDO, CDO^2, CDS, etc. I also invest (seed -> mezz financing) in biotech/pharma. As a disclaimer: I was an early PE-investor in S*rt*s.

My 14mo daughter has a congenital metabolic disorder called Prader Willi Syndrome. We've tried various compunds to improve developmental-milestones; most of which are conventional-therapies (rhGH).

A S*rt*s employee recommended Resveratrol for my daughter. We began using synthetic micronized Resveratrol at 200mg daily bolus administration + 50mg EGCg. We immediately began to see results. Our daughter would sleep ~18 hours a day prior to Resveratrol, but is now sleeping no more than 14 hours. She was not crawling at one year, but began an "army crawl" within 24 hours of her first resveratrol dose. Her babbling is much improved as well as all gross and fine motor skills. All I can say is that it has been a truly remarkable transformation.

I just felt the need to mention my personal experiences with Resveratrol. FWIW, I did receive some samples of synthetic resveratrol, but am currently using Anthony Loera's 99% X500 caps. Kudos to Anthony for providing such a fine product.

Also, I was told to take EGCg with resveratrol. I buy the "Teavigo" formulation from vitacost.com.

Great forum.

Edited by exotiq, 14 March 2008 - 01:48 AM.

[niner]

Thanks for the great report, exotiq. I hope that your daughter continues to improve. I think that you've made a good choice with RevGenetics. Anthony is a good guy and puts out a good product. Please stop in from time to time and let us know how things are going.

[exotiq]

Thanks Niner, will do. I've spent a lot of time in Philly [PHLX and Manayunk], great town.

[maxwatt]

...

Also, I was told to take EGCg with resveratrol. I buy the "Teavigo" formulation from vitacost.com.

Great forum.

Who recommended EGCG to you, and what was the reasoning?

[inawe]

Exotiq,
There is some good research on supplements but there is also a lot of
fluff. So it's great to hear when a supplement is actually helping
people (not just yeast, mice and rats). Guess you are doing all of this under the supervision of a
doctor. Hopefully your daughter will continue to improve. Then, it'll be
interesting to have a paper written. It might help others in similar
situations.

[stephen_b]

Just wondering, how much does your daughter weigh? Assuming 50th percentile for weight at age 14 months, that would be 19.5 pounds (8.85 kg), and her dosage would be 22.6 mg/kg. As it turns out, I take almost that exact amount. Best wishes for your daughter.

Stephen

[exotiq]

Max -- I have sent an email to the Doc who recommended the EGCg. IIRC, it was inhibition of sulfonation but I am not sure.

Inawe -- Thanks, quite a few PWS patients are taking CoQ10, RSV, among others.

Stephen -- I realize it's a large dose. My daughter is 20lbs. She seems to tolerate it very well and we monitor her bloodwork.

Edited by exotiq, 14 March 2008 - 07:02 PM.

[sUper GeNius]

...

Also, I was told to take EGCg with resveratrol. I buy the "Teavigo" formulation from vitacost.com.

Great forum.

Who recommended EGCG to you, and what was the reasoning?

Maxwatt, can you try it and let us know if the big toe, (nickname?,) likes it?

[Forever_Young]

I am new to this site. I was wondering if anybody has tried eresveratrol-200mg. It comes in a Licap made capsule with nitrogen bubble. Since resveratrol is air sensitive I am guessing this prolongs the lifetime of resveratrol. Also the price looks very resonable. The product is sold by a doctor who appears to be using it and giving to his patients. So I am guessing there is more credbility. I am thinking of buying some for me and my family and if you could give me some pointers I would really apprecitae. The web site is http://eresveratrol.com/
thanks

[maxwatt]

...

Also, I was told to take EGCg with resveratrol. I buy the "Teavigo" formulation from vitacost.com.

Great forum.

Who recommended EGCG to you, and what was the reasoning?

Maxwatt, can you try it and let us know if the big toe, (nickname?,) likes it?

I drink 4 or 5 big cups of green tea a day, so I am probably getting 200 mg of EGCG already. It doesn't interfere with the effects of resveratrol. And it's water soluble, so it's highly bioavailable.
I am thinking of trying EGCG in place of resveratrol and giving it the toe test.

[sUper GeNius]

I am new to this site. I was wondering if anybody has tried eresveratrol-200mg. It comes in a Licap made capsule with nitrogen bubble. Since resveratrol is air sensitive I am guessing this prolongs the lifetime of resveratrol. Also the price looks very resonable. The product is sold by a doctor who appears to be using it and giving to his patients. So I am guessing there is more credbility. I am thinking of buying some for me and my family and if you could give me some pointers I would really apprecitae. The web site is http://eresveratrol.com/
thanks

This post seems spammy, but assuming you are sincere, I'll get you started: resveratrol is not very "air sensitive." Search the "500 mg" thread. T-res is actually quite stable, as long as you don't store it directly under your UV lamp.

[sUper GeNius]

...

Also, I was told to take EGCg with resveratrol. I buy the "Teavigo" formulation from vitacost.com.

Great forum.

Who recommended EGCG to you, and what was the reasoning?

Maxwatt, can you try it and let us know if the big toe, (nickname?,) likes it?

I drink 4 or 5 big cups of green tea a day, so I am probably getting 200 mg of EGCG already. It doesn't interfere with the effects of resveratrol. And it's water soluble, so it's highly bioavailable.
I am thinking of trying EGCG in place of resveratrol and giving it the toe test.

Have you been drinking the tea the whole time you've been taking t-res? If so, I wonder how much of an influence it has had on your toe? Perhaps you should try cutting out the tea in order to find out.

Edited by FuLL meMbeR, 14 March 2008 - 09:21 PM.

[maxwatt]

I am new to this site. I was wondering if anybody has tried eresveratrol-200mg. It comes in a Licap made capsule with nitrogen bubble. Since resveratrol is air sensitive I am guessing this prolongs the lifetime of resveratrol. Also the price looks very resonable. The product is sold by a doctor who appears to be using it and giving to his patients. So I am guessing there is more credbility. I am thinking of buying some for me and my family and if you could give me some pointers I would really apprecitae. The web site is http://eresveratrol.com/
thanks

This post seems spammy, but assuming you are sincere, I'll get you started: resveratrol is not very "air sensitive." Search the "500 mg" thread. T-res is actually quite stable, as long as you don't store it directly under your UV lamp.

Eresveratrol contains:

... 200 mg of 99% pure trans-resveratrol in a vehicle containing lecithin and glycerolmonostearate (an emulsifier) to improve absorption. Mixed tocopherols (as an antioxidant) and 50 mg of quercetin were added to enhance trans-resveratrol bioavailability. These capsules are Licaps (Pfizer) made in a nitrogen atmosphere with an internal nitrogen bubble to prevent degradation of trans-resveratrol to the inactive form of cis-resveratrol and for long term preservation of freshness. A dose of 2 capsules per day (400 mg total) of trans-resveratrol is the approximate dose that David Sinclair of Harvard stated he was taking.

The Licaps are overkill as Fuelmember pointed out. The lecithin is good, improves availability. But 50 mg per capsule is probably way too much, as a quercetin metabolite blocks Sirt1 countering the positive efect of resveratrol. It has been discussed elsewhere on this site, that although a little quercetin blocks sulfonation of resveratrol, more than 15 to 25 mg at a time is counterproductive.

[maxwatt]

...

Also, I was told to take EGCg with resveratrol. I buy the "Teavigo" formulation from vitacost.com.

Great forum.

Who recommended EGCG to you, and what was the reasoning?

Maxwatt, can you try it and let us know if the big toe, (nickname?,) likes it?

I drink 4 or 5 big cups of green tea a day, so I am probably getting 200 mg of EGCG already. It doesn't interfere with the effects of resveratrol. And it's water soluble, so it's highly bioavailable.
I am thinking of trying EGCG in place of resveratrol and giving it the toe test.

Have you been drinking the tea the whole time you've been taking t-res? If so, I wonder how much of an influence it has had on your toe? Perhaps you should try cutting out the tea in order to find out.

I went a week without tea while visiting relatives, and the resveratrol was still effective vis-a-vis arthritis symptoms.

[niner]

Eresveratrol contains:

... 200 mg of 99% pure trans-resveratrol in a vehicle containing lecithin and glycerolmonostearate (an emulsifier) to improve absorption. Mixed tocopherols (as an antioxidant) and 50 mg of quercetin were added to enhance trans-resveratrol bioavailability. These capsules are Licaps (Pfizer) made in a nitrogen atmosphere with an internal nitrogen bubble to prevent degradation of trans-resveratrol to the inactive form of cis-resveratrol and for long term preservation of freshness. A dose of 2 capsules per day (400 mg total) of trans-resveratrol is the approximate dose that David Sinclair of Harvard stated he was taking.

The Licaps are overkill as Fuelmember pointed out. The lecithin is good, improves availability. But 50 mg per capsule is probably way too much, as a quercetin metabolite blocks Sirt1 countering the positive efect of resveratrol. It has been discussed elsewhere on this site, that although a little quercetin blocks sulfonation of resveratrol, more than 15 to 25 mg at a time is counterproductive.

Agree about the licaps and nitrogen; not needed. It's a pretty decent formulation, but at $3.33/gm resveratrol, it's kind of steep by today's standards. Not outrageous, though, if it really contains what it claims. Just because the guy is a doctor means nothing. I know some doctors that are dangerous quacks. The website overpromotes the wonders of resveratrol, imho. And what's the dark yellow stuff in these caps? Most of the contents should be white AFAIK, with maybe the exception of the lecithin which might be a light golden color. What else would it be? The mixed tocopherols? Impure resveratrol instead of the claimed 99%? Maxwatt, any idea on the color? (I was looking at the larger image of the product on the ordering page.)

[sUper GeNius]

Eresveratrol contains:

... 200 mg of 99% pure trans-resveratrol in a vehicle containing lecithin and glycerolmonostearate (an emulsifier) to improve absorption. Mixed tocopherols (as an antioxidant) and 50 mg of quercetin were added to enhance trans-resveratrol bioavailability. These capsules are Licaps (Pfizer) made in a nitrogen atmosphere with an internal nitrogen bubble to prevent degradation of trans-resveratrol to the inactive form of cis-resveratrol and for long term preservation of freshness. A dose of 2 capsules per day (400 mg total) of trans-resveratrol is the approximate dose that David Sinclair of Harvard stated he was taking.

The Licaps are overkill as Fuelmember pointed out. The lecithin is good, improves availability. But 50 mg per capsule is probably way too much, as a quercetin metabolite blocks Sirt1 countering the positive efect of resveratrol. It has been discussed elsewhere on this site, that although a little quercetin blocks sulfonation of resveratrol, more than 15 to 25 mg at a time is counterproductive.

Agree about the licaps and nitrogen; not needed. It's a pretty decent formulation, but at $3.33/gm resveratrol, it's kind of steep by today's standards. Not outrageous, though, if it really contains what it claims. Just because the guy is a doctor means nothing. I know some doctors that are dangerous quacks. The website overpromotes the wonders of resveratrol, imho. And what's the dark yellow stuff in these caps? Most of the contents should be white AFAIK, with maybe the exception of the lecithin which might be a light golden color. What else would it be? The mixed tocopherols? Impure resveratrol instead of the claimed 99%? Maxwatt, any idea on the color? (I was looking at the larger image of the product on the ordering page.)

My guess is it's either due to the lecithin, or that is the color of the licap. I have bought black licaps from Vitacost. See this page for an amber color:

http://images.google...t...Den-us&sa=N

Also here, where they mention that different colors are available.

http://www.capsugel....ucts/licaps.php

Edited by FuLL meMbeR, 15 March 2008 - 04:25 AM.

[speedlet]

...

Also, I was told to take EGCg with resveratrol. I buy the "Teavigo" formulation from vitacost.com.

Great forum.

Who recommended EGCG to you, and what was the reasoning?

Maxwatt, can you try it and let us know if the big toe, (nickname?,) likes it?

I drink 4 or 5 big cups of green tea a day, so I am probably getting 200 mg of EGCG already. It doesn't interfere with the effects of resveratrol. And it's water soluble, so it's highly bioavailable.
I am thinking of trying EGCG in place of resveratrol and giving it the toe test.

Wait a minute.

I thought EGCG deactivated SIRT-1, making it counteractive to the effects of Resveratrol.

I read this on this site. Is this true or not?

[maxwatt]

...

Also, I was told to take EGCg with resveratrol. I buy the "Teavigo" formulation from vitacost.com.

Great forum.

Who recommended EGCG to you, and what was the reasoning?

Maxwatt, can you try it and let us know if the big toe, (nickname?,) likes it?

I drink 4 or 5 big cups of green tea a day, so I am probably getting 200 mg of EGCG already. It doesn't interfere with the effects of resveratrol. And it's water soluble, so it's highly bioavailable.
I am thinking of trying EGCG in place of resveratrol and giving it the toe test.

Wait a minute.

I thought EGCG deactivated SIRT-1, making it counteractive to the effects of Resveratrol.

I read this on this site. Is this true or not?

That is quercetin you ae thinking of. One of it's metabolites inactivates SIRT1. EGCG activates SIRT1 "under stabilizing conditions." You can find the paper and the references to it with google. The assay was performed

in vitro

. But inside the body, the oxygen content is 5%, and the stabilizing conditions were the presence of anti-oxidants.

[bixbyte]

I run a hedge/PE fund with a focus on buy-side trading of structured-products; exotic options, var-swaps and mortgage instruments; CDO, CDO^2, CDS, etc. I also invest (seed -> mezz financing) in biotech/pharma. As a disclaimer: I was an early PE-investor in S*rt*s.

I own some SIRT stock.

If what you say is true, why doesn't SIRT make some claims that their SRT-501 helps this syndrome?

Thank You

[niner]

I run a hedge/PE fund with a focus on buy-side trading of structured-products; exotic options, var-swaps and mortgage instruments; CDO, CDO^2, CDS, etc. I also invest (seed -> mezz financing) in biotech/pharma. As a disclaimer: I was an early PE-investor in S*rt*s.

I own some SIRT stock.

If what you say is true, why doesn't SIRT make some claims that their SRT-501 helps this syndrome?

Thank You

The title of this thread is "Anecdotes", after all. But Sirtris has made claims regarding MELAS, a mitochondrial syndrome, which might at least somewhat relate to exotiq's daughter's condition, and also regarding diabetes, which I think is also a later component of her condition.

[exotiq]

I run a hedge/PE fund with a focus on buy-side trading of structured-products; exotic options, var-swaps and mortgage instruments; CDO, CDO^2, CDS, etc. I also invest (seed -> mezz financing) in biotech/pharma. As a disclaimer: I was an early PE-investor in S*rt*s.

I own some SIRT stock.

If what you say is true, why doesn't SIRT make some claims that their SRT-501 helps this syndrome?

Thank You

No offense intended, but I don't owe you an explanation, nor does it serve me to lie about my business or my daughter's condition. I simply wanted to be straightforward about my financial interest in S*rt*s before making any comments regarding my daughter's improvement while on Resveratrol. My comments relate to the compound, not the manufacturer of the analog. My wife and I are simply thankful that Resveratrol was recommended to us; and I wished to thank Anthony Loera at Revgenetics.

The fact remains that very little synthetic Resveratrol was used. The majority of the benefits we've seen were the result of taking the natural compound rather than the synthetic analog.

[sUper GeNius]

I run a hedge/PE fund with a focus on buy-side trading of structured-products; exotic options, var-swaps and mortgage instruments; CDO, CDO^2, CDS, etc. I also invest (seed -> mezz financing) in biotech/pharma. As a disclaimer: I was an early PE-investor in S*rt*s.

I own some SIRT stock.

If what you say is true, why doesn't SIRT make some claims that their SRT-501 helps this syndrome?

Thank You

No offense intended, but I don't owe you an explanation, nor does it serve me to lie about my business or my daughter's condition. I simply wanted to be straightforward about my financial interest in S*rt*s before making any comments regarding my daughter's improvement while on Resveratrol. My comments relate to the compound, not the manufacturer of the analog. My wife and I are simply thankful that Resveratrol was recommended to us; and I wished to thank Anthony Loera at Revgenetics.

The fact remains that very little synthetic Resveratrol was used. The majority of the benefits we've seen were the result of taking the natural compound rather than the synthetic analog.

I think you may be taking his question the wrong way.

[niner]

I run a hedge/PE fund with a focus on buy-side trading of structured-products; exotic options, var-swaps and mortgage instruments; CDO, CDO^2, CDS, etc. I also invest (seed -> mezz financing) in biotech/pharma. As a disclaimer: I was an early PE-investor in S*rt*s.

I own some SIRT stock.

If what you say is true, why doesn't SIRT make some claims that their SRT-501 helps this syndrome?

Thank You

No offense intended, but I don't owe you an explanation, nor does it serve me to lie about my business or my daughter's condition. I simply wanted to be straightforward about my financial interest in S*rt*s before making any comments regarding my daughter's improvement while on Resveratrol. My comments relate to the compound, not the manufacturer of the analog. My wife and I are simply thankful that Resveratrol was recommended to us; and I wished to thank Anthony Loera at Revgenetics.

The fact remains that very little synthetic Resveratrol was used. The majority of the benefits we've seen were the result of taking the natural compound rather than the synthetic analog.

I think you may be taking his question the wrong way.

It sounded pretty accusatory, imho... even if it wasn't meant that way.

[sUper GeNius]

I run a hedge/PE fund with a focus on buy-side trading of structured-products; exotic options, var-swaps and mortgage instruments; CDO, CDO^2, CDS, etc. I also invest (seed -> mezz financing) in biotech/pharma. As a disclaimer: I was an early PE-investor in S*rt*s.

I own some SIRT stock.

If what you say is true, why doesn't SIRT make some claims that their SRT-501 helps this syndrome?

Thank You

No offense intended, but I don't owe you an explanation, nor does it serve me to lie about my business or my daughter's condition. I simply wanted to be straightforward about my financial interest in S*rt*s before making any comments regarding my daughter's improvement while on Resveratrol. My comments relate to the compound, not the manufacturer of the analog. My wife and I are simply thankful that Resveratrol was recommended to us; and I wished to thank Anthony Loera at Revgenetics.

The fact remains that very little synthetic Resveratrol was used. The majority of the benefits we've seen were the result of taking the natural compound rather than the synthetic analog.

I think you may be taking his question the wrong way.

It sounded pretty accusatory, imho... even if it wasn't meant that way.

It's difficult to judge the intent of the poster's question. To me it seemed that he simply fumbled the delivery. In any case, when a SIRT insider gives private health advice, people listen™ and wonder...

[bixbyte]

No offense intended, but I don't owe you an explanation, nor does it serve me to lie about my business or my daughter's condition. I simply wanted to be straightforward about my financial interest in S*rt*s before making any comments regarding my daughter's improvement while on Resveratrol. My comments relate to the compound, not the manufacturer of the analog. My wife and I are simply thankful that Resveratrol was recommended to us; and I wished to thank Anthony Loera at Revgenetics.

The fact remains that very little synthetic Resveratrol was used. The majority of the benefits we've seen were the result of taking the natural compound rather than the synthetic analog.

Do you think natural resveratrol is more beneficial than the synthetic resveratrol products?

Does S*rt*s sell synthetic resveratrol and Anthony Loera at Revgenetic sell natural?

I am just trying to figure out where to buy the better resveratrol.

Thank You again

[exotiq]

No offense intended, but I don't owe you an explanation, nor does it serve me to lie about my business or my daughter's condition. I simply wanted to be straightforward about my financial interest in S*rt*s before making any comments regarding my daughter's improvement while on Resveratrol. My comments relate to the compound, not the manufacturer of the analog. My wife and I are simply thankful that Resveratrol was recommended to us; and I wished to thank Anthony Loera at Revgenetics.

The fact remains that very little synthetic Resveratrol was used. The majority of the benefits we've seen were the result of taking the natural compound rather than the synthetic analog.

Do you think natural resveratrol is more beneficial than the synthetic resveratrol products?

Does S*rt*s sell synthetic resveratrol and Anthony Loera at Revgenetic sell natural?

I am just trying to figure out where to buy the better resveratrol.

Thank You again

Again, it's anecdotal, but we feel that the bulk of our daughter's improvement came while on the natural product, but we have increased the dose when going with Revgenetics. SIRT does not sell any product. I have no connection with SIRT beyond the conversion from private to public investment. Good luck.

[tintinet]

Thanks for your input. If you don't mind, I've a few questions also.

1. What dose did you start at (synthetic) and what dose have you been using lately (extract)?

2. Are there any other differences in administration (i.e., with food, without food, time of day, all at once or divided doses/day)?

Thanks!

[exotiq]

Thanks for your input. If you don't mind, I've a few questions also.

1. What dose did you start at (synthetic) and what dose have you been using lately (extract)?

2. Are there any other differences in administration (i.e., with food, without food, time of day, all at once or divided doses/day)?

Thanks!

Hi,

100mg with the synthetic. We're currently using ~250mg of Revgenetics 99% upon rising, bolus-gavage, with neocate baby fomula, EPA oil, 50mg Teavigo EGCg, 100mg CoQ10 and 100mg of ALCAR.