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Does Resveratrol Fight Cancer?


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#1 aaaaaaal

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Posted 06 April 2008 - 10:25 PM


Hi,

Was just wondering if theres any evidence to suggest resveratrol fights cancer?

Have there been any studies or is there any evidence to show that it helps combat cancer?

If anyone can post any info AT ALL on how resveratrol can help fight cancer (specifically liver cancer) i would be EXTREMELY grateful.

Just want to get as much information as possible, as time is running out...

many thanks.

#2 Hedgehog

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Posted 06 April 2008 - 11:38 PM

Hi,

Was just wondering if theres any evidence to suggest resveratrol fights cancer?

Have there been any studies or is there any evidence to show that it helps combat cancer?

If anyone can post any info AT ALL on how resveratrol can help fight cancer (specifically liver cancer) i would be EXTREMELY grateful.

Just want to get as much information as possible, as time is running out...

many thanks.


Do a search for "resveratrol liver cancer" if you find any articles that you need access to PM me.

http://www.ncbi.nlm....v/sites/entrez/

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#3 DukeNukem

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Posted 07 April 2008 - 01:11 AM

>>> Was just wondering if theres any evidence to suggest resveratrol fights cancer?

Strongly recommend reading Bill Sardi's recent book, You Don't Have to be Afraid of Cancer Anymore. Lots of resveratrol versus cancer coverage, including references.
  • unsure x 1

#4 exotiq

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Posted 07 April 2008 - 02:50 PM

A friend of mine has melanoma and has been trating the skin lesions with topical resveratrol in DMSO and is thrilled with the results. I don't have a lot of information regarding his progress. I should give him a call.
  • unsure x 1

#5 Anthony_Loera

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Posted 07 April 2008 - 03:19 PM

Remember, most of this stuff is in vitro, or studies on animals:


Deactivation of cultured human liver myofibroblasts by Trans-resveratrol, a grapevine-derived polyphenol
http://www3.intersci...n...=1&SRETRY=0


http://www.agrawal.o...esveratrol1.pdf
Liver
-Inhibits proliferation in rat hepatoma Fao cells ñ⊥ S and G2/M phase (171)
-Suppresses hepatoma cell invasion ñ↓ ROS (172)
-Decreases hepatocyte growth factor-induced HepG2 ñUses an unidentified post-receptor mechanism (173)
cell invasion
-Inhibits hepatoma cell, AH 109A proliferation and ñAntioxidative involved in anti-invasive action (174)
invasion

Some initial human studies are being done here:
http://clinicaltrial...r="Resveratrol"


You can search for more on google scholar for the actual resveratrol and cancer studies:
http://scholar.google.com/

if you use the regular google search, you will get mostly marketing items.

I hope this helps
A

#6 sUper GeNius

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Posted 07 April 2008 - 05:19 PM

A friend of mine has melanoma and has been trating the skin lesions with topical resveratrol in DMSO and is thrilled with the results. I don't have a lot of information regarding his progress. I should give him a call.


Exactly what kind of results is he having?

#7 malbecman

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Posted 07 April 2008 - 08:59 PM

I think the best answer you're going to get is "maybe" or "it looks very promising.....". It's still really too early to tell in humans.

#8 exotiq

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Posted 08 April 2008 - 02:06 AM

A friend of mine has melanoma and has been trating the skin lesions with topical resveratrol in DMSO and is thrilled with the results. I don't have a lot of information regarding his progress. I should give him a call.


Exactly what kind of results is he having?


He told me the lesions would fall off after several days of treatment.

#9 sUper GeNius

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Posted 08 April 2008 - 02:19 AM

A friend of mine has melanoma and has been trating the skin lesions with topical resveratrol in DMSO and is thrilled with the results. I don't have a lot of information regarding his progress. I should give him a call.


Exactly what kind of results is he having?


He told me the lesions would fall off after several days of treatment.


Why aren't the lesions simply surgically removed?
  • Agree x 1

#10 maxwatt

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Posted 08 April 2008 - 11:15 AM

A friend of mine has melanoma and has been trating the skin lesions with topical resveratrol in DMSO and is thrilled with the results. I don't have a lot of information regarding his progress. I should give him a call.


Exactly what kind of results is he having?


He told me the lesions would fall off after several days of treatment.


Why aren't the lesions simply surgically removed?

He is taking a major risk if he isn't having them removed.
  • Agree x 1

#11 Hedgehog

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Posted 09 April 2008 - 09:33 PM

Hi,

Was just wondering if theres any evidence to suggest resveratrol fights cancer?

Have there been any studies or is there any evidence to show that it helps combat cancer?

If anyone can post any info AT ALL on how resveratrol can help fight cancer (specifically liver cancer) i would be EXTREMELY grateful.

Just want to get as much information as possible, as time is running out...

many thanks.


Resveratrol gets degraded very fast which makes it a poor molecule to fight cancer. You would have to take many doses throughout the day to keep systemic levels up.

#12 maxwatt

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Posted 10 April 2008 - 01:45 AM

Hi,

Was just wondering if theres any evidence to suggest resveratrol fights cancer?

Have there been any studies or is there any evidence to show that it helps combat cancer?

If anyone can post any info AT ALL on how resveratrol can help fight cancer (specifically liver cancer) i would be EXTREMELY grateful.

Just want to get as much information as possible, as time is running out...

many thanks.


Resveratrol gets degraded very fast which makes it a poor molecule to fight cancer. You would have to take many doses throughout the day to keep systemic levels up.


Perhaps topical application to a skin growth, held in place with an occlusive bandage, would get enough resveratrol locally at a specific site. Still, if you have a diagnosed melanoma, you want it removed as quickly as possible.

#13 Hedgehog

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Posted 11 April 2008 - 04:48 AM

Hi,

Was just wondering if theres any evidence to suggest resveratrol fights cancer?

Have there been any studies or is there any evidence to show that it helps combat cancer?

If anyone can post any info AT ALL on how resveratrol can help fight cancer (specifically liver cancer) i would be EXTREMELY grateful.

Just want to get as much information as possible, as time is running out...

many thanks.


I have done some research on the Hedgehog (Hh) pathway and currently there are three ongoing clinical studies maybe 4. Depending on your grade of cancer the Hh pathway might be of interest to you. The Hh pathway is basically like a gas pedal for cancer. For us cancer researchers the grade of the cancer is very often dependent on Hh pathway activation (the Hh pathway is like a master switch for growth factors like EGFR, VEGF). The more the Hh pathway is turned on the worse the grade of cancer is. This has been studied with colon, pancreatic, breast, prostate, liver, gliomas, medulloblastoma, small cell lung cancers... ect this list goes on... Anyways to make a long story short there are a few natural inhibitors of this pathway.


  • Cyclopamine found in corn lillys in the sierra's (California)
  • Zerumbone more can be found here (pubmed article)
I'm very familiar w/ cyclopamine and its structure is very different compared to zerumbone.

We have identified several types of naturally occurring inhibitors of GLI-mediated transcription by using a cell-based assay;


different mechanism of action from cyclopamine, which is an inhibitor of Smo.


This is very BIG statement. Won't go into much detail but SMO is upstream in the hedgehog pathway where as GLI is a activator of gene transcription. If you inhibit GLI you don't have to worry about upstream mutations in the pathway. GLI is the most downstream target! Having said all of that we don't really how well zerumbone will diffuse into the cell or even into the nucleus.

more info about zerumbone can be found here http://zerumbone.com/

A few more articles

Activation of the hedgehog pathway in human hepatocellular carcinomas.

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.

#14 missminni

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Posted 20 April 2008 - 05:07 PM

Hi,

Was just wondering if theres any evidence to suggest resveratrol fights cancer?

Have there been any studies or is there any evidence to show that it helps combat cancer?

If anyone can post any info AT ALL on how resveratrol can help fight cancer (specifically liver cancer) i would be EXTREMELY grateful.

Just want to get as much information as possible, as time is running out...

many thanks.

for what it's worth, my female dog was diagnosed with terminal mammary cancer in January. They gave
her 6 mo. to live. They removed the growth, 3 mammary glands and one lymph gland and said it was too late for treatment, it had gone to far.
I have her on 5 to 6 grams of res a day and she is doing great, looks amazing and shows no signs of illness. In fact, her hind
legs which were weak from torn cruciate ligaments are straighter and stronger than ever before. Of course I will not celebrate until we pass July. but I can say she has never looked or acted healthier since she was a puppy. She's 9 and a half.


#15 sthira

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Posted 20 April 2008 - 05:21 PM

hey missminnie, where do you buy such large doses of resv? do you just mix it in with her daily food?

Edited by sthira, 20 April 2008 - 05:22 PM.


#16 missminni

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Posted 20 April 2008 - 06:33 PM

hey missminnie, where do you buy such large doses of resv? do you just mix it in with her daily food?

I buy it in bulk (kilos). I mix it in her food. I dissolve it in some milk
and then add it to her food (about 5-6 g once a day).


#17 sUper GeNius

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Posted 21 April 2008 - 12:23 PM

hey missminnie, where do you buy such large doses of resv? do you just mix it in with her daily food?

I buy it in bulk (kilos). I mix it in her food. I dissolve it in some milk
and then add it to her food (about 5-6 g once a day).


I hope it works out for your dog missminni. My 11 yrd old dog has responded very well to supplements, going from a slow walker, to actually running me around the block now. A very impressive change. I don't think it's the resveratrol, as much as it is the recent addition of alpha lipoic acid and acetyl carnitine. There might be some synergy going on too. An amazing change in m dog's behavior, used to just mozy around on his walk, recently however he trots for blocks. I actually have to run to keep up with him. I get tired before he does!

#18 malbecman

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Posted 21 April 2008 - 04:22 PM

missminni, I hope it works out for your dog as well. My older dog is on a much lower dose, ( ca 0.5gr, sometimes irregularly given) and I've definitely noticed an energy improvement, even though she's only ~6 yrs old. I intend to ramp things up as she gets a little older.

FuLL meMbeR, how much and how do you give your dog ALCAR and ALA? I hope he runs your legs off. ;o)


Thanks.

Malbec

hey missminnie, where do you buy such large doses of resv? do you just mix it in with her daily food?

I buy it in bulk (kilos). I mix it in her food. I dissolve it in some milk
and then add it to her food (about 5-6 g once a day).


I hope it works out for your dog missminni. My 11 yrd old dog has responded very well to supplements, going from a slow walker, to actually running me around the block now. A very impressive change. I don't think it's the resveratrol, as much as it is the recent addition of alpha lipoic acid and acetyl carnitine. There might be some synergy going on too. An amazing change in m dog's behavior, used to just mozy around on his walk, recently however he trots for blocks. I actually have to run to keep up with him. I get tired before he does!



#19 sUper GeNius

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Posted 21 April 2008 - 07:16 PM

missminni, I hope it works out for your dog as well. My older dog is on a much lower dose, ( ca 0.5gr, sometimes irregularly given) and I've definitely noticed an energy improvement, even though she's only ~6 yrs old. I intend to ramp things up as she gets a little older.

FuLL meMbeR, how much and how do you give your dog ALCAR and ALA? I hope he runs your legs off. ;o)


Thanks.

Malbec

hey missminnie, where do you buy such large doses of resv? do you just mix it in with her daily food?

I buy it in bulk (kilos). I mix it in her food. I dissolve it in some milk
and then add it to her food (about 5-6 g once a day).


I hope it works out for your dog missminni. My 11 yrd old dog has responded very well to supplements, going from a slow walker, to actually running me around the block now. A very impressive change. I don't think it's the resveratrol, as much as it is the recent addition of alpha lipoic acid and acetyl carnitine. There might be some synergy going on too. An amazing change in m dog's behavior, used to just mozy around on his walk, recently however he trots for blocks. I actually have to run to keep up with him. I get tired before he does!


I give him one half of one of these caps:

http://www.vitacost....ine-60-Capsules

I looked through some info posted here about dosages given to dogs (juvenon, a few references on their site too and via google.) I think I'm actually giving him a bit less on a per lb basis than was used in the studies. I also give him about 300mg of 98% resveratrol. Seem like such a good thing when something like this works out. I wonder why it's not having the same effect on me. I'm taking the same stuff. Maybe less to gain, as I am quite a bit younger in human/human equivalent years.

#20 malbecman

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Posted 21 April 2008 - 09:35 PM

Thanks, FuLL meMbeR. I'm glad my lab has not gone to flab yet, otherwise this could get expensive... ;o)



missminni, I hope it works out for your dog as well. My older dog is on a much lower dose, ( ca 0.5gr, sometimes irregularly given) and I've definitely noticed an energy improvement, even though she's only ~6 yrs old. I intend to ramp things up as she gets a little older.

FuLL meMbeR, how much and how do you give your dog ALCAR and ALA? I hope he runs your legs off. ;)


Thanks.

Malbec

hey missminnie, where do you buy such large doses of resv? do you just mix it in with her daily food?

I buy it in bulk (kilos). I mix it in her food. I dissolve it in some milk
and then add it to her food (about 5-6 g once a day).


I hope it works out for your dog missminni. My 11 yrd old dog has responded very well to supplements, going from a slow walker, to actually running me around the block now. A very impressive change. I don't think it's the resveratrol, as much as it is the recent addition of alpha lipoic acid and acetyl carnitine. There might be some synergy going on too. An amazing change in m dog's behavior, used to just mozy around on his walk, recently however he trots for blocks. I actually have to run to keep up with him. I get tired before he does!


I give him one half of one of these caps:

http://www.vitacost....ine-60-Capsules

I looked through some info posted here about dosages given to dogs (juvenon, a few references on their site too and via google.) I think I'm actually giving him a bit less on a per lb basis than was used in the studies. I also give him about 300mg of 98% resveratrol. Seem like such a good thing when something like this works out. I wonder why it's not having the same effect on me. I'm taking the same stuff. Maybe less to gain, as I am quite a bit younger in human/human equivalent years.



#21 exotiq

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Posted 27 April 2008 - 02:48 PM

A friend of mine has melanoma and has been trating the skin lesions with topical resveratrol in DMSO and is thrilled with the results. I don't have a lot of information regarding his progress. I should give him a call.


Exactly what kind of results is he having?


He told me the lesions would fall off after several days of treatment.


Why aren't the lesions simply surgically removed?

He is taking a major risk if he isn't having them removed.



They have been removed surgically. These are recurrences. He's stage 4.

#22 maxwatt

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Posted 27 April 2008 - 03:33 PM

A friend of mine has melanoma and has been trating the skin lesions with topical resveratrol in DMSO and is thrilled with the results. I don't have a lot of information regarding his progress. I should give him a call.


Exactly what kind of results is he having?


He told me the lesions would fall off after several days of treatment.


Why aren't the lesions simply surgically removed?

He is taking a major risk if he isn't having them removed.



They have been removed surgically. These are recurrences. He's stage 4.

I wish him luck.

#23 missminni

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Posted 27 April 2008 - 04:16 PM

I wish him luck.

Me too. We are approaching the 5 month of Minni's "6 month to live" verdict and although
she is doing really well in every way I am taking her to see the vet at AMC because I noticed some spots near her
scar sight that are either stitiches or staples that were not properly removed and are causing irritation that
doesn't seem to resolve. I am so hoping to hear it's nothing serious. I put her back on ClavaMox in the meantime. I had
some left from a 30 day supply. Keep your fingers crossed.


#24 missminni

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Posted 02 May 2008 - 12:39 AM

Minni just got a stellar check up. The vet couldn't believe how
healthy she is considering her biopsy report from Jan 8th would have her a month away from
the end of life.
She should have shown a decline by now if the cancer was proceeding, but it was quite the contrary.
She is healthy as can be and the vet is very excited about resveratrol. Asked lots of questions
about dosage etc. I wish they could do their own clinical trials at AMC, but she said they
usually do ones that are sponsored by drug companies, so I sent her Sirtis info. Who knows.
She is going to talk to some of the internists at the Hospital to see if they are interested
in pursuing it. I gave her the link to Imminst so she could read up on it.


#25 Anthony_Loera

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Posted 02 May 2008 - 12:51 AM

Great news!

You used the 98% resveratrol powder correct?

A

#26 missminni

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Posted 02 May 2008 - 01:14 AM

Great news!

You used the 98% resveratrol powder correct?

A

Yes. 98%. I give her between 4 to 6 grams a day in one feeding. She's a 94 lb dog.
A friend of mine whose dog was also diagnosed with advanced cancer about the same time as Minni has been
giving her dog Resveratrol too, and when she took her to see the vet last week, the vet was surprised that
she was such good health. Her dog is 60 lbs and she is giving her 1 tablespoon a day,
which is about 3 grams. She's a golden lab, and has a very large massive cancerous tumor on her belly.
They didn't expect her to live without chemo, but she is still very much alive and no chemo.
She is also nine years old and on anti-seizure
medication.
She's doing great on Res and the tumor has not advanced. In fact, it might be getting smaller.
Will keep you posted.


#27 ksfamily

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Posted 02 May 2008 - 02:10 AM

How is your friend with the Stage 4 melanoma? We have a case in the family that is still undergoing diagnosis and planning of treatment.

#28 missminni

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Posted 02 May 2008 - 02:17 AM

How is your friend with the Stage 4 melanoma? We have a case in the family that is still undergoing diagnosis and planning of treatment.

I wasn't sure if you were asking me this question ?? but I don't have a friend in stage 4 melanoma.


#29 Heliotrope

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Posted 02 May 2008 - 02:20 AM

here's to the red wine. ahhh nothing beats a glass after a long day of school and now i gotta study for these final exams, hope i don't go take them drunk

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#30 tintinet

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Posted 02 May 2008 - 06:16 PM

How is your friend with the Stage 4 melanoma? We have a case in the family that is still undergoing diagnosis and planning of treatment.

I wasn't sure if you were asking me this question ?? but I don't have a friend in stage 4 melanoma.


Reference is to friend of exotiq. Vide supra.




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