I was on SSRIs (Zoloft, Prozac) and Effexor at various times over a 12 year period. The SSRIs definitely took the edge off and made me feel more "normal"/less bitchy. Only problem is they also made me exhausted with zero libido and I gained 60 lbs. Effexor made me fat and somewhat irritable. I weaned off of everything last year (and lost 40 lbs) and was doing great, but for the last 3 months I've fallen back into depression/anxiety.
I tried Wellbutrin and for 1 week it made me very happy/horny, but that quickly turned into feeling very irritable so I quit taking it. Now I have no idea what to do. I'm taking pharmaceutical grade fish oil (high EPA - 1.5 grams) daily with a multi, maca, inositol, extra B vitamins, 5-HTP and SAM-e. I am still very moody, unmotivated, anxious and depressed. Extremely irritable most days. :( I don't want to have to go back on medication, but I'm afraid I'll have to if I can't figure out my brain issues soon.