3 replies to this topic

[Chrisalias]

I've noticed that some people take their supplements in rotation....usually 5 days on followed by 2 days off...weekends I assume.
I have always taken my supplements 365 days a year, but have often wondered about that approach.

I'd like to hear more about the reasoning behind the rotation and if all supplements should be rotated..even the Multi=V?

Thanks
Chris

[zoolander]

reasoning from my side is that there isn't, for most, a lot of long term chronic studies in humans using supps and nutraceutical. hence, I give my body a rest 2 days a week and then give my body a rest for 2 weeks every 3 months. I'm considering taking a month of once a year. I'll just not supplement in January.

It also cost a hell of a lot less if you don't take supps everyday. for example, cutting 2 days a week turns 2 months (60 days) supply into 3 months supply (90 days)

[Jacovis]

reasoning from my side is that there isn't, for most, a lot of long term chronic studies in humans using supps and nutraceutical. hence, I give my body a rest 2 days a week and then give my body a rest for 2 weeks every 3 months. I'm considering taking a month of once a year. I'll just not supplement in January.

It also cost a hell of a lot less if you don't take supps everyday. for example, cutting 2 days a week turns 2 months (60 days) supply into 3 months supply (90 days)

I know there probably isn't much research on this but what about any possible damage from regularly suddenly stopping such high amounts (well compared to RDAs anyway) of vitamins/minerals/herbs that a lot of people take here. For example see the quoted text below - note they are only talking about Vitamin B6 and C but couldn't the same principle apply with other nutrients...

http://www.quantium....com/lr/lr91.htm
"...More than 200mg/d of B6 (pyridoxine) has been reported to induce a transient dependency32. As with the rebound effect this is actually an indication that the high dose is metabolically active, rather than wasted, as many authorities believe. Nevertheless, going cold turkey is probably an experience to be avoided. As with the rebound effect, should you decide to stop supplementing, the advice is to taper off any high intakes slowly, rather than quickly...

[32] A Guide to AntiAging Drugs. Thomas Donaldson (1997) ISBN 096421900 Is the most compact source of anti-aging information available and the inspiration for this monograph."

http://groups.google...780cd5b9cfbf65/
"With cycling you lose the putative benefit that comes from habituation:

from http://mcp.longevity-report.com


Beware of the "rebound effect"; sudden cessation of the intake of a vitamin
may induce a temporary depletion in that vitamin to below
pre-supplementation levels and occasionally the appearance of the associated
deficiency syndrome. This can be avoided by gradually reducing your intake
over a period of weeks, rather than suddenly. The rebound effect has been
observed with vitamin C (ascorbic acid) when intake was dropped from 10g/d
to 125mg/d[44]. The rebound phenomenon is actually evidence for the
effectiveness of high doses of vitamins and disproves the common mythology
that excess vitamins are wasted. As the study[44] found "We hypothesize
that the high intake of ascorbic acid has induced the formation of increased
amounts of enzymes that help convert the ascorbic acid into other substances
and that these substances are valuable."


[44]Med Hypotheses 1984 Mar;13(3):303-10


Evidence of rebound effect with ascorbic acid.


Tsao CS, Salimi SL.


The urinary excretion pattern of ascorbic acid in two subjects who had been
taking a large amount of ascorbic acid (10 g per day) and later reverted to
a small intake (125 mg per day) is described. The ascorbic acid
concentration in the 24-hour urine samples was measured over a 40-day
collection of this period. The mean urinary ascorbic acid excretion during
the loading period of the two subjects was about 2 g per day. Upon
termination of the high intake of ascorbic acid, urinary ascorbic acid
excretion dropped to presupplementation levels within 6 days. Urinary
ascorbic acid of the two subjects continued to decrease to below basal
level, and remained at abnormally low levels for 10 and 12 days
respectively. We hypothesize that the high intake of ascorbic acid has
induced the formation of increased amounts of enzymes that help convert the
ascorbic acid into other substances and that these substances are valuable.
Some possible physiological actions of these ascorbic acid metabolites are
discussed.


PMID: 6717321..."

[Chrisalias]

reasoning from my side is that there isn't, for most, a lot of long term chronic studies in humans using supps and nutraceutical. hence, I give my body a rest 2 days a week and then give my body a rest for 2 weeks every 3 months. I'm considering taking a month of once a year. I'll just not supplement in January.

It also cost a hell of a lot less if you don't take supps everyday. for example, cutting 2 days a week turns 2 months (60 days) supply into 3 months supply (90 days)

I know there probably isn't much research on this but what about any possible damage from regularly suddenly stopping such high amounts (well compared to RDAs anyway) of vitamins/minerals/herbs that a lot of people take here. For example see the quoted text below - note they are only talking about Vitamin B6 and C but couldn't the same principle apply with other nutrients...

http://www.quantium....com/lr/lr91.htm
"...More than 200mg/d of B6 (pyridoxine) has been reported to induce a transient dependency32. As with the rebound effect this is actually an indication that the high dose is metabolically active, rather than wasted, as many authorities believe. Nevertheless, going cold turkey is probably an experience to be avoided. As with the rebound effect, should you decide to stop supplementing, the advice is to taper off any high intakes slowly, rather than quickly...

[32] A Guide to AntiAging Drugs. Thomas Donaldson (1997) ISBN 096421900 Is the most compact source of anti-aging information available and the inspiration for this monograph."

http://groups.google...780cd5b9cfbf65/
"With cycling you lose the putative benefit that comes from habituation:

from http://mcp.longevity-report.com


Beware of the "rebound effect"; sudden cessation of the intake of a vitamin
may induce a temporary depletion in that vitamin to below
pre-supplementation levels and occasionally the appearance of the associated
deficiency syndrome. This can be avoided by gradually reducing your intake
over a period of weeks, rather than suddenly. The rebound effect has been
observed with vitamin C (ascorbic acid) when intake was dropped from 10g/d
to 125mg/d[44]. The rebound phenomenon is actually evidence for the
effectiveness of high doses of vitamins and disproves the common mythology
that excess vitamins are wasted. As the study[44] found "We hypothesize
that the high intake of ascorbic acid has induced the formation of increased
amounts of enzymes that help convert the ascorbic acid into other substances
and that these substances are valuable."


[44]Med Hypotheses 1984 Mar;13(3):303-10


Evidence of rebound effect with ascorbic acid.


Tsao CS, Salimi SL.


The urinary excretion pattern of ascorbic acid in two subjects who had been
taking a large amount of ascorbic acid (10 g per day) and later reverted to
a small intake (125 mg per day) is described. The ascorbic acid
concentration in the 24-hour urine samples was measured over a 40-day
collection of this period. The mean urinary ascorbic acid excretion during
the loading period of the two subjects was about 2 g per day. Upon
termination of the high intake of ascorbic acid, urinary ascorbic acid
excretion dropped to presupplementation levels within 6 days. Urinary
ascorbic acid of the two subjects continued to decrease to below basal
level, and remained at abnormally low levels for 10 and 12 days
respectively. We hypothesize that the high intake of ascorbic acid has
induced the formation of increased amounts of enzymes that help convert the
ascorbic acid into other substances and that these substances are valuable.
Some possible physiological actions of these ascorbic acid metabolites are
discussed.


PMID: 6717321..."

So it looks like the jury is still out on whether it is better to cycle or not when it comes to supplementation........hmmmm not sure how I'll proceed given the facts/conjecture as we know them

Chris