6 replies to this topic

[Bghead8che]

Hi Guys,

Am I curious if anyone has tried Lactium an isolate from milk used mainly for stress and anxiety. http://www.lactiumusa.com/

Any tried this product or have any thoughts on it?

-Brian

[tham]

I was just checking this out today after picking up
its brochure at a local pharmacy.

It's marketed by this local company here in Malaysia.

http://www.rilax.info

Costing a bomb, some M$140 for a box of 30 caps, I think.

Milk protein hydrosylate was also being made by Atrium Bio
as "Procalm", but they have stopped it. You can find it
in Foodscience's "Instacalm" product :

http://www.betterlif...p?prod_id=28196


It's now being made by Biotics Research as "De-Stress".

http://www.bioticsre...s/?254#destress

Edited by tham, 03 May 2008 - 07:13 PM.

[gliche]

This looks good if you need a benzo, and are looking for alternatives or trying to ween off. The research is sketchy on lactium, but I think it has a direct effect on various receptors. Maybe it affects the brain similar to a benzo? With everything I've read on Lactium, I think its more of a drug than a supplement.

I've got no plans to try this, but I would also be interested in any feedback. Below seems to be a quality source

http://www.swansonvi...ernDropBox=null

[Jacovis]

1: Eur J Nutr. 2005 Mar;44(2):128-32. Epub 2004 Nov 2.
Effects of a tryptic hydrolysate from bovine milk alphaS1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations.Messaoudi M, Lefranc-Millot C, Desor D, Demagny B, Bourdon L.
ETAP-Applied Ethology 13, rue du Bois de la Champelle, 54500, Vandoeuvre-lès-Nancy, France. etap@etap-lab.com

BACKGROUND: Preclinical results in rats have demonstrated anxiolytic-like effects of a tryptic bovine alphaS1-casein hydrolysate. AIM OF THE STUDY: We investigated the putative effects of this tryptic hydrolysate on systolic (SBP), diastolic (DBP) blood pressures, heart rate (HR) values and plasma cortisol concentrations (CC) in human healthy volunteers facing successive stress situations. METHODS: The subjects were (double blind) randomly allocated to ingest three times, 12 hours apart, two capsules containing either 200 mg of alphaS1-casein hydrolysate (TS) or bovine skimmed milk powder as a placebo (CS). On the morning of the test day, a first blood sample for baseline measurement of CC was taken before the subjects were submitted to the Stroop test (ST) and, after a 30-min rest, to a Cold Pressor test (CPT). SBP, DBP, and HR were continuously recorded for 5 min before the ST and during each stress situation. A second blood sample was taken 15 min after the end of the CPT condition. RESULTS: ST and ST + CPT combined test situations increased SBP, DBP and HR. The significant "Treatment x SBP" and "Treatment x DBP" interactions indicated the lower percentage changes in SBP and DBP of the TS. In addition, the results showed a significant decrease of the CC in the TS but not in the CS throughout the ST + CPT combined stress tests. HR remained stable in TS between the initial rest period and the CPT unlike what happened in CS. CONCLUSION: On the basis of blood pressure and cortisol changes, these results suggest an antistress profile of this alphaS1-casein hydrolysate in human subjects.

PMID: 15517308 [PubMed - indexed for MEDLINE]


1: Peptides. 2006 Jun;27(6):1476-82. Epub 2005 Nov 21.
A tryptic hydrolysate from bovine milk alphaS1-casein improves sleep in rats subjected to chronic mild stress.Guesdon B, Messaoudi M, Lefranc-Millot C, Fromentin G, Tomé D, Even PC.
UMR INRA 914 Physiologie de la Nutrition et du Comportement Alimentaire, Institut National Agronomique Paris-Grignon, 16 rue Claude Bernard, 75231 Paris Cedex 05, France. guesdon@inapg.fr

The putative effects of a tryptic bovine alphaS1-casein hydrolysate on stress-induced sleep disorders were investigated and their possible link with typical blood stress parameters such as plasma corticosterone concentrations and glycaemia was assessed. Rats were subjected to chronic stress in the form of environmental disturbances, while receiving an oral administration of the alphaS1-casein hydrolysate (CH). Chronic stress significantly reduced sleep duration in control rats during the first 2 days of the stress period, but stress-induced sleep disturbance was prevented in CH-treated rats. Indeed, CH administration allowed the maintenance of slow wave sleep (SWS) duration and even a slight increase in paradoxical sleep (PS) duration in treated rats. Results on plasma corticosterone concentrations and on glycemia values were inconclusive with respect to the implication of the HPA axis in this study. However, the protective effect of the alphaS1-casein hydrolysate on sleep during exposure to our chronic mild stress conditions may be mediated by modulation of the central adrenergic response.

PMID: 16303212 [PubMed - indexed for MEDLINE]


1: Pharmacol Biochem Behav. 2006 Jul;84(3):517-23. Epub 2006 Aug 8. Links
Ethological comparison of the effects of a bovine alpha s1-casein tryptic hydrolysate and diazepam on the behaviour of rats in two models of anxiety.Violle N, Messaoudi M, Lefranc-Millot C, Desor D, Nejdi A, Demagny B, Schroeder H.
Neurosciences Comportementales, URAFPA, INRA UC12340, INPL-UHP, 54500 Vandoeuvre-lès-Nancy, France.

A bovine alpha s1-casein tryptic hydrolysate was previously demonstrated to display an anxiolytic-like activity in the conditioned defensive burying and in the elevated plus-maze models when i.p. injected. The present study assessed the anxiolytic-like effects of this tryptic hydrolysate after an oral administration in rats faced to the same behavioural situations using diazepam as a reference. In a first experiment, the behavioural effects of the hydrolysate in the conditioned defensive burying test were investigated at doses ranging 5-50 mg/kg. The results showed that the minimal dose required to elicit an anxiolytic-like activity is 15 mg/kg. In a second experiment, the alpha s1-casein tryptic hydrolysate (15 mg/kg, p.o.) was demonstrated to display an anxiolytic-like activity similar to diazepam (3 mg/kg, p.o.) in the conditioned defensive burying test and the elevated plus-maze. However, the ethological analysis of behaviour indicated that this hydrolysate has a different activity compared to diazepam. While diazepam induced a disinhibition state in rats, possibly related to the risk-taking behaviour observed after a benzodiazepine ingestion in humans, the tryptic hydrolysate did not display such a side effect. These results suggest that the mechanism of action of the bovine alpha s1-casein tryptic hydrolysate may differ from that of diazepam.

PMID: 16899284 [PubMed - indexed for MEDLINE]


1: Eur J Clin Nutr. 2007 Apr;61(4):536-41. Epub 2006 Nov 29.
Efficacy of alphas1-casein hydrolysate on stress-related symptoms in women.Kim JH, Desor D, Kim YT, Yoon WJ, Kim KS, Jun JS, Pyun KH, Shim I.
Department of Integrative Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

OBJECTIVE: To examine the effects of alpha (s1)-casein hydrolysate on females with stress-related symptoms. DESIGN: Double-blind, randomized, crossover, placebo-controlled trial. SETTING: The alpha (s1)-casein hydrolysate was manufactured by INGREDIA (Arras, France) and the placebo was manufactured by DIETAROMA (Bourg, France). Study was designed and performed at PROCLAIM (Rennes, France), and the statistical analyses were performed by D Desor (Nancy, France). SUBJECTS: A total of 63 female volunteers suffering from at least one disorder that may be related to stress such as anxiety, sleep problems and general fatigue. INTERVENTIONS: A total of 63 volunteers participated in a double-blind, randomized, crossover, placebo-controlled study. Subjects were randomly allocated to receive either tablets containing alpha (s1)-casein hydrolysate or placebo at the dose of 150 mg/day for 30 days. After a 3 weeks washout period, they were crossed over for a new 30-day period of tablets intake. The outcome measure was a questionnaire including 44 items of symptoms that may be related stress in which the severity of each sign was evaluated using a 10-degree scale. These measures were studied repeatedly at the day of 0, 15 and 30 after the start of each interventional period. RESULTS: The 30-day treatment by alpha (s1)-casein hydrolysate in females with stress-related symptoms reduced their symptoms, particularly in digestion (P<0.01), cardiovascular (P<0.05), intellectual (P<0.01), emotional (P<0.05) and social problems (P<0.05). CONCLUSION: This study showed that a 30-day ingestion of alpha (s1)-casein hydrolysate decreased the stress-related symptoms in females suggesting that this product may be used as an effective functional ingredient alleviating such symptoms. Sponsorship: This study was partially supported by the INGREDIA of France and Neurobiology Research Program from the Korea Ministry of Science and Technology (2004-01757) of Korea.

PMID: 17136040 [PubMed - indexed for MEDLINE]

[Jacovis]

Metagenics also has the following two products that contain Lactium (Casein Tryptic Hydrolysate):

Benesom™
ONE TABLET SUPPLIES:
Casein Tryptic Hydrolysate† 75 mg
Melatonin 1 mg
Passionflower Flower 5.5:1 Extract (Passiflora incarnata) 300 mg

Lumina™
TWO SOFTGELS SUPPLY:
Calories 11
Calories from Fat 11
Total Fat 1 g
Cholesterol <5 mg
L-Theanine 200 mg
Casein Tryptic Hydrolysate† 150 mg
Natural Marine Lipid Concentrate 800 mg
DHA (Docosahexaenoic acid) 400 mg
EPA (Eicosapentaenoic acid) 160 mg

[Jacovis]

The below 'study' has been used to advertise a Lactium® product...

http://www.rilax.inf.....tudy 2006.pdf

SO KEN study:
Efficacy of lactium® on sleep disorders
October2006
Aim :
The target of this clinical investigation was to study the effects of lactium®
intake on sleep disorders.
Protocol
􏰀165 Japanese healthy males and females aged between 25 and 40,
but aware of sleep troubles
􏰀selection of 44 subjects from self evaluation –inclusion criteria :
􏰁PSQI score > 5 and
􏰁HAD score < 10
􏰁2 homogenous groups : lactium®and placebo
􏰀1 capsule a day (150 mg lactium®) during 4 weeks
􏰀4 observation periods in addition to initial screening :
􏰁during the intake period : weeks 0, 2, 4
􏰁after the treatment : week 4+1
􏰀evaluation questionnaires : Pittsburg Sleep Quality Index (PSQI)
Epworth Sleepiness Scale (ESS)

Key points
PSQI
PSQI is a suitable index to evaluate the sleep quality of “poor sleepers”
􏰀lactium® shows a positive effect on almost all the tested items
in whole population
􏰀Nevertheless, some positive results are also observed with placebo.
The placebo effect is a well-known phenomenon especially :
􏰁in psychosomatic troubles like sleep disorders,
􏰁for “expecting people”with severe symptoms.
It is a short-term effect, as confirmed with the poor placebo results at W4+1.
􏰀In whole population, lactium
intake particularly improves :
􏰁sleep duration,
􏰁sleep efficiency.

Key points
􏰀In subjects with a moderate anxiety or depressive profile (HAD-A or HAD-D <7),
the benefits of lactiumare still more noticeable.
Lactiumimproves significantly the :
􏰁sleep quality
􏰁sleep efficiency
􏰁
􏰁sleep disturbances
􏰁daytime dysfunction
􏰁Global PSQI score.
􏰀it is not the case with placebo.
􏰀lactium®decreases sleep troubles, probably via physiologic effects.

Key points
ESS
ESS is a good tool to evaluate alertness or sleepiness during the day
􏰀3 key items of ESS are good indicators of alertness and cognitive
performances :
􏰁sitting in active public place (meeting…),
􏰁sitting and talking to someone
􏰁driving and stopped at a traffic light.
􏰀the intake of lactium®significantly reduces the diurnal sleepiness for 2 of
them, even one week after the treatment.
􏰀lactium®also reduces the sleepiness when being “as a passenger in a car" and “lying down in the afternoon”.

lactium®improves diurnal alterness, probably because it restores night’s quality.

CONCLUSION:
􏰀lactium®decreases the sleep disorders, in particular for people with moderate
anxious/depressive profile
􏰀lactium®progressively restores a good sleep without being soporific
􏰀lactiumhas more a physiological effect, whereas Placebo has a psychological
effect only (especially for expecting people)
􏰀For pathological sleep disorders, lactium®could be helpful but it is not a
sedative drug.
GOOD NIGHTS FOR GOOD DAYS :
Do you fall asleep during the day (meeting, car travel…) ? That probably means that the quality of your
night sleep is not good. If you want to have a good day, have first of all a good night.
Take lactium®and you’ll have Good Nights for Good days…

[NootropicEU]

It is used for dogs and cats.

http://www.petvetcar...___Feliway.html