6 replies to this topic

[anthonyedgar300]

Tolcapone Improves Cognition and Cortical Information Processing in Normal Human


http://www.nature.co...l/1301227a.html

[meursault]

Also seems to have a lot of risks/side effects.

http://www.rxlist.co...lcapone_wcp.htm

[edward]

very interesting
the prefrontal cortex is the site where a lot of the beneficial effects of amphetamines, modafinil and straterra supposedly come from

Tolcapone is rough on the liver though

[edward]

But it does show that a COMT inhibitor specific to certain areas of the brain could be very beneficial to cognition and attention disorders without some of the stimulant side effects... I am sure one could be created with less liver and other problems.

[lynx]

Green Tea extract and Rhodiola are natural COMT inhibitors. Both exert a nootropic effect for me.

[dr_chaos]

looks like genotype specific enhancements are not that far off...

I am sure one could be created with less liver and other problems.

some pharma company is up to do that since comt inhibitors are used for treating parkinsons. i don't remember its name, though.

[dr_chaos]

http://img.orion.fi/...teet/200857.pdf
here we go...
its orion pharma. but their pdf is not really telling something meaningful...