Nice find nameless. Here's the link to the Rotterdam study:
http://jn.nutrition....ull/134/11/3100Some excerpts:
Energy-adjusted intake of phylloquinone was not associated with risk of nonfatal MI, incident CHD (fatal and nonfatal events combined), CHD mortality, and all-cause mortality (Table 2). For menaquinone intake (Table 3) there was an inverse relationship with nonfatal MI in the upper vs. lower tertile after adjustment for confounders, but findings were not statistically significant. Risk of incident CHD, however, was strongly and significantly reduced in the upper tertile of menaquinone intake (RR = 0.59), as were risk of CHD mortality (RR = 0.43) and all-cause mortality (RR = 0.74). Additional adjustment for intake of fiber, vitamin C, vitamin E, and ß-carotene did not change these results.
The upper tertile of menaquinone intake was > 32mcg daily.
Mean intake of phylloquinone intake was similar in categories of aortic calcification (249.2, 249.0, and 245.0 µg/d for mild, moderate, and severe stages, respectively), after adjustment for age, gender, and total energy intake. Menaquinone intake was lower in subjects with severe aortic calcification (25.6 µg/d) than in subjects with moderate or mild calcification (28.6 and 28.8 µg/d, respectively; P = 0.001).
Intake of phylloquinone was not significantly associated with moderate or severe aortic calcification after adjustment for age and gender (model 1) or after further adjustment for confounders. In fully adjusted analysis (model 2), ORs for severe calcification were 0.86 (0.61, 1.22) and 1.03 (0.72, 1.48) in the mid and upper tertiles of phylloquinone, respectively, compared to the lower tertile. Menaquinone intake showed no significant association with moderate calcification (Table 4). For severe calcification, however, a strong inverse relationship with menaquinone intake persisted after adjustment for BMI, smoking, education, diabetes, and intake of alcohol, PUFA, SFA, flavonols, and calcium (Table 4). Additional adjustment for intake of fiber, vitamin C, vitamin E, and ß-carotene did not change these results.
They are looking at really small quantities here and small variations in intake and yet still notice significant impact from menaquinone. One thing is certain: K1 is garbage from a heart disease perspective. The authors don't seem to indicate that there is any significant differences between various forms of menaquinone in terms of effects.
Edited by FunkOdyssey, 17 June 2008 - 08:28 PM.