The implication of this paper are that any means of reducing AGE formation will extend life span: Eating raw foods, or at steamed or boiled, and not fried or grilled foods. Carnosine and Kremezin are possible supplements to his end. I have doubts about Kremezin, which seems to be a form of micronized activated charcoal. Are there other supplements that can be taked with food to inhibit AGE formation?
Conversely, CR would prove useless if AGE's were allowed to proliferate and accumulate.
Am J Pathol. 2008 Jul 3. [Epub ahead of print]
Oral Glycotoxins Determine the Effects of Calorie Restriction on Oxidant Stress, Age-Related Diseases, and Lifespan.Cai W, He JC, Zhu L, Chen X, Zheng F, Striker GE, Vlassara H.
From the Department of Geriatrics,* Division of Experimental Diabetes and Aging, and the Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, New York; and the Departments of Medicine and Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
We previously showed that the content of advanced glycation end products (AGEs) in the diet correlates with serum AGE levels, oxidant stress (OS), organ dysfunction, and lifespan. We now show that the addition of a chemically defined AGE (methyl-glyoxal-BSA) to low-AGE mouse chow increased serum levels of AGEs and OS, demonstrating that dietary AGEs are oxidants that can induce systemic OS. OS predisposes to the development of cardiovascular and chronic kidney diseases; calorie restriction (CR) is the most studied means to decrease OS, increase longevity, and reduce OS-related organ damage in mammals. Because reduction of food intake also decreases oxidant AGE s intake, we asked whether the beneficial effects of CR in mammals are related to the restriction of oxidants or energy. Pair-fed mice were provided either a CR diet or a high-AGE CR diet in which AGEs were elevated by brief heat treatment (CR-high). Old CR-high mice developed high levels of 8-isoprostanes, AGEs, RAGE, and p66(shc), coupled with low AGER1 and GSH/GSSG levels, insulin resistance, marked myocardial and renal fibrosis, and shortened lifespan. In contrast, old CR mice had low OS, p66(shc), RAGE, and AGE levels, but high AGER1 levels, coupled with longer lifespan. Therefore, the beneficial effects of a CR diet may be partly related to reduced oxidant intake, a principal determinant of oxidant status in aging mice, rather than decreased energy intake.
(This paper's abstract was posted to S.L.E last week here)
Edited by maxwatt, 14 July 2008 - 09:02 PM.