• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * - 8 votes

Vinpocetine -- Ditch It


  • Please log in to reply
115 replies to this topic

#91 Climactic

  • Guest
  • 331 posts
  • 54
  • Location:USA

Posted 21 March 2014 - 05:24 AM

Would this be useful to take on amphetamine/stimulant break days?


Vinpocetine is useful everyday, but its effect is more pronounced if you don't take it everyday. Unfortunately its half-life is rather small, such that its main mental effect, if you feel it at all, is gone inside of a couple of hours. I think a proper extended-release version would help, but I haven't seen one in the market. The alternative way to have a longer effect would be to take 10mg 3x daily, which also happens to be the most recommended dose. Personally I take 30mg just once. I can't speak for amphetamine, but I take it with or without armodafinil.

Edited by Climactic, 21 March 2014 - 05:26 AM.

  • like x 1

#92 basicdude

  • Guest
  • 10 posts
  • 3
  • Location:Cali

Posted 21 March 2014 - 05:31 AM

Well I have read a lot of disconcerting things about combining vinpo with stimulants like adderall or focalin so I wasn't sure. Would 10mg be a significant amount to actually interact with the stimulant dose, though?

sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#93 Climactic

  • Guest
  • 331 posts
  • 54
  • Location:USA

Posted 21 March 2014 - 05:41 AM

Well I have read a lot of disconcerting things about combining vinpo with stimulants like adderall or focalin so I wasn't sure. Would 10mg be a significant amount to actually interact with the stimulant dose, though?

I have been taking 30mg vinpocetine with 150mg armodafinil for many months now, without issue. Add to that a lot of caffeine too. Vinpocetine can indeed add to the stimulant effect if they're taken together, but this additive effect is simply gone after a couple of hours. I can't be 100% sure about using it with other stimulants, but I think you're in pretty safe territory if you start off with 10mg vinpocetine with a small dose of the stimulants of interest. It will probably still interact, but so much weakly. Also bear in mind that as your body gets used to the vinpocetine, some tolerance develops and its effect is somewhat diminished. With the combination, sometimes I get a brief feeling of being over-wired, but this to me is better than being under-wired.

Edited by Climactic, 21 March 2014 - 05:45 AM.

  • Dangerous, Irresponsible x 1

#94 sakay

  • Guest
  • 7 posts
  • 3
  • Location:us

Posted 21 March 2014 - 06:06 AM

I agree with climatic I think its ok to follow that
  • like x 1

#95 basicdude

  • Guest
  • 10 posts
  • 3
  • Location:Cali

Posted 21 March 2014 - 06:18 AM

If I continue to take stimulants it would probably be 15mg XR and 10 mg IR. Right now I have started an Adderall Rx but I would consider going back to Focalin.

Edited by basicdude, 21 March 2014 - 06:20 AM.


#96 Climactic

  • Guest
  • 331 posts
  • 54
  • Location:USA

Posted 21 March 2014 - 07:03 AM

If I continue to take stimulants it would probably be 15mg XR and 10 mg IR. Right now I have started an Adderall Rx but I would consider going back to Focalin.

In general, independent of vinpocetine, for long term usage, my naive impression is that methylphenidate and family are safer than amphetamine and family. As an aside, I wonder about the possibility of taking some methylphenidate with my armodafinil. Armodafinil helps very effectively with staying up and not feeling drowsy for 18h a day, but not necessarily with getting actual work done. Finally, of course I would strongly suggest taking days off, at least weekends, for any of these prescription stimulants.

Edited by Climactic, 21 March 2014 - 07:05 AM.

  • Dangerous, Irresponsible x 1

#97 FW900

  • Guest
  • 341 posts
  • 131
  • Location:VMAT2
  • NO

Posted 21 March 2014 - 03:42 PM

If I continue to take stimulants it would probably be 15mg XR and 10 mg IR. Right now I have started an Adderall Rx but I would consider going back to Focalin.

In general, independent of vinpocetine, for long term usage, my naive impression is that methylphenidate and family are safer than amphetamine and family. As an aside, I wonder about the possibility of taking some methylphenidate with my armodafinil. Armodafinil helps very effectively with staying up and not feeling drowsy for 18h a day, but not necessarily with getting actual work done. Finally, of course I would strongly suggest taking days off, at least weekends, for any of these prescription stimulants.


Climactic: Just to let you know, there's many reports on various narcolepsy and idiopathic hypersomnia (now known as Major Somnolence Disorder) forums of people who use this combination (MPH+[ar]modafinil) with no ill effect. I assume it's a very safe combination.
  • like x 1

#98 Brain Teaser

  • Guest
  • 2 posts
  • 3
  • Location:United States

Posted 07 May 2014 - 03:25 PM

Hi all. I stumbled onto this forum as I was doing a google search on vincopetine. Let me start off by saying that cerebella ataxia is in my family, and for the past 7-8 years I have transformed into a shell of my former self.
 
I have been dealt a horrible hand in life, and have been battling illness since my birth.
 
With that said, I spend 100s of dollars every year on supplements to see if any will help. So far, I had the best results with glucosamine and chondriotin, but the side effects are too much too put up with. So I read the benefits of vincopetine and decided to give it a try. The first few days were great- little to no side effects, improved sleep and more energy! But after that I experienced depression, obnoxious abdominal pain, hideous diarrhea, nausea, and ridiculously high blood sugars. Now if a brain supplement didn't raise my blood sugars I'd say it's not doing its job, as anything that increases blood flow, automatically increases the amount of glucose your blood transports. I get that, and if it was only high blood sugars, I'd probably continue taking it, but after I read most of this thread, and the side effects I had experienced, I'm staying away from this!
 
I haven't been diagnosed with ataxia as of yet, I have a neuro appointment soon, but I assume my cerebella is shrinking and I have great difficulty walking and remaining steady. My speech is getting erratic, and sometimes I have brain fog.
 
Does anybody know of any supplement that might have a chance of helping? Thanks.


#99 Nootmeup

  • Guest
  • 35 posts
  • 2
  • Location:Los Angeles
  • NO

Posted 10 July 2014 - 09:59 AM

!!!!!!NO NOOT LEFT BEHIND!!!!!
So that's it? .....We just abandon vinpocetine............. Forever. I think here is an abundance of over-dramatization in this thread.I have read plenty of studies and testimonials where it has worked dramatically as a vasodilator for memory and blood flow;superior to that of ginkgo and works in about 1/10 the time.
I noticed my memory enhanced from it. The post about depression in this thread make me tempted to stop it for a while and see how it effects me....as the last few months have not been the greatest, maybe circumstantial tho,
Forgive my ignorance as I am very time deprived, can anyone explain it's effects on NMDA. Does Vino inhibit it?...... If so.... It could be a good thing for a person with my brain chemistry (ADD) as most ADD and ADHD drugs inhibit NMDA anyways, and I briefly skimmed over the post that's said it inhibits DA. If it is in fact vinopoctine is a dopamine antagonist I will surely drop it and just use Ginkgo. Thanks ahead of time guys and keep on being brilliant.

#100 Climactic

  • Guest
  • 331 posts
  • 54
  • Location:USA

Posted 10 July 2014 - 12:53 PM

can anyone explain it's effects on NMDA. Does Vino inhibit it?......

 

Vinpocetine protects a bit from both dopamine oxidation and NMDA excitotoxicity. There is no significant effect either way. It has a short half-life. I continue to use 30 mg vinpocetine daily without issue.


Edited by Climactic, 10 July 2014 - 12:53 PM.


#101 kilomonk

  • Guest
  • 6 posts
  • 2
  • Location:Florida, USA
  • NO

Posted 14 July 2014 - 03:48 PM

I'm an occasional user if vinpocetine. I seem to react to lower doses of most substances and typically take 5mg. doses for clarity when not taking other supplements/chemicals. I've noticed repeatedly that I can hold my breath longer while swimming underwater. At first I thought this was just an anomaly but after realizing that vinpocetine was the only substance I had taken on the day I first realized this (about an 90 minutes prior), I repeated the outcome several more times. I can double the distance I can swim underwater as measured in a freshwater pool. This seems to be a good thing - enjoyable anyway - but I don't know if doing such allows for any buildup of toxins and I was going to mention it to a freediving acquaintance but decided against it. No danger in the six foot deep pool I swim in. Just wondered if anyone else had experienced this or anything similar?



#102 john1960

  • Guest
  • 42 posts
  • 6
  • Location:USA

Posted 14 July 2015 - 01:14 AM

Bumping this thread.

 

So I have been taking vinpocetine for around 5 weeks now to help with tinnitus/other hearing problems. I take it 10mg 3xday w/ meals.

 

Since reading about this thread, I dont know if its a placebo effect, but I feel like my mood/cognitive function is being negatively effected a bit. At the same time, it could very well be from other things. Kinda wish I didnt stumble on this thread, but I did. The original post did seem to make a legitimate point.

 

Anyways, what is the consensus on the original post? Is vinpo actually bad for the brain? Or am I ok to take it as I have been? (I believe Im noticing a positive effect with my ears)



#103 John Hess

  • Guest
  • 7 posts
  • 2
  • Location:Florida
  • NO

Posted 02 August 2015 - 01:30 AM

Bumping this thread.

So I have been taking vinpocetine for around 5 weeks now to help with tinnitus/other hearing problems. I take it 10mg 3xday w/ meals.

Since reading about this thread, I dont know if its a placebo effect, but I feel like my mood/cognitive function is being negatively effected a bit. At the same time, it could very well be from other things. Kinda wish I didnt stumble on this thread, but I did. The original post did seem to make a legitimate point.

Anyways, what is the consensus on the original post? Is vinpo actually bad for the brain? Or am I ok to take it as I have been? (I believe Im noticing a positive effect with my ears)


My impression is that it should be relatively safe, and hopefully beneficial. Those first studies involved animals so they do not apply to human use whatsoever. I think it's safe to say that the OP was jumping to conclusions without proper references to actual human studies.

Attached Files



#104 Sasha_

  • Guest
  • 77 posts
  • 3
  • Location:Paris, France

Posted 02 August 2015 - 03:19 PM

I also think it is safe, and use it sometimes alone but mostly with centrophenoxine and idebenone to give me a good brain/mood boost.

I now use 5mg caps, to give me the choice of a smaller dosage if I want it.

In the past I did notice feeling transiently a bit down/depressed following a 15mg dose (either single dose or repeated once more in the day).

If you can afford it I think Pycnogenol is a better choice for both tinnitus relief and plenty other cognitive/health benefits ! http://www.ncbi.nlm....7?dopt=Abstract



#105 outofservice

  • Guest
  • 7 posts
  • 2
  • Location:Florida
  • NO

Posted 13 January 2016 - 02:19 AM

Can you take Vinpocetine and Lamotrigine together?    The Lamotrigine is for Bipolar Depression Type II.

 

 

I'm also taking Huperzine A, Acetyl-L-Carnitine, Macuna Pruriens (25% L-Dopa) and Alpha GPC.



#106 Flex

  • Guest
  • 1,629 posts
  • 149
  • Location:EU

Posted 18 January 2016 - 10:42 PM

Can you take Vinpocetine and Lamotrigine together?    The Lamotrigine is for Bipolar Depression Type II.

 

 

I'm also taking Huperzine A, Acetyl-L-Carnitine, Macuna Pruriens (25% L-Dopa) and Alpha GPC.

 

Better ask Your Doc. Even if there are some bad Docs, it would be still safer.

 

I mean even if its harmful You wouldnt allways feel any ill effect. In this case YOu would only feel a cumulative effect.

 

 


Edited by Flex, 18 January 2016 - 10:42 PM.


#107 jroseland

  • Guest
  • 1,100 posts
  • 161
  • Location:Europe

Posted 23 February 2017 - 08:16 AM

There was a guy years ago named Robert Monroe who founded the famous "Monroe Insitute." It is alledged that he was consulted at one point by the CIA for his insights into enhanced cognative abilities and extra sensory abilities. He was the inventor of the patented "Hemi-Sync" sound technology.
 

This guy!



#108 gamesguru

  • Guest
  • 3,281 posts
  • 399
  • Location:coffeelake.intel.int

Posted 23 February 2017 - 10:33 PM

Is this the guy who ate periwinckle with breakfast as a kid?  He looks real charming tho.  Might seriously have to give vinpocetine a second chance



#109 Climactic

  • Guest
  • 331 posts
  • 54
  • Location:USA

Posted 25 February 2017 - 10:28 PM

FWIW, I changed my vinpocetine dosing from 30mg x1 to 10mg x2 for greater stability and safety. I have been reasonably happy with the new dose.



#110 Rugby123

  • Guest
  • 1 posts
  • 2
  • Location:Uruguay

Posted 06 September 2017 - 04:01 PM

Ditch this supplement, I have been taken it for a few days and if anything it gives me anxiety and does seems like it reduces dopamine.

#111 John250

  • Guest
  • 1,451 posts
  • 109
  • Location:Temecula
  • NO

Posted 30 January 2018 - 06:17 AM

What about it’s blood thinning and anti clotting factors. That’s why I started using it but if it only helps a little with that then maybe it’s time to ditch it.

#112 nooguyz

  • Guest
  • 83 posts
  • -1
  • Location:Europe

Posted 06 March 2018 - 05:18 PM

!!!!!!NO NOOT LEFT BEHIND!!!!!
So that's it? .....We just abandon vinpocetine............. Forever. I think here is an abundance of over-dramatization in this thread.I have read plenty of studies and testimonials where it has worked dramatically as a vasodilator for memory and blood flow;superior to that of ginkgo and works in about 1/10 the time.
I noticed my memory enhanced from it. The post about depression in this thread make me tempted to stop it for a while and see how it effects me....as the last few months have not been the greatest, maybe circumstantial tho,
Forgive my ignorance as I am very time deprived, can anyone explain it's effects on NMDA. Does Vino inhibit it?...... If so.... It could be a good thing for a person with my brain chemistry (ADD) as most ADD and ADHD drugs inhibit NMDA anyways, and I briefly skimmed over the post that's said it inhibits DA. If it is in fact vinopoctine is a dopamine antagonist I will surely drop it and just use Ginkgo. Thanks ahead of time guys and keep on being brilliant.

Well, I also would consider myself having ADHD, or at least low dopamine and high MAO activity, so I don't think this supplement is for me despite its insane boost for memory (which I would love to have), mood uplift and lift in energy. Unfortunately, though... I was really excited about it until I found this thread. I think I'll stick to other supplements, but I don't think there are many that improve memory and give other benefits like this one, or at least I have not come up with such as of yet. I still have plenty to look at though.



#113 John250

  • Guest
  • 1,451 posts
  • 109
  • Location:Temecula
  • NO

Posted 19 June 2018 - 03:39 PM

I have come to the conclusion that vinpocetine should be eradicated from our supplement stashes. This is due in light of evidence brought about by "dopamine" who is now posting more frequently on our boards.


This is taken from M & M, a thread started by dopamine.



Then I noticed through researching studies that vinpocetine has a negative impact on the NMDA receptors and the AMPA receptors. These are two very important receptor systems that substances claimed of being nootropics should elicit a positive affect on or no affect at all. Here are two studies which show vinpocetine have a negative affect on them, I THINK!



AND THIS ONE FOR AMPA




What do you all think? Dopamine, what are your thoughts on the studies I brought up and vinpocetine as a whole for its use in healthy individuals?


edit: I would like to add that I am down to 25mg of tramadol twice daily now. I was doing this just for health (tapering down to get off completely) then yesterday I found out that tramadol is an NMDA antagonist!!!!! No wonder why my memory has been so screwy as of late! Within a few days, I will be off completely. I also got a script for adderall last week, yet I only took a couple pills and decided against taking them. I figure I'd get BETTER, HEALTHIER results by just going about it the NATURAL, HEALTHY way.... This is of course in regards to combating my diagnosed inattentive-type ADD without hyperactivity and most importantly having phenomenal cognitive capabilities indefinitely throughout my immortal lifetime... http://www.imminst.o..._DIR#/smile.gif


Would microdosing Vinpocetine negate those sides?

https://www.ncbi.nlm...ubmed/11478921/

“The parallel determination of the released and retained catecholamine concentrations revealed that vinpocetine increases DOPAC release at the expense of internal DA in a dose-dependent manner (low microM range). In contrast to vinpocetine, the selective MAO-A inhibitor, clorgyline, increases DA and decreases DOPAC formation.”

#114 BioHacker=Life

  • Guest
  • 249 posts
  • -7
  • Location:USA

Posted 21 June 2018 - 09:52 AM

So I find it's a mild mental stimulant and helps me process info faster. I take 40 mg which is the studied dose and notice a positive effects after about an hour. Not sure why you guys are dosing 5 mg that's well below the studies on healthy adults and those with issues. 



#115 John250

  • Guest
  • 1,451 posts
  • 109
  • Location:Temecula
  • NO

Posted 02 July 2018 - 08:16 PM

If vinpocetine inhibits VMAT2 then what would it’s role with amphetamines be since I believe amphetamines are also VMAT2 inhibitors? Would it make them weaker or stronger?

Edited by John250, 02 July 2018 - 08:20 PM.


sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#116 jroseland

  • Guest
  • 1,100 posts
  • 161
  • Location:Europe

Posted 22 January 2021 - 12:41 PM

It's another Nootropic that has a range of anti-aging effects to maintain a mind that has four, five, six or more decades of wear and tear on it but has limited value to otherwise healthy people or Biohackers looking to improve performance. Why Vinpocetine is a "negative Nootropic" for many Biohackers...
 
1*H_7J6fJ_uqrSEwbfeSOemw.png
 
 

  • unsure x 1




0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users