This post comes after posting about the risks of deprenyl. I _still_ don't quite understand what explicit nootropics can't be mixed with it or what medications/supplements/vitamins/etc. I did post asking about that a week ago and didn't get much of a response. If there were a resource I could just look up here on the forums it would circumvent all the guess work.
Major Drug-Food Interaction selegiline (Major Drug-Food)GENERALLY AVOID: Foods that contain large amounts of tyramine may precipitate a hypertensive crisis in patients treated with monoamine oxidase inhibitors (MAOIs). The mechanism is inhibition of MAO-A, the enzyme responsible for metabolizing exogenous amines such as tyramine in the gut and preventing them from being absorbed intact. Once absorbed, tyramine is metabolized to octopamine, a substance that is believed to displace norepinephrine from storage granules. Although selegiline is considered a selective inhibitor of MAO-B, the selectivity may not be absolute even at recommended dosages. Rare cases of hypertensive reactions associated with ingestion of tyramine-containing foods have been reported in patients taking the recommended daily oral dose of selegiline. Data for transdermal selegiline indicate that the 6 mg/24 hour dosage may be given safely without dietary restrictions. However, limited data are available for higher dosages.
MANAGEMENT: Patients treated with oral selegiline and transdermal selegiline (greater than 6 mg/24 hour) should preferably avoid consumption of products that contain large amounts of amines and protein foods in which aging or breakdown of protein is used to increase flavor. These foods include cheese (particularly strong, aged or processed cheeses), sour cream, wine (particularly red wine), champagne, beer, pickled herring, anchovies, caviar, shrimp paste, liver (particularly chicken liver), dry sausage, salamis, figs, raisins, bananas, avocados, chocolate, soy sauce, bean curd, sauerkraut, yogurt, papaya products, meat tenderizers, fava bean pods, protein extracts, yeast extracts, and dietary supplements. Caffeine may also precipitate hypertensive crisis so its intake should be minimized as well. At least 14 days should elapse following discontinuation of selegiline therapy before these foods may be consumed. Specially designed reference materials and dietary consultation are recommended so that an appropriate and safe diet can be planned. Patients should also be advised to promptly seek medical attention if they experience potential signs and symptoms of a hypertensive crisis such as severe headache, visual disturbances, difficulty thinking, stupor or coma, seizures, chest pain, unexplained nausea or vomiting, and stroke-like symptoms. The recommended dosages of selegiline should not be exceeded, as it can increase the risk of nonselective MAO inhibition and a hypertensive crisis.
Major Interaction 5-HTP, 5-hydroxytryptophan, Actiq, Acutrim 16 Hour, Acutrim II, Maximum Strength, Acutrim Late Day, Adapin, Adipex-P, Adipost, Afrinol, Ah-Chew D, Aldomet, Alfenta, alfentanil, Alphagan, Alphagan P, Amidate, amitriptyline, amoxapine, amphetamine, Amrix, Anafranil, Anorex-SR, Appecon, apraclonidine ophthalmic, Aramine, Asendin, atomoxetine, Aventyl HCl, Babee Cof, Balminil DM, Balminil DM Pour Enfants, Balminil DM Sans Sucrose, Benadryl for the Family Dry Forte, Benylin, Benylin Adult Formula, Benylin DM, Benylin DM Pediatric, Benylin Dry Coughs, Benylin Pediatric, benzphetamine, Bisolvon Dry, Bisolvon Dry Junior, Bontril PDM, Bontril Slow Release, Brevital Sodium, brimonidine ophthalmic, Buckley's Mixture Cough Suppressant, Buckleys Mixture, Budeprion SR, Budeprion XL, buPROPion, buPROPion 24 hour extended release, buPROPion extended release, BuSpar, BuSpar Dividose, busPIRone, Calmylin, carbamazepine, carbamazepine extended release, Carbatrol, carbetapentane, Celexa, Cenafed, Chem Mart Tramadol, Chlor Trimeton Nasal Decongestant, citalopram, clomiPRAMINE, Compound 374, Concerta, Contac 12-Hour, Contac Cold, Contac Cough, Control, Cough Syrup DM, Covonia Bronchial Balsam, Creo-Terpin, Creomulsion, Creomulsion Children, cyclobenzaprine, cyclobenzaprine extended release, Cymbalta, D.H.E. 45, Darvon, Darvon-N, Daytrana, Decofed, Decofed Liquid, Delsym, Delsym 12 Hour Cough Relief, Delsym 12 Hour Cough Relief for Children & Adults, Demerol HCl, desflurane, desipramine, Desoxyn, Desoxyn Gradumet, Despec-SF, desvenlafaxine, Desyrel, Desyrel Dividose, DexAlone, Dexatrim, Dexatrim Caffeine Free, Dexedrine, Dexedrine Spansule, dexfenfluramine, Dexi-Tuss, dexmethylphenidate, dexmethylphenidate extended release, dextroamphetamine, dextroamphetamine extended release, dextromethorphan, dextromethorphan extended release, Dextromethorphan HBr Adult Formula, Dextrostat, Didrex, diethylpropion, diethylpropion extended release, dihydroergotamine, dihydroergotamine nasal, Dimetapp 12-Hour Non-Drowsy Extentabs, Dimetapp Children's Cold & Allergy, Dimetapp Cold Cough & Flu Day & Night Liquid Caps, Dimetapp Cold Drops, Dimetapp Decongestant, Dimetapp Infant Drops, Diprivan, Diskets, Dolophine, DOPamine, Dopram, doxapram, doxepin, doxepin topical, Dristan DM, Drixoral Decongestant Non-Drowsy, Drixoral Non-Drowsy, Dromadol SR, Dromadol XL, droperidol, Dry Cough, duloxetine, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Effexor, Effexor XR, Efidac, Elavil, Elixsure Cough, Elixsure Decongestant, Empro, Endep, enflurane, Entex, ephedra, ephedrine, Epitol, Equetro, Ergomar, ergonovine, ergotamine, Ergotrate Maleate, escitalopram, Ethrane, etomidate, Fastin, fenfluramine, fentanyl, fentanyl topical, Fentora, Fexmid, Flexeril, Fluothane, fluoxetine, fluoxetine extended release, fluvoxamine, fluvoxamine extended release, Focalin, Focalin XR, Forane, furazolidone, Furoxone, Genaphed, GenRx Tramadol, halothane, Hold DM, hypericum perforatum, imipramine, imipramine pamoate, Inapsine, Intropin, Ionamin, Ionsys, Iopidine, isocarboxazid, isoflurane, isometheptene mucate, Jack & Jill Thin Strips Cough, Ketalar, ketamine, Kid Kare Drops, Kutapressin, l-tryptophan, Larapam SR, Lexapro, lisdexamfetamine, liver derivative complex, Lloydspharmacy Dry Adult Cough, Ludiomil, Lusonal, Luvox, Luvox CR, ma huang, maprotiline, Marplan, Matulane, Mazanor, mazindol, Mega-Trim, Melfiat, meperidine, mephentermine, Meridia, Metadate CD, Metadate ER, metaraminol, methadone, Methadose, methamphetamine, methamphetamine extended release, methohexital, methoxyflurane, methyldopa, Methylin, Methylin ER, methylphenidate, methylphenidate 24 hour extended release, methylphenidate extended release, methysergide maleate, Migranal, mirtazapine, Myfedrine, Nardil, nasofed, Nasop, Nasop12, nefazodone, Neo-Synephrine, Neocitran Thin Strips Cough, nitrous oxide, Norpramin, nortriptyline, Novahistine DM, Nucosef DM, Obephen, Obezine, Oby-Cap, Oby-Trim, oxcarbazepine, Pamelor, Panshape M, Parnate, paroxetine, paroxetine extended release, paroxetine mesylate, Paxil, Paxil CR, Pedia Relief, Pediacare, Pediacare Drops, Penthrane, Pentothal, Pertussin CS Childrens, Pertussin DM, Pertussin ES, Pexeva, Phendiet, Phendiet-105, phendimetrazine, phendimetrazine extended release, phenelzine, Phentercot, phentermine, phentermine hydrochloride, phentermine hydrochloride extended release, phentermine resin extended release, Phentride, Phenyl-T, Phenyldrine, phenylephrine, phenylephrine extended release, phenylpropanolamine, Plegine, Pondimin, PP-Cap, Prelu-2, Pristiq, Pro-Fast HS, Pro-Fast SA, Pro-Fast SR, procarbazine, Propagest, Propan, propofol, propoxyphene, propoxyphene hydrochloride, propoxyphene napsylate, protriptyline, Prozac, Prozac Weekly, Prudoxin, pseudoephedrine, pseudoephedrine extended release, Rapiflux, Redux, Remeron, Remeron SolTab, remifentanil, Rhindecon, Ridafed, Ritalin, Ritalin LA, Ritalin-SR, Robafen Cough Liquidgels, Robafen Pediatric Cough & Cold, Robitussin Cough Calmers, Robitussin CoughGels, Robitussin Dry Cough, Robitussin DX Cough Control, Robitussin DX Cough Control Forte, Robitussin DX Dry Cough Forte, Robitussin Honey Cough, Robitussin Junior Persistent Cough, Robitussin Maximum Strength, Robitussin Pediatric Cough Suppressant, Robitussin Soft Pastilles, Sanorex, Sansert, Sarafem, Scot-Tussin Diabetic, Scot-Tussin DM Cough Chasers, Selfemra, sertraline, Serzone, Seudotabs, sevoflurane, sibutramine, Silfedrine, Silphen DM, Sinequan, Sojourn, solotuss, St. John's wort, St. Joseph Cough Suppressant, Statobex, Strattera, Strepsils Cough, Strepsils Cough Relief, Sublimaze, Sucrets DM Cough, Sudafed, Sudafed 12-Hour, Sudafed 24-Hour, Sudafed Child Nasal Decongestant, Sudafed PE, Sudafed PE Extra Strength, Sudafed PE Quick Dissolve, Sudodrin, SudoGest, SudoGest 12 Hour, Sudogest PE, Sudrine, Sufenta, sufentanil, Superfed, Suphedrin, Suprane, Surmontil, T-Diet, Tegretol, Tegretol XR, Tenuate, Tenuate Dospan, Teramine, Teramine ER, Terrell, Terry White Chemists Tramadol, Theraflu Thin Strips Cough, thiopental, Tofranil, Tofranil-PM, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, tranylcypromine, traZODONE, Triaminic A.M., Triaminic DM, Triaminic Infant Drops, Triaminic Long Acting Cough, Triaminic Long Acting Cough(obs), Triaminic Softchew, Triaminic Softchews Allergy Congestion, Triaminic Thin Strips Cold, Triaminic Thin Strips Cough, Triaminic Thin Strips Infant Decongestant, Triaminic Thin Strips Nasal Congestion, Triaminic Thin Strips Nasal Congestion(obsolete), Triaminic Toddler Congestion Thin Strips, Triaminic Toddler Congestion Thin Strips(obsolete), Trileptal, trimipramine, Tryptan, tryptophan, Tussin Pediatric, Tussinol for Dry Coughs, Tylenol Simply Cough, Tylenol Simply Stuffy, Ultane, Ultane P.E.N., Ultiva, Ultram, Ultram ER, Unifed, Vanatrip, venlafaxine, venlafaxine extended release, Vicks 44 Cough Medicine, Vicks 44 Cough Relief, Vicks Formula 44, Vicks Formula 44 for Dry Coughs, Vivactil, Vyvanse, Wellbutrin, Wellbutrin SR, Wellbutrin XL, Westrim, Westrim LA, Wyamine Sulfate Injection, Zamadol, Zamadol 24hr, Zamadol Melt, Zamadol SR, Zantryl, Zoloft, Zonalon, Zyban, Zyban Advantage Pack, Zydol, Zydol SR, Zydol XL
Moderate Interaction
12 Hour Nasal, 12 Hour Nasal Decongestant, 4-Way, 4-Way Menthol, Accuneb, acetoHEXAMIDE, Actibine, Adrenalin, Afrin, Afrin 4 Hour Extra Moisturizing, Afrin All Night NoDrip, Afrin Extra Moisturizing, Afrin Nasal Sinus, Afrin No Drip Severe Congestion, Afrin No Drip Sinus, Afrin NoDrip Extra Moisturizing, Afrin Pump Mist, Afrin Severe Congestion, Afrin Severe Congestion NoDrip, Airet, AK-Con, AK-Dilate, AK-Nefrin, Albalon, albuterol, albuterol extended release, Allerest 12 Hour Nasal Spray, Allerest Eye Drops, Allersol, Altafrin, Altazine, Alupent, Amaryl, Ana-Guard, Antabuse, Anu-Med, Anusert Ointment, Aphrodyne, Apidra, Apidra OptiClik Cartridge, arformoterol, Asthmahaler, Asthmanefrin, Aygestin, bitolterol, Brethaire, Brethine, Bricanyl, Bronchial Mist with Pump, Bronitin, Bronkaid Mist, Bronkometer, Brovana, Camila, chlorproPAMIDE, Clarine, Clear Eyes, clonazepam, Dayto-Himbin, Degest 2, DepoDur, deserpidine, desogestrel, DiaBeta, Diabinese, disulfiram, DOBUTamine, Dobutrex, Dopar, Duramist Plus, Duration, Dymelor, ephedrine nasal, Epi EZ Pen, Epifrin, Epinal, epinephrine, epinephrine borate ophthalmic, epinephrine ophthalmic, EpiPen 2-Pak, EpiPen Auto-Injector, EpiPen JR 2-Pak, EpiPen JR Auto-Injector, Eppy/N, Erex, Errin, Estinyl, Estivin II, ethinyl estradiol, EXUBERA, EXUBERA Combination Pack 12, EXUBERA Combination Pack 15, EXUBERA Kit, Eye-Sine, Foradil Aerolizer, formoterol, Formulation R, Four-Way Nasal Spray, Genasal, Geneye Extra, Geneyes, Glaucon, glimepiride, glipiZIDE, glipiZIDE extended release, GlipiZIDE XL, Glucotrol, Glucotrol XL, glyBURIDE, glyBURIDE micronized, Glynase PresTab, guanadrel, guanethidine, Harmonyl, Hemorid, Hemorrhoidal, Hemorrhoidal Cooling Gel, Hemorrhoidal Ointment, Humalog, Humalog Cartridge, Humalog KwikPen, Humalog Pen, Humulin L, Humulin N, Humulin N Pen, Humulin R, Humulin R (Concentrated), Humulin U, Hylorel, Iletin II Lente Pork, Iletin II NPH Pork, Iletin II Regular Pork, Iletin Lente, Iletin NPH, Iletin Regular, insulin, insulin analog, insulin aspart, insulin aspart protamine, insulin detemir, insulin glargine, insulin glulisine, insulin inhalation, rapid acting, insulin isophane, Insulin Lente Pork, insulin lispro, insulin lispro protamine, Insulin Purified NPH Pork, Insulin Purified Regular Pork, insulin regular, insulin zinc, insulin zinc extended, insulin, lente, insulin, NPH, insulin, ultralente, Ismelin, isoetharine, isoproterenol, Isopto Frin, Isuprel HCl, Isuprel Mistometer, Jolivette, Klonopin, Klonopin Wafer, L-desoxyephedrine nasal, Lantus, Lantus OptiClik Cartridge, Lantus Solostar Pen, Larodopa, Lente insulin, levalbuterol, Levemir, Levemir FlexPen, Levemir InnoLet, Levemir PenFill, levmetamfetamine nasal, levodopa, levonordefrin, levonorgestrel, Levophed Bitartrate, linezolid, Little Noses Decongestant, Maxair, Maxair Autohaler, Mederek, Medihaler-Epi, Medihaler-Iso, mestranol, Metaprel, metaproterenol, methoxamine, metoclopramide, Micronase, Micronefrin, midodrine, Mirena, morphine liposomal, Mucinex Full Force, Mucinex Moisture Smart, Murine Plus, Mydfrin, Nafazair, naphazoline nasal, naphazoline ophthalmic, Naphcon, Naphcon Forte, nateglinide, Neo-Synephrine 12 Hour, Neo-Synephrine 12 Hour Extra Moisturizing, Neo-Synephrine Extra Strength Nasal, Neo-Synephrine Mild Nasal, Neo-Synephrine Nasal, Neo-Synephrine Ophthalmic, Neofrin, Nephron, Nexavar, Nor-QD, Nora-Be, norepinephrine, norethindrone, norethindrone acetate, norgestimate, norgestrel, Norplant System, Nostril Nasal Decongestant, Nostrilla, Novolin L, Novolin N, Novolin N Innolet, Novolin N PenFill, Novolin R, Novolin R Innolet, Novolin R PenFill, NovoLog, NovoLog FlexPen, NovoLog PenFill, NPH insulin, NRS Nasal, NTZ Long Acting Nasal, Ocu-Phrin, Ocu-Zoline, Ocuclear, Opti-Clear, Optigene 3, Orinase, Ortho Micronor, Orvaten, Otrivin, Ovrette, Oxyfrin, Oxymeta-12, oxymetazoline nasal, oxymetazoline ophthalmic, Perforomist, Phenoptic, phenylephrine nasal, phenylephrine ophthalmic, phenylephrine topical, pirbuterol, Plan B, Prandin, Prefrin, Prep-Hem, Preparation H, Preparation H Cooling Gel, Preparation H Suppositories, Pretz-D, Primatene Mist Inhaler, Primatene Mist Suspension, Privine, ProAir HFA, ProAmatine, Prompt Relief, propylhexedrine nasal, protamine zinc insulin, Proventil, Proventil HFA, Proventil Repetabs, racepinephrine, Rauwolfemms, Rauwolfia 1X, rauwolfia serpentina, Redness Relief, Reglan, regular insulin, Relief, ReliOn/Novolin N, ReliOn/Novolin R, repaglinide, reserpine, Respirol, Rhinall, ritodrine, S2 Inhalant, salmeterol, Serevent, Serevent Diskus, Sinarest Nasal, Sinex Long-Acting, Sinex Nasal Spray, Sinex Ultra Fine Mist, sorafenib, Starlix, Sus-Phrine Injection, terbutaline, Testomar, tetrahydrozoline nasal, tetrahydrozoline ophthalmic, Tetrasine, Tetrasine EX, Thybine, Tol-Tab, TOLAZamide, TOLBUTamide, Tolinase, Tornalate, Twice-A-Day, Twinject Auto-Injector, Twinject Auto-Injector Two Pack, Tyzine Nasal, Ultralente insulin, VasoClear, Vasocon, Vasoxyl, Velosulin BR, Ventolin, Ventolin HFA, Ventolin Nebules, Ventolin Rotacaps, Vicks Vapor Inhaler, Visine, Visine Advanced Relief(obsolete), Visine Extra, Visine L.R., Visine Long Lasting, Vision Clear, Vision Eye, Volmax, VoSpire ER, Xopenex, Xopenex Concentrate, Xopenex HFA, xylometazoline nasal, Yocon, Yohimar, Yohimbe, yohimbine, Yohimex, Yoman, Yovital, Yutopar, Zicam Extreme Congestion Relief, Zicam Sinus Relief, Zyvox
Minor Interaction
Accupril, acebutolol, Aceon, Adalat, Adalat CC, Afeditab CR, Aldactone, alfuzosin, alfuzosin extended release, Altace, amiloride, amlodipine, amyl nitrite, Apresoline, Aquacot, Aquatensen, Aquazide H, Arfonad, Atacand, atenolol, Avapro, benazepril, bendroflumethiazide, Benicar, benzthiazide, bepridil, Betapace, Betapace AF, Betapace AF(obsolete), betaxolol, bisoprolol, Blocadren, Brevibloc, bumetanide, Bumex, Calan, Calan SR, candesartan, Capoten, captopril, Cardene, Cardene IV, Cardene SR, Cardizem, Cardizem CD, Cardizem LA, Cardizem Monovial, Cardizem SR, Cardura, Cardura XL, Carduran, Carozide, carteolol, Cartia XT, Cartrol, carvedilol, carvedilol extended release, Cascor, Catapres, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3, chlorothiazide, chlorthalidone, clonidine, clonidine topical, Coreg, Coreg CR, Corgard, Corlopam, Covera-HS, Cozaar, cyclandelate, Cyclospasmol, Demadex, Demadex I.V., Deponit, Diaqua, Diaqua-2, diazoxide, Dibenzyline, Dilacor XR, Dilatrate-SR, Diltia XT, diltiazem, diltiazem 24 hour extended release, diltiazem extended release, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, Diovan, Diucardin, Diurese, Diuril, Diuril Sodium, Doxadura, doxazosin, doxazosin extended release, Duraclon, Dynacirc, Dynacirc CR, Dyrenium, Edecrin, Edecrin Sodium, enalapril, enalaprilat, Enduron, eprosartan, Esidrix, esmolol, ethacrynic acid, Ethaquin, Ethatab, ethaverine, Ethavex-100, Exna, Ezide, felodipine, felodipine extended release, fenoldopam, fosinopril, furosemide, guanabenz, guanfacine, HCTZ, hydrALAZINE, Hydro Par, hydrochlorothiazide, HydroDIURIL, hydroflumethiazide, Hygroton, Hyperstat, Hytrin, Imdur, indapamide, Inderal, Inderal LA, InnoPran XL, Inversine, irbesartan, ISDN, ISMO, Ismotic PB, Isochron, Isoptin, Isoptin I.V., Isoptin SR, Isordil, Isordil Tembids, Isordil Titradose, isosorbide, isosorbide dinitrate, isosorbide dinitrate extended release, isosorbide mononitrate, isosorbide mononitrate extended release, Isovex, isoxsuprine, isradipine, isradipine extended release, Kerlone, labetalol, Lasix, Levatol, lisinopril, Lo-Aqua, Loniten, Lopressor, Loqua, losartan, Lotensin, Lozol, mannitol, Mavik, mecamylamine, Metahydrin, methyclothiazide, metolazone, metoprolol, metoprolol extended release, metoprolol succinate, Metoprolol Succinate ER, metoprolol tartrate, Micardis, Microzide, Midamor, Minipress, Minitran, minoxidil, moexipril, Monoket, Monopril, Mykrox, nadolol, Naqua, Naturetin-10, Naturetin-5, niCARdipine, niCARdipine extended release, Nifediac CC, Nifedical XL, NIFEdipine, NIFEdipine extended release, nimodipine, Nimotop, nisoldipine, Nitrek, Nitro TD Patch-A, Nitro-Bid, Nitro-Bid IV, Nitro-Dur, Nitro-Par, Nitro-Time, Nitrocot, Nitrodisc, Nitrogard, nitroglycerin, Nitroglyn E-R, Nitrol, Nitrol Appli-Kit, Nitrolingual, Nitrong, Nitropress, nitroprusside, Nitroquick, Nitrostat, Normodyne, Norvasc, NTG, olmesartan, Oretic, Osmitrol, Papacon, papaverine, papaverine extended release, Para-Time S. R., Pavabid Plateau, Pavacot, Pavagen, penbutolol, perindopril, phenoxybenzamine, phentolamine, pindolol, Plendil, polythiazide, prazosin, Prinivil, Procardia, Procardia XL, Proglycem, propranolol, propranolol extended release, quinapril, ramipril, Renese, Resectisol, Saluron, Sectral, sodium nitroprusside, Sorbitrate, Sorine, sotalol, Sotalol Hydrochloride AF, Sotalol Hydrochloride AF(obsolete), spironolactone, Sular, Taztia XT, telmisartan, Tenex, Tenormin, terazosin, Teveten, Thalitone, Tiazac, timolol, tolazoline, Toprol-XL, torsemide, Trandate, trandolapril, triamterene, trichlormethiazide, Tridil, trimethaphan camsylate, Univasc, urea, Ureaphil, Uroxatral, valsartan, Vascor, Vasodilan, Vasotec, verapamil, verapamil 24 hour extended release, verapamil extended release, Verelan, Verelan PM, Visken, Wytensin, Zaroxolyn, Zebeta, Zestril
Here you go
Just go to
Drugs.com and check your interactions.
Edited by revnik, 12 August 2008 - 10:07 PM.
