From Sunday's 60 Mins:
http://video.msn.com...:-1:ind:1:ff:8A
Posted 08 October 2008 - 03:56 PM
Edited by Anthony_Loera, 08 October 2008 - 04:02 PM.
Posted 08 October 2008 - 06:14 PM
Posted 08 October 2008 - 07:12 PM
Where/how can we get this?
Posted 09 October 2008 - 05:28 AM
Posted 09 October 2008 - 05:48 AM
Where/how can we get this?
Several of us have been "mixing our own" for over a year now, as per the recipes in the Maximizing Resveratrol Effectiveness thread. Milk, milk protein, HPMC or Lecithin and other recipes seem to be effective. My favorite is mixing reveratrol powder into a whey protein drink. Several samples of 98 and 99% pure resveratrol from different vendors were of sufficiently small particle size. Only the Vital Prime sample was problematic in that regard. I think mixing your own from a reliable vendor's product is less expensive than the capsules will prove to be.
Posted 09 October 2008 - 12:42 PM
Where/how can we get this?
Several of us have been "mixing our own" for over a year now, as per the recipes in the Maximizing Resveratrol Effectiveness thread. Milk, milk protein, HPMC or Lecithin and other recipes seem to be effective. My favorite is mixing reveratrol powder into a whey protein drink. Several samples of 98 and 99% pure resveratrol from different vendors were of sufficiently small particle size. Only the Vital Prime sample was problematic in that regard. I think mixing your own from a reliable vendor's product is less expensive than the capsules will prove to be.
Every time I want to make a jump, I see a post about joint problem or tendonitis. Is this really a problem with Resveratrol?
Posted 09 October 2008 - 04:53 PM
Posted 09 October 2008 - 10:11 PM
Edited by Matt, 09 October 2008 - 10:47 PM.
Posted 10 October 2008 - 10:54 AM
There is enough anecdotal evidence that I think it might be a problem for some people. We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis, so for these people resveratrol might not be a good idea. The reports of joint and tendon problems could indicate a metabolic quirk involving Sirt1.
Knowing what I know now, if I had never taken resveratrol but wanted to start, I would start with a dose of about 250 mg, for several days. If there were no ill effect, I would double the dose. I would continue doubling until I either noticed ill effects, or was satisfied with the amount I was taking. I think about 2.5 gm was the minimal amount Sirtris and Dr. Sinclair thought was likely to have a positive effect for their clinical trials on MELAS and diabetes.
If I began to experience inexplicable tendon or joint pain I thought was due to resveratrol, I would stop taking it. This is speculative, but there is some evidence behind it: I would immediately start to take quercetin, which blocks Sirt1, and so would perhaps reverse the problem. Quercetin is also supposed to help with joint problems like arthritis (as is resveratrol). I found Quercetin aggravated arthritic joint pain for me, where resveratrol relieves it. It was bad enough to override the pain relieving effects of resveratrol when taking both at once. Someone with a different metabolism might have the opposite reaction. Again, this is speculation, but I think it is possible that those with joint and tendon problems from resveratrol would benefit from quercetin.
In short, you will be performing an experiment without a control group, should you decide to take resveratrol. I suggest taking 98% or higher purity and carefully monitoring your reaction.
FWIW, I got "tennis elbow", a form of tendinitis, last summer after clearing brush on my "ranch." I was told it would take 6 months or more to heal. A friend who had had tennis elbow said it took her a year to regain full use of her arm without pain. For me, while taking 2 to 3 grams of resveratrol daily, the pain was mostly gone after a couple of weeks, and two months later it seems to have healed.
Posted 10 October 2008 - 11:07 AM
There is enough anecdotal evidence that I think it might be a problem for some people. We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis, so for these people resveratrol might not be a good idea. The reports of joint and tendon problems could indicate a metabolic quirk involving Sirt1.
Knowing what I know now, if I had never taken resveratrol but wanted to start, I would start with a dose of about 250 mg, for several days. If there were no ill effect, I would double the dose. I would continue doubling until I either noticed ill effects, or was satisfied with the amount I was taking. I think about 2.5 gm was the minimal amount Sirtris and Dr. Sinclair thought was likely to have a positive effect for their clinical trials on MELAS and diabetes.
If I began to experience inexplicable tendon or joint pain I thought was due to resveratrol, I would stop taking it. This is speculative, but there is some evidence behind it: I would immediately start to take quercetin, which blocks Sirt1, and so would perhaps reverse the problem. Quercetin is also supposed to help with joint problems like arthritis (as is resveratrol). I found Quercetin aggravated arthritic joint pain for me, where resveratrol relieves it. It was bad enough to override the pain relieving effects of resveratrol when taking both at once. Someone with a different metabolism might have the opposite reaction. Again, this is speculation, but I think it is possible that those with joint and tendon problems from resveratrol would benefit from quercetin.
In short, you will be performing an experiment without a control group, should you decide to take resveratrol. I suggest taking 98% or higher purity and carefully monitoring your reaction.
FWIW, I got "tennis elbow", a form of tendinitis, last summer after clearing brush on my "ranch." I was told it would take 6 months or more to heal. A friend who had had tennis elbow said it took her a year to regain full use of her arm without pain. For me, while taking 2 to 3 grams of resveratrol daily, the pain was mostly gone after a couple of weeks, and two months later it seems to have healed.
i never bothered to report joint pain after taking resv but i did notice 'clicking' issues in the knees, elbows and fingers when I moved such as standing up or reaching to get something etc when i decided to increase the resv dose.
while ive been taking resv since mid 2005 starting with longevinex, I decided to increase the dose earlier this year using 2x500mg of the pure revgenetics caps + 1x350mg of the relentless improvement cap + 1 x longevinex and the next day i had clicking joint issues which is the only way i can describe it. i immediately stopped taking resv and the joint issues disappeared. ive since run out of longevinex and relentless improvement and now take 500mg of revgenetics and no joint pain whatsoever. its all bit friggin weird...
Posted 29 November 2008 - 03:03 AM
Nice shot of the "RES 250 MG" Capsules!
I presume they are micronized, emulsified (or in cyclodextrin), and pure (99%) or better...
Nice
Anthony
Posted 29 November 2008 - 03:47 PM
Posted 30 November 2008 - 06:18 AM
I don't think resveratrol totally mimics the effects of CR. Gene expression profiling a while back showed (in some organism, I forget which) a similarity between CR and RSV, but the genes whose expressions changed only partially overlapped in the two cases.If activation of SIRT1 makes autoimmune response worse, then isn't this conflicting with the idea that resveratrol totally mimics the effects of calorie restriction? Because we know that CR is very effective at preventing, delay and even treating autoimmune diseases in rodents. I mean CR has worked in models of Lupus, MS, Sjogrens, among others.
I've wondered though whether CR by some sort of mechanism made me more likely to get tendinitis induced by quinolones. Which affected both achilles tendons and bilateral tendinitis in my wrists.
Posted 30 November 2008 - 01:08 PM
We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis,
Posted 30 November 2008 - 01:39 PM
I don't think resveratrol totally mimics the effects of CR. Gene expression profiling a while back showed (in some organism, I forget which) a similarity between CR and RSV, but the genes whose expressions changed only partially overlapped in the two cases.If activation of SIRT1 makes autoimmune response worse, then isn't this conflicting with the idea that resveratrol totally mimics the effects of calorie restriction? Because we know that CR is very effective at preventing, delay and even treating autoimmune diseases in rodents. I mean CR has worked in models of Lupus, MS, Sjogrens, among others.
I've wondered though whether CR by some sort of mechanism made me more likely to get tendinitis induced by quinolones. Which affected both achilles tendons and bilateral tendinitis in my wrists.
Posted 30 November 2008 - 01:48 PM
We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis,
Is this an anecdotal observation or a clinical one?
Edited by maxwatt, 30 November 2008 - 01:52 PM.
Posted 04 December 2008 - 10:14 AM
From Sunday's 60 Mins:
http://video.msn.com...:-1:ind:1:ff:8A
Posted 04 December 2008 - 10:46 AM
My favorite is mixing reveratrol powder into a whey protein drink.
Posted 04 December 2008 - 03:16 PM
My favorite is mixing reveratrol powder into a whey protein drink.
Can I ask why you are mixing your resveratrol into a whey protein drink? Is there somewhere else where this has been discussed?
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