19 replies to this topic

[bio123]

From Sunday's 60 Mins:

http://video.msn.com...:-1:ind:1:ff:8A

[Anthony_Loera]

Nice shot of the "RES 250 MG" Capsules!

I presume they are micronized, emulsified (or in cyclodextrin), and pure (99%) or better...

Nice
Anthony

Attached Files

•  Res250MG.Png   247.04KB   4 downloads
•  DavidInterview.Png   270.67KB   4 downloads

Edited by Anthony_Loera, 08 October 2008 - 04:02 PM.

[Forever21]

Where/how can we get this?

[maxwatt]

Where/how can we get this?

Several of us have been "mixing our own" for over a year now, as per the recipes in the Maximizing Resveratrol Effectiveness thread. Milk, milk protein, HPMC or Lecithin and other recipes seem to be effective. My favorite is mixing reveratrol powder into a whey protein drink. Several samples of 98 and 99% pure resveratrol from different vendors were of sufficiently small particle size. Only the Vital Prime sample was problematic in that regard. I think mixing your own from a reliable vendor's product is less expensive than the capsules will prove to be.

[bio123]

So is Dr Sinclair working on a new improved version of resveratrol then? He does say it won't
be available for about five years...

[Forever21]

Where/how can we get this?

Several of us have been "mixing our own" for over a year now, as per the recipes in the Maximizing Resveratrol Effectiveness thread. Milk, milk protein, HPMC or Lecithin and other recipes seem to be effective. My favorite is mixing reveratrol powder into a whey protein drink. Several samples of 98 and 99% pure resveratrol from different vendors were of sufficiently small particle size. Only the Vital Prime sample was problematic in that regard. I think mixing your own from a reliable vendor's product is less expensive than the capsules will prove to be.

Every time I want to make a jump, I see a post about joint problem or tendonitis. Is this really a problem with Resveratrol?

[maxwatt]

Where/how can we get this?

Several of us have been "mixing our own" for over a year now, as per the recipes in the Maximizing Resveratrol Effectiveness thread. Milk, milk protein, HPMC or Lecithin and other recipes seem to be effective. My favorite is mixing reveratrol powder into a whey protein drink. Several samples of 98 and 99% pure resveratrol from different vendors were of sufficiently small particle size. Only the Vital Prime sample was problematic in that regard. I think mixing your own from a reliable vendor's product is less expensive than the capsules will prove to be.

Every time I want to make a jump, I see a post about joint problem or tendonitis. Is this really a problem with Resveratrol?

There is enough anecdotal evidence that I think it might be a problem for some people. We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis, so for these people resveratrol might not be a good idea. The reports of joint and tendon problems could indicate a metabolic quirk involving Sirt1.

Knowing what I know now, if I had never taken resveratrol but wanted to start, I would start with a dose of about 250 mg, for several days. If there were no ill effect, I would double the dose. I would continue doubling until I either noticed ill effects, or was satisfied with the amount I was taking. I think about 2.5 gm was the minimal amount Sirtris and Dr. Sinclair thought was likely to have a positive effect for their clinical trials on MELAS and diabetes.

If I began to experience inexplicable tendon or joint pain I thought was due to resveratrol, I would stop taking it. This is speculative, but there is some evidence behind it: I would immediately start to take quercetin, which blocks Sirt1, and so would perhaps reverse the problem. Quercetin is also supposed to help with joint problems like arthritis (as is resveratrol). I found Quercetin aggravated arthritic joint pain for me, where resveratrol relieves it. It was bad enough to override the pain relieving effects of resveratrol when taking both at once. Someone with a different metabolism might have the opposite reaction. Again, this is speculation, but I think it is possible that those with joint and tendon problems from resveratrol would benefit from quercetin.

In short, you will be performing an experiment without a control group, should you decide to take resveratrol. I suggest taking 98% or higher purity and carefully monitoring your reaction.

FWIW, I got "tennis elbow", a form of tendinitis, last summer after clearing brush on my "ranch." I was told it would take 6 months or more to heal. A friend who had had tennis elbow said it took her a year to regain full use of her arm without pain. For me, while taking 2 to 3 grams of resveratrol daily, the pain was mostly gone after a couple of weeks, and two months later it seems to have healed.

[Forever21]

Thanks. I appreciate that.

For now, I think I'm going to stick with my Caloric Restriction.

[Matt]

If activation of SIRT1 makes autoimmune response worse, then isn't this conflicting with the idea that resveratrol totally mimics the effects of calorie restriction? Because we know that CR is very effective at preventing, delay and even treating autoimmune diseases in rodents. I mean CR has worked in models of Lupus, MS, Sjogrens, among others.

I've wondered though whether CR by some sort of mechanism made me more likely to get tendinitis induced by quinolones. Which affected both achilles tendons and bilateral tendinitis in my wrists.

Edited by Matt, 09 October 2008 - 10:47 PM.

[porthose]

There is enough anecdotal evidence that I think it might be a problem for some people. We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis, so for these people resveratrol might not be a good idea. The reports of joint and tendon problems could indicate a metabolic quirk involving Sirt1.

Knowing what I know now, if I had never taken resveratrol but wanted to start, I would start with a dose of about 250 mg, for several days. If there were no ill effect, I would double the dose. I would continue doubling until I either noticed ill effects, or was satisfied with the amount I was taking. I think about 2.5 gm was the minimal amount Sirtris and Dr. Sinclair thought was likely to have a positive effect for their clinical trials on MELAS and diabetes.

If I began to experience inexplicable tendon or joint pain I thought was due to resveratrol, I would stop taking it. This is speculative, but there is some evidence behind it: I would immediately start to take quercetin, which blocks Sirt1, and so would perhaps reverse the problem. Quercetin is also supposed to help with joint problems like arthritis (as is resveratrol). I found Quercetin aggravated arthritic joint pain for me, where resveratrol relieves it. It was bad enough to override the pain relieving effects of resveratrol when taking both at once. Someone with a different metabolism might have the opposite reaction. Again, this is speculation, but I think it is possible that those with joint and tendon problems from resveratrol would benefit from quercetin.

In short, you will be performing an experiment without a control group, should you decide to take resveratrol. I suggest taking 98% or higher purity and carefully monitoring your reaction.

FWIW, I got "tennis elbow", a form of tendinitis, last summer after clearing brush on my "ranch." I was told it would take 6 months or more to heal. A friend who had had tennis elbow said it took her a year to regain full use of her arm without pain. For me, while taking 2 to 3 grams of resveratrol daily, the pain was mostly gone after a couple of weeks, and two months later it seems to have healed.

i never bothered to report joint pain after taking resv but i did notice 'clicking' issues in the knees, elbows and fingers when I moved such as standing up or reaching to get something etc when i decided to increase the resv dose.

while ive been taking resv since mid 2005 starting with longevinex, I decided to increase the dose earlier this year using 2x500mg of the pure revgenetics caps + 1x350mg of the relentless improvement cap + 1 x longevinex and the next day i had clicking joint issues which is the only way i can describe it. i immediately stopped taking resv and the joint issues disappeared. ive since run out of longevinex and relentless improvement and now take 500mg of revgenetics and no joint pain whatsoever. its all bit friggin weird...

[maxwatt]

There is enough anecdotal evidence that I think it might be a problem for some people. We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis, so for these people resveratrol might not be a good idea. The reports of joint and tendon problems could indicate a metabolic quirk involving Sirt1.

Knowing what I know now, if I had never taken resveratrol but wanted to start, I would start with a dose of about 250 mg, for several days. If there were no ill effect, I would double the dose. I would continue doubling until I either noticed ill effects, or was satisfied with the amount I was taking. I think about 2.5 gm was the minimal amount Sirtris and Dr. Sinclair thought was likely to have a positive effect for their clinical trials on MELAS and diabetes.

If I began to experience inexplicable tendon or joint pain I thought was due to resveratrol, I would stop taking it. This is speculative, but there is some evidence behind it: I would immediately start to take quercetin, which blocks Sirt1, and so would perhaps reverse the problem. Quercetin is also supposed to help with joint problems like arthritis (as is resveratrol). I found Quercetin aggravated arthritic joint pain for me, where resveratrol relieves it. It was bad enough to override the pain relieving effects of resveratrol when taking both at once. Someone with a different metabolism might have the opposite reaction. Again, this is speculation, but I think it is possible that those with joint and tendon problems from resveratrol would benefit from quercetin.

In short, you will be performing an experiment without a control group, should you decide to take resveratrol. I suggest taking 98% or higher purity and carefully monitoring your reaction.

FWIW, I got "tennis elbow", a form of tendinitis, last summer after clearing brush on my "ranch." I was told it would take 6 months or more to heal. A friend who had had tennis elbow said it took her a year to regain full use of her arm without pain. For me, while taking 2 to 3 grams of resveratrol daily, the pain was mostly gone after a couple of weeks, and two months later it seems to have healed.

i never bothered to report joint pain after taking resv but i did notice 'clicking' issues in the knees, elbows and fingers when I moved such as standing up or reaching to get something etc when i decided to increase the resv dose.

while ive been taking resv since mid 2005 starting with longevinex, I decided to increase the dose earlier this year using 2x500mg of the pure revgenetics caps + 1x350mg of the relentless improvement cap + 1 x longevinex and the next day i had clicking joint issues which is the only way i can describe it. i immediately stopped taking resv and the joint issues disappeared. ive since run out of longevinex and relentless improvement and now take 500mg of revgenetics and no joint pain whatsoever. its all bit friggin weird...

could be the quercetinor other substances in longevinex combined with higher dose of resveratrol.

[piranha]

Nice shot of the "RES 250 MG" Capsules!

I presume they are micronized, emulsified (or in cyclodextrin), and pure (99%) or better...

Nice
Anthony

 resv250.gif   26.22KB   9 downloads

Another shot of the bottle. I would like to know the manufacture also.

[Anthony_Loera]

It certainly appears like they are ready to market it.

It appears to have a complete label, not like the simple label on the SRT501 bottle that Max showed us a while back.

A

[niner]

If activation of SIRT1 makes autoimmune response worse, then isn't this conflicting with the idea that resveratrol totally mimics the effects of calorie restriction? Because we know that CR is very effective at preventing, delay and even treating autoimmune diseases in rodents. I mean CR has worked in models of Lupus, MS, Sjogrens, among others.

I've wondered though whether CR by some sort of mechanism made me more likely to get tendinitis induced by quinolones. Which affected both achilles tendons and bilateral tendinitis in my wrists.

I don't think resveratrol totally mimics the effects of CR. Gene expression profiling a while back showed (in some organism, I forget which) a similarity between CR and RSV, but the genes whose expressions changed only partially overlapped in the two cases.

[Ethan]

We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis,

Is this an anecdotal observation or a clinical one?

[maxwatt]

If activation of SIRT1 makes autoimmune response worse, then isn't this conflicting with the idea that resveratrol totally mimics the effects of calorie restriction? Because we know that CR is very effective at preventing, delay and even treating autoimmune diseases in rodents. I mean CR has worked in models of Lupus, MS, Sjogrens, among others.

I've wondered though whether CR by some sort of mechanism made me more likely to get tendinitis induced by quinolones. Which affected both achilles tendons and bilateral tendinitis in my wrists.

I don't think resveratrol totally mimics the effects of CR. Gene expression profiling a while back showed (in some organism, I forget which) a similarity between CR and RSV, but the genes whose expressions changed only partially overlapped in the two cases.

It was covered in this topic: A Low Dose of Dietary Resveratrol Partially Mimics the Effects of CR

http://www.plosone.o...al.pone.0002264

"We note that unlike CR, resveratrol did not reduce circulating IGF-1 levels (Figure 2B), and there was also no decrease in spontaneous tumors at the time of sacrifice (Supplemental Table S2). In particular, spontaneous liver tumors were abundant in mice fed the control diet or resveratrol, but rare in CR mice. Thus, although a low dose of resveratrol can improve quality of life by retarding aging parameters such as cardiac dysfunction, a nutritional or pharmaceutical strategy to also increase lifespan in mice will likely require blockage of the IGF-1 axis or its targets."

Folic acid reduces circulating IGF-1. It could be added to one's regimen, but don't overdo it. See above topic.

[maxwatt]

We know that Sirt1 can aggravate autoimmune diseases such as rheumatoid arthritis,

Is this an anecdotal observation or a clinical one?

See this topic Resveratrol and autoimmune conditions
and Sirtuins in Aging and Age-Related Disease...

Resveratrol activates things that contribute to certain auto-immune conditions, and we have some anecdotal reports of worsened conditions, but no one has established a direct causal relationship. It is possible that some auto-immune conditions are helped by resveratrol.

Edited by maxwatt, 30 November 2008 - 01:52 PM.

[Ben]

From Sunday's 60 Mins:

http://video.msn.com...:-1:ind:1:ff:8A

I love how they're talking about visible aging whilst basking in the high-UV of the Australian sun.

[Ben]

My favorite is mixing reveratrol powder into a whey protein drink.

Can I ask why you are mixing your resveratrol into a whey protein drink? Is there somewhere else where this has been discussed?

[maxwatt]

My favorite is mixing reveratrol powder into a whey protein drink.

Can I ask why you are mixing your resveratrol into a whey protein drink? Is there somewhere else where this has been discussed?

Milk proteins bind weakly to resveratrol, so it dissolves. It is released in the intestines as the protein is digested, effectively micronized, we think. This was discussed last spring in the topic on how to maximize resveratrol effectiveness.

Tea is another means of dissolving resveratrol in a liquid. I like it just as well, though the solubility is not as great as with whey protein.