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GM Antioxidants


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#1 Lazarus Long

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Posted 28 October 2008 - 03:12 AM


This is one that crosses so many categories that I decided to put it here in genetics. Scientists have been able to modify tomatoes to produce large quantities of antioxidants, anthocyanins in particular. Attack of the *life saving* purple tomatoes. I want some for my salad and I wonder how many more such breakthroughs are coming.

In this case the tomatoes have already been effective at extending the lives of mice that were bred to die from cancer by preventing the onset of the disease. I would love to see more vegetables modified in this manner to include other antioxidants like resveratrol. It seems to me that both for making production less costly AND for making inclusion in our diet easier this is the better way to go, rather than just relying on additional supplements.

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Scientists develop cancer fighting tomato

By Michael Kahn Michael Kahn – Sun Oct 26, 6:50 pm ET

LONDON (Reuters) – A purple tomato genetically engineered to contain nutrients more commonly seen in dark berries helped prevent cancer in mice, British researchers said on Sunday. The finding, published in the journal Nature Biotechnology, bolsters the idea that plants can be genetically modified to make people healthier.

Cancer-prone mice fed the modified fruit lived significantly longer than animals fed a standard diet with and without regular tomatoes, Cathie Martin and colleagues at the government-funded John Innes Center in Britain reported.

"The effect was much bigger than we had expected," said Martin, a plant biologist.

The study focused on anthocyanins, a type of antioxidant found in berries such as blackberries and blackcurrants that have been shown to lower risk of cancer, heart disease and some neurological diseases.

While an easy health boost, many people do not eat enough of these fruits, the researchers said.

Using genes that help color the snapdragon flower, the researchers discovered they could get the tomatoes to make anthocyanins -- turning the tomato purple in the process.

Mice genetically engineered to develop cancer lived an average of 182 days when they were fed the purple tomatoes, compared to 142 days for animals on the standard diet.

"It is enormously encouraging to believe that by changing diet, or specific components in the diet, you can improve health in animals and possibly humans," Martin said in a telephone interview.

The researchers cautioned that trials in humans are a long way off and the next step is to investigate how the antioxidants actually affect the tumors to promote better health. But the findings do bolster research suggesting that people can significantly improve their health by making simple changes to the daily diet, other researchers said.

"It's exciting to see new techniques that could potentially make healthy foods even better for us," said Dr. Lara Bennett, science information officer at Cancer Research UK.

"But it's too early to say whether anthocyanins obtained through diet could help to reduce the risk of cancer."

(Reporting by Michael Kahn; Editing by Maggie Fox and )

#2 Lazarus Long

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Posted 28 October 2008 - 02:32 PM

After a review of recent posts I noticed that Lucid had actually beat me to the punch with this topic but since we put them in different but equally relevant areas of discussion so I am going to leave this one and reference his topic for the great links he provided.

I really hope we see a lot more of this kind of research and have it move into other food types like mushrooms and even fermented foods where it might be easier to insert specific genes for increasing the nutrient and supplement value of the end product.

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