11 replies to this topic

[Anthony_Loera]

Hi guys,

We have a new cream that will be on our website soon. We called it Sirtuin Skin, and need a bit of input in case you would like to see something else added in our next formulation. This will only be at our site for a limited time later this month.

=========================================================
Here are the ingredients:
=========================================================

4 Ingredients: That initially make skin feel and smell rejuvenated:
=========================================================
Delonized Water(Aqua):
This is simply high quality pure water.

Cetearyl Alcohol:
This gives skin a velvety feeling. Basically it is an emulsifying wax produced from a mixture of fatty alcohols. It is made from cetyl and stearyl alcohol's. These form an occlusive film to keep skin moisture from evaporating.

Glyceryl Stearate and PEG 100 Stearate:
PEG 100 Stearate simply has a softening effect on the skin while Glyceryl Stearate serves as an emulsifier.

Citrus Aurantium Dulcis (Orange) Fragrance:
Primarily used as fragrance, and is suitable for sensitive skin.


4 Ingredients: That actually help rejuvenate the skin over time:
=========================================================
Acetyl Hexapeptide-3:
This peptide has been shown to reduce wrinkle depth, specially around the forehead and eyes. This was shown in a study published in the International Journal of Cosmetic Science in 2002. In the study, it was demonstrated that a cream containing 10% acetyl hexapeptide-3 used by healthy women volunteers reduced wrinkle depth up to 30 percent after 30 days of treatment.

In another study, an open label-trial of 5% acetylhexapeptide-3 cream applied twice daily on 10 women demonstrated a 27% improvement in periorbital rhytids after 30 days as measured by silicone replica analysis (25). Theoretically, this peptide may mimic the effects of botulinum toxin injections.[1]

[1]Centerchem: Argireline®. http://www.centerche...ine w stamp.pdf, Barcelona, Spain, accessed 2006.

PALMITOYL PENTAPEPTIDE-4 (Matrixyl):
This peptide restores the dermal matrix by the development of new collagen, elastin, and glycosaminoglycans in the dermal layer of the skin.

In a 12-week double-blind, placebo-controlled, split-face, left-right randomized clinical study of 93 Caucasian women aged 35–55, PALMITOYL PENTAPEPTIDE-4 provided significant improvement versus placebo control for reduction in wrinkles/fine lines by both qualitative technical and expert grader image analysis[2].

[2] Lintner K. Promoting production in the extracellular matrix without compromising barrier. Cutis 2002: 70 (6 Suppl.): 13–16.

Sodium Hyaluronate or HA:
Sodium hyaluronate is a key for maintaining water substances in human skin. Normally over time because of aging, natural HA can be decreased in the skin. The skins ability to maintain moisture is weakened, and gives the appearance of being dry and rough. When HA is applied back to the skin, it penetrates the dermis, combines with water, and promotes micro circulation and nutrient absorption. It forms an air permeable layer, to keep the skin moist and smooth.

Resveratrol:
Resveratrol is one of the strongest Sirtuin activators available. While most folks do not know what Sirtuins do, we will instead first compare it to with a substance called Idebenone used in skin care products. Idebenone is a close relative to the compound Co-Enzyme Q10. Idebenone is found in some of the best skin care products, and has been found to be popular product because it has a higher oxidative stress protection capacity than Co-Enzyme Q10.

Recently Resveratrol has been shown to have 17 times greater antioxidant activity, than idebenone[3]. While older studies suggest resveratrol may have some serious environmental protection capabilities that idebenone does not have and that these appear to work from within cells.

It is known that Sirtuins control genes indirectly in the cell nucleus. This maybe responsible for the environmental protection benefits and antioxidant activity as well as other benefits that other ingredients simply cannot match.

Normally resveatrol is not very soluble and may not pass through the skin easily, however we believe that using RevGenetics micronized resveratrol particles in combination with the proven peptides mentioned above and Sodium hyaluronate (also known as HA) can serve as a unique carrier for the micronized particles that are smaller than red blood cells. This can provide skin cells with the resveratrol required to activate the beneficial Sirtuin effects in the skin. Providing radient skin for a long time to come.

[3] Baxter, R (2008) Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation. Journal of Cosmetic Dermatology. 7 (1) p2-7.


4 Ingredients: That preserve and protect your cream:
=========================================================

Phenoxyethanol:
This is a common cosmetic preservative. It is considered one of the less irritating ones to use in most cosmetics. The following product types currently use this preservative: facial moisturizer/treatments, anti-aging, sunscreen spf 15 and above, moisturizers, mascaras, facial cleansers, other products with spf, foundations, body wash/cleansers, and exfoliant/scrubs.

Caprylyl Glycol:
This is derived from coconut. It is used as moisturizing or wetting agent that has antimicrobial properties and is used in conjunction with other ingredients as a preservative.

Stearic acid:
Derived from vegetable soybeans, it is used to add firmness to the Sirtuin Skin cream.

Potassium Sorbate:
This is used to inhibit molds, yeasts, and fungi. Potassium sorbate is non-irritating and non-sensitizing.

Attached Files

•  SirtuinSkin_50ml_2T.jpg   9.94KB   7 downloads

Edited by Anthony_Loera, 03 November 2008 - 10:27 PM.

[Eva Victoria]

Hi guys,

We have a new cream that will be on our website soon. We called it Sirtuin Skin, and need a bit of input in case you would like to see something else added in our next formulation. This will only be at our site for a limited time later this month.

=========================================================
Here are the ingredients:
=========================================================

4 Ingredients: That initially make skin feel and smell rejuvenated:
=========================================================
Delonized Water(Aqua):
This is simply high quality pure water.

Cetearyl Alcohol:
This gives skin a velvety feeling. Basically it is an emulsifying wax produced from a mixture of fatty alcohols. It is made from cetyl and stearyl alcohol's. These form an occlusive film to keep skin moisture from evaporating.

Glyceryl Stearate and PEG 100 Stearate:
PEG 100 Stearate simply has a softening effect on the skin while Glyceryl Stearate serves as an emulsifier.

Citrus Aurantium Dulcis (Orange) Fragrance:
Primarily used as fragrance, and is suitable for sensitive skin.


4 Ingredients: That actually help rejuvenate the skin over time:
=========================================================
Acetyl Hexapeptide-3:
This peptide has been shown to reduce wrinkle depth, specially around the forehead and eyes. This was shown in a study published in the International Journal of Cosmetic Science in 2002. In the study, it was demonstrated that a cream containing 10% acetyl hexapeptide-3 used by healthy women volunteers reduced wrinkle depth up to 30 percent after 30 days of treatment.

In another study, an open label-trial of 5% acetylhexapeptide-3 cream applied twice daily on 10 women demonstrated a 27% improvement in periorbital rhytids after 30 days as measured by silicone replica analysis (25). Theoretically, this peptide may mimic the effects of botulinum toxin injections.[1]

[1]Centerchem: Argireline®. http://www.centerche...ine w stamp.pdf, Barcelona, Spain, accessed 2006.

PALMITOYL PENTAPEPTIDE-4 (Matrixyl):
This peptide restores the dermal matrix by the development of new collagen, elastin, and glycosaminoglycans in the dermal layer of the skin.

In a 12-week double-blind, placebo-controlled, split-face, left-right randomized clinical study of 93 Caucasian women aged 35–55, PALMITOYL PENTAPEPTIDE-4 provided significant improvement versus placebo control for reduction in wrinkles/fine lines by both qualitative technical and expert grader image analysis[2].

[2] Lintner K. Promoting production in the extracellular matrix without compromising barrier. Cutis 2002: 70 (6 Suppl.): 13–16.

Sodium Hyaluronate or HA:
Sodium hyaluronate is a key for maintaining water substances in human skin. Normally over time because of aging, natural HA can be decreased in the skin. The skins ability to maintain moisture is weakened, and gives the appearance of being dry and rough. When HA is applied back to the skin, it penetrates the dermis, combines with water, and promotes micro circulation and nutrient absorption. It forms an air permeable layer, to keep the skin moist and smooth.

Resveratrol:
Resveratrol is one of the strongest Sirtuin activators available. While most folks do not know what Sirtuins do, we will instead first compare it to with a substance called Idebenone used in skin care products. Idebenone is a close relative to the compound Co-Enzyme Q10. Idebenone is found in some of the best skin care products, and has been found to be popular product because it has a higher oxidative stress protection capacity than Co-Enzyme Q10.

Recently Resveratrol has been shown to have 17 times greater antioxidant activity, than idebenone[3]. While older studies suggest resveratrol may have some serious environmental protection capabilities that idebenone does not have and that these appear to work from within cells.

It is known that Sirtuins control genes indirectly in the cell nucleus. This maybe responsible for the environmental protection benefits and antioxidant activity as well as other benefits that other ingredients simply cannot match.

Normally resveatrol is not very soluble and may not pass through the skin easily, however we believe that using RevGenetics micronized resveratrol particles in combination with the proven peptides mentioned above and Sodium hyaluronate (also known as HA) can serve as a unique carrier for the micronized particles that are smaller than red blood cells. This can provide skin cells with the resveratrol required to activate the beneficial Sirtuin effects in the skin. Providing radient skin for a long time to come.

[3] Baxter, R (2008) Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation. Journal of Cosmetic Dermatology. 7 (1) p2-7.


4 Ingredients: That preserve and protect your cream:
=========================================================

Phenoxyethanol:
This is a common cosmetic preservative. It is considered one of the less irritating ones to use in most cosmetics. The following product types currently use this preservative: facial moisturizer/treatments, anti-aging, sunscreen spf 15 and above, moisturizers, mascaras, facial cleansers, other products with spf, foundations, body wash/cleansers, and exfoliant/scrubs.

Caprylyl Glycol:
This is derived from coconut. It is used as moisturizing or wetting agent that has antimicrobial properties and is used in conjunction with other ingredients as a preservative.

Stearic acid:
Derived from vegetable soybeans, it is used to add firmness to the Sirtuin Skin cream.

Potassium Sorbate:
This is used to inhibit molds, yeasts, and fungi. Potassium sorbate is non-irritating and non-sensitizing.

Propylene Glycol would not harm to add for better delivery of the actives into deeper layers of the Epidermis.
Maybe Vit. C+E could add additional anti-oxidant protection? (It is always better to relay on several anti-oxidants than only one).
And I would definitely count on a chalating-antioxidant (complex) to make this creme a state of the art up-to-date moisturizer.

Maybe making it in two formulation would be a good idea as well. One for oily/combo and one for dry/very dry skin. In the latter one could add Glycerin to enhance its moisturizing effect.

[Anthony_Loera]

Propylene Glycol would not harm to add for better delivery of the actives into deeper layers of the Epidermis.
Maybe Vit. C+E could add additional anti-oxidant protection? (It is always better to relay on several anti-oxidants than only one).
And I would definitely count on a chalating-antioxidant (complex) to make this creme a state of the art up-to-date moisturizer.

Maybe making it in two formulation would be a good idea as well. One for oily/combo and one for dry/very dry skin. In the latter one could add Glycerin to enhance its moisturizing effect.

Hi Eva,

thanks for the feedback, I believe your idea about splitting it into 2 formulations is really a terrific idea. I will definitely consider that as well as maybe adding a couple more anti-oxidants. Maybe even a third peptide.

thanks again Eva, your input here on this board... (as always) is invaluable...

A

[Eva Victoria]

Propylene Glycol would not harm to add for better delivery of the actives into deeper layers of the Epidermis.
Maybe Vit. C+E could add additional anti-oxidant protection? (It is always better to relay on several anti-oxidants than only one).
And I would definitely count on a chalating-antioxidant (complex) to make this creme a state of the art up-to-date moisturizer.

Maybe making it in two formulation would be a good idea as well. One for oily/combo and one for dry/very dry skin. In the latter one could add Glycerin to enhance its moisturizing effect.

Hi Eva,

thanks for the feedback, I believe your idea about splitting it into 2 formulations is really a terrific idea. I will definitely consider that as well as maybe adding a couple more anti-oxidants. Maybe even a third peptide.

thanks again Eva, your input here on this board... (as always) is invaluable...

A

Thank you, Anthony! Am glad I could be of help

[sthira]

Eva, what's your opinion of this product? Do you think it's worth the purchase?

[Eva Victoria]

Eva, what's your opinion of this product? Do you think it's worth the purchase?

To be able to answer this question I would have to see the full ingredients list.

[Brafarality]

Propylene Glycol would not harm to add for better delivery of the actives into deeper layers of the Epidermis.
Maybe Vit. C+E could add additional anti-oxidant protection? (It is always better to relay on several anti-oxidants than only one).
And I would definitely count on a chalating-antioxidant (complex) to make this creme a state of the art up-to-date moisturizer.

Maybe making it in two formulation would be a good idea as well. One for oily/combo and one for dry/very dry skin. In the latter one could add Glycerin to enhance its moisturizing effect.

Hi Eva,

thanks for the feedback, I believe your idea about splitting it into 2 formulations is really a terrific idea. I will definitely consider that as well as maybe adding a couple more anti-oxidants. Maybe even a third peptide.

thanks again Eva, your input here on this board... (as always) is invaluable...

A

Thank you, Anthony! Am glad I could be of help

The way you openly and selflessly share your knowledge is truly indicative of an enlightened mind.
I hope, though, you keep a few trade secrets for yourself- just a few- that you will infuse into your product line to make it stand out that much more- give it that edge.

Cheers.

[porthose]

Anthony, thanks for producing this.

i sent you an email a couple of days ago in relation to adding extra ingredients to the new formulation but perhaps i should have posted here first...

anyway, i'm using another skin cream which is terrific and i've been adding the following ingredients from the SkinActives site. The ingredients simply make a great product (Juvess) even better.

Antioxident Booster
Hyaluronic Acid Powder
Sea Kelp Bioferment
ELS Serum

There was a discussion about adding extra ingredients to already formulated products which prompted me to go along with this but I can't find the thread in question. Obviously when adding extra ingredients, you have the potential to change the existing consistency of the skin cream either making it thicker and therefore difficult to moisturise with or making the cream a lot thinner and runnier. So what i've been doing is adding the ingredients slowly one at a time and mixing thoroughly before adding the next. The consistency of the cream is more or less the same.

My question therefore is: could I add these ingredients to the Anthony's new formulation to make a 'top product' even better ? Personally, I don't see why not but someone FAR more knowledgeable than me could answer this.

[Eva Victoria]

Propylene Glycol would not harm to add for better delivery of the actives into deeper layers of the Epidermis.
Maybe Vit. C+E could add additional anti-oxidant protection? (It is always better to relay on several anti-oxidants than only one).
And I would definitely count on a chalating-antioxidant (complex) to make this creme a state of the art up-to-date moisturizer.

Maybe making it in two formulation would be a good idea as well. One for oily/combo and one for dry/very dry skin. In the latter one could add Glycerin to enhance its moisturizing effect.

Hi Eva,

thanks for the feedback, I believe your idea about splitting it into 2 formulations is really a terrific idea. I will definitely consider that as well as maybe adding a couple more anti-oxidants. Maybe even a third peptide.

thanks again Eva, your input here on this board... (as always) is invaluable...

A

Thank you, Anthony! Am glad I could be of help

The way you openly and selflessly share your knowledge is truly indicative of an enlightened mind.
I hope, though, you keep a few trade secrets for yourself- just a few- that you will infuse into your product line to make it stand out that much more- give it that edge.

Cheers.

Thank you, Paul for your kind words!
Believe me even if I told you all my trade-secrets it would be very difficult to achieve the same product. It is not only about knowledge but also about experience.
I personally think that it is important to help others who want to formulate their own products to be able to achieve the best possible quality and give the best results to consumers as well.

[Eva Victoria]

Anthony, thanks for producing this.

i sent you an email a couple of days ago in relation to adding extra ingredients to the new formulation but perhaps i should have posted here first...

anyway, i'm using another skin cream which is terrific and i've been adding the following ingredients from the SkinActives site. The ingredients simply make a great product (Juvess) even better.

Antioxident Booster
Hyaluronic Acid Powder
Sea Kelp Bioferment
ELS Serum

There was a discussion about adding extra ingredients to already formulated products which prompted me to go along with this but I can't find the thread in question. Obviously when adding extra ingredients, you have the potential to change the existing consistency of the skin cream either making it thicker and therefore difficult to moisturise with or making the cream a lot thinner and runnier. So what i've been doing is adding the ingredients slowly one at a time and mixing thoroughly before adding the next. The consistency of the cream is more or less the same.

My question therefore is: could I add these ingredients to the Anthony's new formulation to make a 'top product' even better ? Personally, I don't see why not but someone FAR more knowledgeable than me could answer this.

Remember by adding extra ingredients to a product it'll dilute the concentration of the existing ones. And you should be aware of whether the ingredient you are adding is water or fat soluble. (Adding fat soluble ingredient to a moisturizer that is rich in water and the ingredient in question is not premixed from the producer can ruin your existing product. Due to "fat bubbles" / un-mixible molecules floating in your cream).

[HereInTheHole]

If you come up with a formulation for dry skin, I'll buy it. Only the most oily applications work for me. You might figure out something that works without the heavy, shiny coating.

[Mind]

Antioxident Booster

Wasn't there a recent report and accompanying Imminst discussion about how many antioxidants in skin creams are ineffective and possibly detrimental to skin appearance/health.