Gentlemen. Evaluate. Comment.
Plain Mega-Dose Resveratrol Fails To Mimic Metabolic Effects Of Calorie Restriction
Has The Idea Of A Red-Wine Resveratrol Pill, That Mimics A Calorie-Restricted Diet, Fizzled?
In a surprising mouse study conducted by researchers at Williams College (Williamstown, Mass), researchers report that resveratrol (rez-vair-ah-trawl), widely known as a red wine molecule and purported to be a molecular mimic of a restricted calorie diet, failed to produce the characteristic metabolic effects commonly observed in animals given a limited-calorie diet.
Animals placed on mega-dose resveratrol (4200-7070 mg equivalent for a 160-lb human) did not reduce body temperature or slow the heart rate, effects which are commonly observed among calorie-restricted animals.
Another less publicized study published last year also showed resveratrol did not slow heart rate. The heart rate in mice fed a standard-calorie diet was 342 beats per minute vs 360 beats per minute for resveratrol-fed mice. [Biology Trace Element Research 2007 118:250–254]
Furthermore, in striking opposition to a previous trial, Williams College researchers found mega-dose resveratrol actually reduced physical endurance in a mouse treadmill test.
The study, published in an advanced online edition of The FASEB Journal (Fellowship of Experimental Biology & Medicine, Dec, 4, 2008), follows a report issued in August of 2008 showing animals on a standard-calorie diet given mega-dose plain resveratrol (360-1565 milligrams) did not live as long as mice who were not given resveratrol. In fact, as the dose of resveratrol increased, lifespan decreased. [Cell Metabolism 2008 August; 8(2): 157–168]
The mice in this August 2008 study did exhibit profound improvements in health, including prevention of cataracts, reduced inflammation and greater motor nerve coordination. But the failure to prolong life was a setback to the idea of mega-dose resveratrol as an anti-aging pill. [Cell Metabolism 2008 August; 8(2): 157–168]
A growing body of data appears to be pointing towards lower-dose resveratrol and synergistic biological action when resveratrol is accompanied by an array of other natural molecules, similar in dosage to the amount of polyphenolic molecules provided in 3-to-5 glasses of dark red wine.
In June 2008 University of Wisconsin researchers reported relatively low dose resveratrol (a human equivalent dose of 343 mg) closely mimics the global gene activation profile of calorie restriction. [PLoS ONE 2008 3(6): e2264] Calorie restriction unequivocally prolongs the life of all life forms, approximately doubling the lifespan by cutting caloric intake in half.
Then in September of 2008 the same researchers reported that a patented array of nutriceuticals (Longevinex®), which included resveratrol, quercetin and rice bran phytate IP6, significantly affected 9-times more genes (1711 gene) than calorie restriction (198 genes) or plain resveratrol (225 genes) at a dose of resveratrol (100 mg resveratrol human equivalent) that was 17-320 times lower than prior studies. Longevinex® provides a total of 250 mg of mineral-chelating (key-lay-ting) molecules, about what is provided in 3-5 glasses of dark red wine. Red wine drinking populations in France and Sardinia are known to exhibit unusual longevity despite their high-calorie diets.
A plethora of mega-dose resveratrol dietary supplements came onto the market in 2006 following a study showing mega-dose resveratrol (1565 mg) did indeed increase the lifespan of mice. But the mice were engorged with a supra-high fat calorie diet (~60% fat calories) which is far greater than a typical human diet (~30% fat calories), so it is not applicable to the human condition. [Nature. 2006 Nov 16; 444 (7117):337-42] News reports at the time claimed only mega-dose resveratrol would be effective, based upon statements by an Ivy League university professor who was touting a resveratrol-based, gene activating drug at the time.
For more authoritative information about resveratrol and red wine pills, you are invited to visit www.longevinex.com #### Copyright 2008 Resveratrol Partners LLC Not for posting on other websites. .
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Abstract
FASEB Journal 2008 Dec 4. [Epub ahead of print]
Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction.
Mayers JR, Iliff BW, Swoap SJ.
*Department of Biology, Williams College, Williamstown, Massachusetts, USA.
Dietary supplementation with resveratrol may produce calorie restriction-like effects on metabolic and longevity endpoints in mice. In this study, we sought to determine whether resveratrol treatment elicited other hallmark changes associated with calorie restriction, namely bradycardia and decreased body temperature. We found that during short-term treatment, wild-type mice on a calorie-restricted diet experienced significant decreases in both heart rate and body temperature after only 1 day whereas those receiving resveratrol exhibited no such change after 1 wk. We also used ob/ob mice to study the effects of long-term treatment because previous studies had indicated the therapeutic value of resveratrol against the linked morbidities of obesity and diabetes. After 12 wk, resveratrol treatment had produced no changes in either heart rate or body temperature. Strikingly, and in contrast to previous findings, we found that resveratrol-treated mice had significantly reduced endurance in a treadmill test. Quantitative reverse transcriptase-polymerase chain reaction suggested that a proposed target of resveratrol, Sirt1, was activated in resveratrol-treated ob/ob mice. Thus, we conclude that the bradycardia and hypothermia associated with calorie restriction occur through mechanisms unaffected by the actions of resveratrol and that further studies are needed to examine the differential effects of resveratrol in a leptin-deficient background.-Mayers, J. R., Iliff, B. W., Swoap, S. J. Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction.
©Copyright 2008 Resveratrol Partners LLC Not for posting on other websites.