6 replies to this topic

[tomnook]

link here

As Paul also commented : "

Its nice to see another one come along. Hopefully, each of them (referring to Alagebrium Chloride) will

work on different types of AGEs so that taking several will effect the

breaking and elimination of all the most important types."

I've personally been taking a small amount of Alagebrium Chloride (Generic ALT-711) for the past year during which time I've seen my pulse pressure reduce significantly from approximately 60 to more like 40. Similarly, during this period my systolic reading has dropped from borderline high to 105-115 however I do also take a number of supplements which have probably also contributed to this fall.

There's a great deal of information concerning Alagebrium on Paul and Kitty's MoreLife site : follow the link to Paul or Kitty's regimens for anyone interested.

[pycnogenol]

"...I've personally been taking a small amount of
Alagebrium Chloride (Generic ALT-711) for the past year..."

How much is "a small amount" of this substance are you taking?

Edited by pycnogenol, 26 December 2008 - 10:44 PM.

[StrangeAeons]

Is there any data associating AGE's with essential hypertension? Otherwise I would have to imagine the BP drop would mediated by other properties of this stuff.

[niner]

Is there any data associating AGE's with essential hypertension? Otherwise I would have to imagine the BP drop would mediated by other properties of this stuff.

I think that Alteon's original application was hypertension. It had some interesting results in human trials, along with some complexity. There were funding problems, possibly due to reasons other than efficacy. I wonder if this could be one of those cases where it works in some people but not others? Like people who are mice, for example... I don't mean to be snide. It's awfully freaking hard to get a drug approved. The world is littered with unapproved drugs that actually work pretty well, like ViroPharma's cure for the common cold. ALT-711 showed some really promising results in diabetic nephropathy, too.

Edited by niner, 28 December 2008 - 05:40 AM.

[rwac]

Is there any data associating AGE's with essential hypertension? Otherwise I would have to imagine the BP drop would mediated by other properties of this stuff.

I think that Alteon's original application was hypertension. It didn't look so good in the human trials, so it kind of flamed out. I wonder if this could be one of those cases where it works in some people but not others? Like people who are mice, for example... I don't mean to be snide. It's awfully freaking hard to get a drug approved. The world is littered with unapproved drugs that actually work pretty well, like ViroPharma's cure for the common cold.

Why wouldn't a cure for the common cold be approved ?

[niner]

Why wouldn't a cure for the common cold be approved ?

A tox issue. Something like 3% of women using birth control developed abnormal bleeding when taking it. That was the biggest concern. It was seen as a drug that would be in widespread use, and therefore they wanted it to be squeaky clean.

[tomnook]

"...I've personally been taking a small amount of
Alagebrium Chloride (Generic ALT-711) for the past year..."

How much is "a small amount" of this substance are you taking?

I'm 54 years old and am presently taking 50mg BID - I've been doing so for the past three or four months. I started with 25mg BID a year ago and varied the dosage during this period whilst monitoring any possible effects on both my BP and pulse pressure. The present dosing appears to keep me maintaining the parameters which I set myself as a goal with my most recent readings being 112/70 pulse rate 71.

A relatively recent human trial in over 65's with isolated systoloic hypertension dosing 210mg BID had positive results here

Besides taking the alagebrium chloride I've made a number of other changes which may also have had a positive effect on my BP. A number of these changes thanks to comments made to me by Paul Wakfer a year or so ago (when my resting values were 144/78 72) - BMI reduced by 10% in the year, introduction of 3 x 25 mins of aerobic excercise and 3 x 25 mins of resistance excercise each week, reduction of high calorie, low nutrient dense carbs., similarly, a reduction of red meat consumption in favour of seafood (mainly fish oil caps!) and chicken and reduction of table salt, alcohol and caffeine intake. I also now supplement with L-Arginine 700mg BID , L-Arginine L-Citrulline complex 1000mg , Endothelial defense (good tip from Duke - thanks!) and Taurine 1000mg BID to keep me more relaxed. Also, a morning cup of hibiscus (roselle) tea one of many studies here .

A heart scan last month gave me a calcium score of zero which was the same as the previous seven years ago - my family has a history of cardiac issues, hence my interest in keeping mine in good shape.