7 replies to this topic

[M.speciosa]

I am going to be starting Nardil in a couple days. But I've been taking Adderall for the past two weeks now (today is my last dose). So my questions is: How long should I wait after cessation of the Adderall, to start taking the Nardil? If I remember correctly, the PI sheet says something like two weeks. But then again it also says that for Selegiline, and I've been taking very small doses of Adderall along with the Emsam for about a year with no negative side-effects.

Thanks for the help!

[k10]

I am going to be starting Nardil in a couple days. But I've been taking Adderall for the past two weeks now (today is my last dose). So my questions is: How long should I wait after cessation of the Adderall, to start taking the Nardil? If I remember correctly, the PI sheet says something like two weeks. But then again it also says that for Selegiline, and I've been taking very small doses of Adderall along with the Emsam for about a year with no negative side-effects.

Thanks for the help!

At least 1 week.

[M.speciosa]

Does anyone know if taking Adderall with Nardil is anymore dangerous than taking it with Selegiline?

[OneScrewLoose]

Nardil inhibits MAO A & B. Selegiline inhibits MAO B at lower doses and both MAO A and B at higher doses. Seriously would not recommend mixing

EDIT: I see you meant Adderal and Nardil, not Nardil and Selegiline. In that case, nvm.

Edited by OneScrewLoose, 28 December 2008 - 05:22 PM.

[bran319]

What are your doctors instructions?

Selegiline at the patch dosages will inhibit MAO-A so if you were taking adderall with it at these dosages and tolerated it well then you will likely not have a problem on another MAO-A inhibitor. Amphetamines and MAO-A inhibitors have been used in combination in clinical practice for years but it is a very tricky combo and should not be taken lightly. Defer to your doctor!

[yoyo]

well, you wouldn't have needed to wait a week. Just wait till its out of your system, which is just sleeping it off.

I would however be careful of a stimulant with a new MAOI, you can't assume it will have the same effect as a different MAOI you were on, so take a low dose of AMP to start.

[graatch]

Selegiline at the patch dosages will inhibit MAO-A so if you were taking adderall with it at these dosages and tolerated it well then you will likely not have a problem on another MAO-A inhibitor.

No it's not so sure. I feel you're expressing too little caution here.

Both selegiline and phenelzine have unique properties beyond MAOI (for one, some research suggests with selegiline an interaction with adrenergic receptors that may decrease-though-definitely-not-eliminate the risk of hypertensive reactions both from endogenous and exogenous direct/indirect adrenergic agonists -- hence I believe it is very possible for someone to be at risk of hypertensive reaction with phenelzine when a similar dose of exogenous substance gave them no problems on selegiline) and ... for all that we know, pharmacology is still tricky and strange things often happen, best to give unpleasant chemical death a wide berth.

Amphetamines and MAO-A inhibitors have been used in combination in clinical practice for years but it is a very tricky combo and should not be taken lightly. Defer to your doctor!

Yeah I agree! It can work for some people, with extreme care & the help of the doc. For some it can be marvelously effective in fact, a (yeah) lifesaving combination against some certain psychiatric symptom clusters. People forget that MAOIs and especially phenelzine are actually generally vasodilators unless you are having a hypertensive crisis (a rare thing, really, statistically), and in practice the drugs can sometimes help the side effects of each other. I mentioned in some other threads my acquaintance Chairman MAO who has been in remission from treatment-resistant depression, social phobia, and inattentive ADD with a combination of phenelzine (105mg daily) and dextroamphetamine (60mg daily divided into 4 doses), the d-amp being slowwwwwwly titrated up in intervals of 1.25mg with doctor's careful attention, and emergency anti-hypertensive medication always on hand. (The rescue medication in his case: Nifedipine, which he probably has switched to something else by now because nifedipine can tend to actually cause the opposite problem, dangerous hypotension, and lower the BP too quickly (can result in ischemia) anyway.)

well, you wouldn't have needed to wait a week. Just wait till its out of your system, which is just sleeping it off.

I would actually wait as long as possible to be sure, at least 2 ... 3 ... days; but yeah, the 2 weeks (once again I urge just-short-of-paranoiac dedication to caution in these matters) is needed after cessation of irreversible MAOI before taking a "sympathomimetic" or ingesting tyramine etc. (rather than vice versa as the OP's current situation) as monoamine oxidase actually needs to be recreated.

Mitragyna (OP): PM me on bluelight if you want, I still get a chance to check that inbox a lot ...

Edited by graatch, 13 January 2009 - 05:58 AM.

[StrangeAeons]

I suggest this thread be merged with this one as they are essentially discussing the same type of interaction, with a few twists; likewise suggest they both be moved to the underutilized Pharmacology subforum, as we are discussing medications, not supplements. Likewise I appear to have Nav-ambitions today .